专利号:US-5098602-A 优先权日:1988-05-11 标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements 发明人:HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA 权利人:NIPPON MINING CO 摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k 专利号:US-2002058824-A1 优先权日:2000-11-15 标题:Solventless synthesis of hydrophilic phenol ester derivatives 发明人:MAJERCZAK VICTORIA ANN; GIBSON MICHAEL STEVEN; ORLANDO ROBERT JAMES 摘要:Process for preparing benzenesulfonate salts from an appropriately substituted acid chloride and a hydroxybenzenesulfonic acid is conducted in the absence of solvent, in a molar excess of acid chloride and in the presence of a phase transfer catalyst selected from quaternary ammonium and quaternary phosphonium salts and the target reaction product. The molar excess of the acid chloride is used to reduce the occurrence of gelation in the product.
专利号:US-10947189-B2 优先权日:2017-08-12 标 题:Online continuous flow process for the synthesis of organic peroxides using hydrogen peroxide as raw material 发明人:MA BING; PAN SHUAI; SHU XINLIN 权利人:SHANGHAI HYBRID CHEM TECH 摘要:An online continuous flow production process for directly preparing organic peroxides by using hydrogen peroxide as a raw material. This production process uses hydrogen peroxide, catalyst, and an oxidation substrate as a raw material. Substrate will be turned to designated peroxides sequentially through oxidation and workup. This process is performed in a plug-and-produce integrated continuous flow reactor, and the raw materials are continuously fed to the reactor. So, specified peroxide can be continuously obtained at the outlet of the plug-and-produce integrated continuous flow reactor.
专利号:US-2012172336-A2 优先权日:2009-03-19 标 题:Fosfluconazole Derivatives, Synthesis, and Use in Long Acting Formulations 发明人:GONNISSEN YVES; VOORSPOELS JODY 权利人:GONNISSEN YVES; VOORSPOELS JODY; SEPS PHARMA N V 摘要:The invention relates to a compound of formula (1) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R 1 to R 2 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.
专利号:US-2020172478-A1 优先权日:2017-08-12 标题 :Online continuous flow process for the synthesis of organic peroxides using hydrogen peroxide as raw material
专利号:WO-2010115869-A1 优先权日:2009-04-03 标 题 :Propofol phosphonyl derivatives, synthesis, and use in long acting formulations 发明人:GONNISSEN YVES RENE JOHANNA PAUL 权利人:SEPS PHARMA N V; GONNISSEN YVES RENE JOHANNA PAUL 摘要:This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH 2 ) P -O-, a single bond, formula (IA), -(CH 2 ) 1-8 -O-X(O)-, and - p is an integer from 1 to 8, - each R 3 and each R 4 is independently selected from the group consisting of C 1-20 alkyl, C 3-12 alkyl, C 3-12 cycloalkyl-C 1-4 alkyl, saturated heterocyclyl and saturated heterocyclyl-C 1-4 alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR 5 , - W is selected from the group consisting of halogen, OH, S(O)H and O - M + wherein M + is a monovalent cation; and - R 5 is selected from the group consisting of hydrogen and C 1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.
摘要:Koo, S., Science of Synthesis, (2010) 45, 1374. 摘要:Chciuk, T. V.; Flowers, R. A.; Flowers, R. A., Science of Synthesis Knowledge Updates, (2016) 2, 252. 摘要:Gosmini, C.; Corpet, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 710.