CAS: 61-16-5; 2-Amino-1-(2,5-Dimethoxyphenyl)Propan-1-Ol,Hydrochloride
该化合物是一种合成化合物,主要在医疗环境中用作血管压抑剂,其特点是能够刺激甲型肾上腺受体,导致血管收缩和血压增加.该化合物看起来像白色和白外晶体粉,在水中溶解,适合静脉注射.盐酸甲胺的分子重量相对较低,在正常储存条件下保持稳定.其药理效应主要归因于对同情性...
- 英文名称2-Amino-1-(2,5-Dimethoxyphenyl)Propan-1-Ol,Hydrochloride
- 中文名称盐酸甲氧明
- IUPAC名称2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol;hydrochloride
- 其它别名Benzenemethanol,a-(1-aminoethyl)-2,5-dimethoxy-,hydr°Chloride (9CI); Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy-, hydr°Chloride (8CI); Methoxamine hydr°Chloride (6CI); 2-Amino-1-(2,5-dimethoxyphenyl)-1-propanolhydr°Chloride; 2-Amino-1-hydroxy-1-(2,5-dimethoxyphenyl)propane hydr°Chloride; Beta-hydroxy-beta-(2,5-dimethoxyphenol)-isopropylamine hydr°Chloride; Pressominhydr°Chloride; Vasoxine; Vasoxine hydr°Chloride; Vasoxyl; Vasoxylhydr°Chloride; Vasylox; a-(a-Aminoethyl)-2,5-dimethoxybenzylalcohol hydr°Chloride; b-Hydroxy-b-(2,5-dimethoxyphenyl)isopropylaminehydr°Chloride
- CAS编号61-16-5
- MFCD编号:MFCD00058607
- EINECS号:200-499-7
- FDA UNII编号:8MB4MJ9R7L
- 分子式:C11H18ClNO3
- 分子量:247.72
- 产品CID: 1593068
- 同类组份化合物CAS390-28-3 (free base)61-16-5 (HCl)
- 产品分类原料药 → 循环系统用药 → 抗休克血管活性药
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
2,5-二甲氧基苯丙酮置于盐酸,亚硝酸丁酯,Palladium 10% On Activated Carbon,氢气体系中,用 甲醇,乙醚,水 作为反应溶剂,化学反应生成 盐酸甲氧明
参考文献:一种赤式结构盐酸甲氧明的制备方法
标题:一种赤式结构盐酸甲氧明的制备方法
摘要:本发明公开了一种赤式结构盐酸甲氧明的制备方法,该方法包括以下步骤:(1)将初始原料2,5-二甲基苯丙酮溶于有机溶剂中,在通入干燥氯化氢气体的条件下,滴加亚硝酸正丁酯溶液进行肟化反应,得到中间体i;(2)在酸性条件下,以甲醇溶液作作为反应溶剂,以钯碳作为催化剂,采用氢气使中间体i中的肟基还原,得到中间体ii;(3)中间体ii进行氢化还原反应,得到赤式结构盐酸甲氧明.本发明方法的操作简单,经济环保,反应条件温和,同时产品质量非常好,产率高,能得到单独的赤式结构盐酸甲氧明.
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2906210000-苄醇
2922110001-单乙醇胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6030613-A
优先权日:1995-01-17
标题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; SIMISTER NEIL E; LENCER WAYNE I
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
专利号:CN-117247883-A
优先权日:2021-12-06
标题 :Application of L-phenylalanine mutase from Taxus chinensis in synthesis of beta-alanine
专利号:US-7547436-B2
优先权日:1995-01-17
标 题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; LENCER WAYNE I; SIMISTER NEIL E
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
专利号:CN-117070435-A
优先权日:2021-12-06
标 题:Use of L-glutamic acid-2, 3-aminomutase from Clostridioides difficile in synthesis of beta-alanine
专利号:CN-216538484-U
优先权日:2022-01-17
标 题 :A kind of preparation synthesis kettle of methoxyamine hydrochloride
专利号:CN-1238779-A
优先权日:1996-11-22
标题:Methods and compounds for inhibiting the release of beta-amyloid peptide and/or its synthesis
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主要参考文献
1: Bell D, Duffin A, Gruss HJ, Pediconi C, Jacobs A. A randomised, controlled, crossover study to investigate the pharmacodynamics, pharmacokinetics and safety of 1R,2S-methoxamine hydrochloride (NRL001) in healthy elderly subjects. Colorectal Dis. 2014 Mar;16 Suppl
1:27-35. doi: 10.1111/codi.12543. doi: 10.1111/codi.12541. English, French. J Am Med Assoc. 1958 Aug 9;167(15):1835-7. N Engl J Med. 1954 Apr 22;250(16):674-6.
合成参考文献
摘要:European Journal of Pharmacology., 9(289), 1970 []
摘要:Drug Dosages in Laboratory Animals - A Handbook, Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973, -(160), 1973
摘要:McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1128
摘要:Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 216
摘要:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2144
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