CAS: 89786-04-9; (2S,3S,5R)-3-((1H-1,2,3-Triazol-1-yl)Methyl)-3-Methyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid 4,4-Dioxide

上下游产品

CAS号551-16-6 6-氨基青霉烷酸 | CAS号122661-93-2 benzhydryl-3-me... | CAS号85573-72-4 2-oxo-4-(benzot... | CAS号74189-25-6 diphenylmethyl ... | CAS号87579-78-0 (2S,5R)-3,3-二甲基... | CAS号80353-26-0 (2S,5R,6S)-二苯基甲... | CAS号59703-84-3 哌拉西林钠 | CAS号89785-84-2 他唑巴坦钠

Tazobactam Benzyl Ester置于palladium On Activated Charcoal,氢气体系中,用 乙醇 作为反应溶剂,化学反应 1.5H,以96.19%的收率获得产物他唑巴坦
参考文献:一种他唑巴坦的制备方法
标题:一种他唑巴坦的制备方法
摘要:本发明公开了一种他唑巴坦的制备方法.该方法以6α‑溴青霉烷‑3α‑羧酸‑1β‑氧化物为原料,先后经过酯化,还原,热裂解,氯甲基化,叠氮化,双氧化,环合加成和脱保护步骤得到他唑巴坦.该方法酯化反应中在碳酸氢钠存在下,采用溴化苄作为羧酸基团的保护基,然后用氢解反应来脱除苄基保护.其提供的羧基的保护和脱除方法与目前的工艺路线相比具有流程简单,环保,副产物低等优势.

专利信息

专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-11059835-B2
优先权日:2014-08-15
标 题 :Synthesis of cephalosporin compounds
发明人：WALLER DAVID; GAZDA GREGORY; MINDEN ZACHARY; BARTON LISA; LEIGH CLIFTON
权利人:MERCK SHARP & DOHME
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction.

专利号:US-11744867-B2
优先权日:2017-02-14
标 题 :Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease
发明人：NEEDHAM BRITTANY D; MAZMANIAN SARKIS K; SHARON GIL; FUNABASHI MASANORI; FISCHBACH MICHAEL A; HSIAO ELAINE Y; PATTERSON PAUL H
权利人:CALIFORNIA INST OF TECHN; UNIV CALIFORNIA
摘要:Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.

专利号:WO-2004075874-A1
优先权日:2003-02-28
标题 :Method for treatment and prevention of acute and chronic pseudomonas aeruginosa airway infections with inhalable macrolides
发明人：MENEKSE OKTAY
权利人:ANBICS PATENTS LICENCES AG; MENEKSE OKTAY
摘要:Macrolides, in particular azalides such as azithromycin, are suited for the treatment or prevention of acute or chronic P. aeruginosa infections of the airways by inhala­tion. The mechanism of action is the inhibition of the quo­rum sensing of P. aeruginosa, in particular the impediment of the las and rhl quorum sensing systems synthesis and the impediment of the synthesis of the autoinducers N-[3-oxodo­1o decanoyl]-L-homoserine lactone and N-butyrylhomoserine lac­tone. This allows for inhalation treatments of P. aerugi-nosa infections at non-inhibiting concentrations of the macrolide.

专利号:US-10941161-B2
优先权日:2014-08-15
标 题:Intermediates in the synthesis of cephalosporin compounds
发明人：MOSHOS KRISTOS ADRIAN; JURKAUSKAS VALDAS; FOGLIATO GIOVANNI; SCANU MANUEL; HWANG YOU SEOK
权利人:MERCK SHARP & DOHME
摘要:Described herein are crystalline forms of a compound of formula (III′), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.

专利号:US-11542279-B2
优先权日:2016-06-06
标 题:Solid forms of ceftolozane and processes for preparing
发明人：MALONEY KEVIN MATTHEW; SIROTA ERIC M; VARSOLONA RICHARD J; GAUTHIER JR DONALD R; REN HONG
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The instant invention is related to a novel solid form of ceftolozane sulfate (the DMAc solvate of ceftolozane sulfate (Form 3)), compositions comprising ceftolozane sulfate DMAc solvate (Form 3), synthesis of Form 3 and an improved crystallization process using Form 3 to prepare ceftolozane sulfate Form 2. Novel compositions also include ceftolozane sulfate solid Form 3 and/or other crystalline and amorphous solid forms of ceftolozane.