专利号:US-3852307-A 优先权日:1972-04-25 标 题 :Synthesis of zearalanone and related compounds 发明人:URRY W; MULLENBACH G 权利人:COMMERCIAL SOLVENTS CORP 摘要:WHEREIN X is an integer having a value from 0 to 6 inclusive and Y is an integer having a value from 3 to 8 inclusive. It also provides for new methods of making compounds useful in the synthesis of zearalanone and related compounds. The compounds 6-acetoxyhexanoic acid; 2-(5-hexenoyl)cyclohexanone; 7-keto-11-dodecenoic acid; 2-hydroxyethyl 7-keto11-dodecenoate ethylene ketal; N,N-dimethyl 7-keto-11dodecenamide ethylene ketal; 7-keto-11-dodecenal ethylene ketal; 9-keto-2,13-tetradecadienic acid ethylene ketal; 2-hydroxyethyl 9-keto-2,13-tetradecadienoate ethylene ketal; the sodium salt of ethyl 6-(6-keto-10-undecenyl)- Beta -dihydroresorcylate ethylene ketal; ethyl 3-bromo-6-(6-keto-10-undecenyl)- Beta dihydroresorcylate ethylene ketal; ethyl 6-(6-keto-10-undecenyl)Beta -resorcylate ehtylene ketal; ethyl 6-(6-keto-10-undecenyl)Beta -resorcylate ethylene ketal dibenzyl ether; ethyl 6-(6keto-10-hydroxyundecyl)- Beta -resorcylate ethylene ketal dibenzyl ether; and 6-(10-hydroxy-6-keto-undecyl)- Beta resorcylic acid dibenzyl ether are disclosed. Methods for preparing these compounds are also disclosed. This invention provides a new synthesis for zearalanone and for related compounds having more or fewer carbon atoms in the nonaromatic ring than does zearalanone, which related compounds and zearalanone are represented by the formula
专利号:US-2001044540-A1 优先权日:2000-03-23 标 题:Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors 发明人:PARSONS RODNEY L; DOROW ROBERTA L; DAVULCU AKIN H; FORTUNAK JOSEPH M; HARRIS GREGORY D; KAUFFMAN GOSS S; NUGENT WILLIAM A; RADESCA LILIAN A 摘要:This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.
专利号:US-6555686-B2 优先权日:2000-03-23 标题:Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors 发明人:PARSONS RODNEY L; DOROW ROBERTA L; DAVULCU AKIN H; FORTUNAK JOSEPH M; HARRIS GREGORY D; KAUFFMAN GOSS S; NUGENT WILLIAM A; RADESCA LILIAN A 权利人:BRISTOL MYERS SQUIBB PHARMA 摘要:This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.
专利号:US-11434217-B2 优先权日:2017-12-29 标 题 :Method for synthesis of lobaric acid and analog thereof 发明人:YIM JOUNG HAN; KIM IL-CHAN; HAN SE JONG; YOUN UI JOUNG; LEE HONG KUM; LEE JUN HYUCK; KIM TAI KYOUNG; YEO KWON JOO 权利人:KOREA INST OCEAN SCI & TECH; KOREA INSTITUTE OF OCEAN SCIENCE AND TECH 摘要:The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.
专利号:US-10981850-B2 优先权日:2019-04-15 标 题 :One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives 发明人:PORCO JOHN A; BEELER AARON B; BROWN LAUREN E; TRILLES RICHARD V 权利人:UNIV BOSTON 摘要:Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.
专利号:US-5386019-A 优先权日:1992-01-15 标 题 :Synthesis of inhibitors of calmodulin-mediated enzymes including KS-501, KS-502 and their enantiomers 发明人:DANISHEFSKY SAMUEL J; DUSHIN Russell; HAIT WILLIAM N 权利人:UNIV YALE 摘要:The total synthesis of a group of compounds with inhibitory effects on calmodulin-mediated enzyme activities has been accomplished. Among these synthesized compounds are KS-501 and KS-502. Other compounds that have been synthesized by the described scheme are ent-KS-501 and ent-KS-502 which are enantiomers of KS-501 and KS-502 and which also have inhibitory effects on calmodulin-mediated enzyme activities.
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合成参考文献
参考文献:10.1007/s00216-011-5206-x 摘要:Gadzała-Kopciuch R, Cendrowski K, Cesarz A, Kiełbasa P, Buszewski B. Determination of zearalenone and its metabolites in endometrial cancer by coupled separation techniques. Analytical and Bioanalytical Chemistry. 2011 Jul 13;401(7):2069. doi: 10.1007/s00216-011-5206-x.