CAS: 99-24-1; Methyl 3,4,5-Trihydroxybenzoate

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CAS号67-56-1 甲醇 | CAS号149-91-7 没食子酸; 3,4,5-三羟基苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号66656-94-8 methyl 6-O-gall... | CAS号75-36-5 乙酰氯 | CAS号74-88-4 碘甲烷 | CAS号35388-10-4 3,4,5-trihydrox... | CAS号7647-01-0 盐酸 | CAS号7664-93-9 硫酸 | CAS号111394-44-6 (Z)-2-甲氧基-5-(2-... | CAS号3934-84-7 3,4-二羟基-5-甲氧基苯甲酸 | CAS号3934-86-9 3,4-二羟基-5-甲氧基苯甲酸甲酯 | CAS号41303-74-6 N-去甲基加兰它敏氢溴酸盐 | CAS号146300-69-8 7-hydroxy-2,2-d... | CAS号143259-87-4 methyl 3,4-dihy... | CAS号1486-47-1 3,4,5-tris(phen... | CAS号142531-43-9 methyl 7-phenyl... | CAS号477-90-7 岩白菜素 | CAS号188685-16-7 methyl 3,4,5-tr...

没食子酸置于氯化亚砜体系中,化学反应 2.5H,反应生成 没食子酸甲酯
参考文献:Synthesis Of Hyperbranched Glycodendrimers Incorporating α-Thiosialosides Based On A Gallic Acid Core
标题:Synthesis Of Hyperbranched Glycodendrimers Incorporating α-Thiosialosides Based On A Gallic Acid Core
摘要:含有唾液酸残基的超支化糖基树脂被合成,以进一步了解多价效应及其在碳水化合物-蛋白质相互作用中的作用.三价核心的没食子酸7和疏水性间隔物的寡乙二醇衍生物被用来支撑树状骨架.α-硫代唾液苷16通过亲核取代与n-氯乙酰化的树状前体13,14和26结合,形成三价17,18和九价27唾液树脂.完全糖去保护形成水溶性α-硫代唾液树脂21,22和29,这些树脂被用于蛋白结合研究.浑浊度分析证实了九价唾液树脂29具有九个易接近的唾液酸残基结合,交联和沉淀两种不同凝集素的强大潜力.初步结果表明,九价α-唾液树脂29对二聚麦芽凝集素(wga)和蛞蝓limaxflavus(lfa)的亲和力大于相应的三价糖基树脂21和22.关键词:碳水化合物,树脂,唾液酸,没食子酸,凝集素,麦芽凝集素,Limaxflavus.
DOI:10.1139/v97-177

专利信息

专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-7105695-B2
优先权日:2001-12-21
标题 :Synthesis of combretastatin A-2 prodrugs
发明人：PETTIT GEORGE R; MOSER BRYAN R
权利人:UNIV ARIZONA STATE
摘要:The original synthesis of combretastatin A-2 (1a) was modified to provide an efficient scale-up procedure for obtaining this antineoplastic stilbene. Subsequent conversion to a useful prodrug was accomplished by phosphorylation employing in situ formation of dibenzylchlorophosphite followed by cleavage of the benzyl ester protective groups with bromotrimethylsilane to afford phosphoric acid intermediate 11. The latter was immediately treated with sodium methoxide to complete a practical route to the disodium phosphate prodrug (2a). The phosphoric acid precursor (11) of phosphate 2a was employed in a parallel series of reactions to produce a selection of metal and ammonium cation prodrug candidates. Each of the phosphate salts (2a–q) was evaluated with respect to relative solubility behavior, cancer cell growth inhibition, and antimicrobial activity.

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:US-2025305010-A1
优先权日:2022-05-08
标题:Lipid compositions and methods of producing same
发明人：KEREN TOMER; ELLA EZRA; ARGOV-ARGAMAN NURIT
权利人:WILK TECH INTERNATIONAL LTD; YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:Provided is a method of increasing lipid synthesis or accumulation in mammary epithelial cells (MECs) culture and optionally secretion therefrom. The method comprising contacting the MECs with an LXR agonist in the presence of a fatty acid to thereby increase lipid synthesis or accumulation and optionally secretion of lipids. Also provided is a method of producing synthetic fat globules, the method comprising: (a) isolating lipid droplets from cells in culture; (b) encapsulating the droplets with a lipid bilayer, thereby producing synthetic fat globules. Also provided are compositions produced thereby.

专利号:US-8513395-B2
优先权日:2005-06-15
标题:Method for the synthesis of anthocyanins
发明人：BAKSTAD EINAR
权利人:BAKSTAD EINAR; BIOSYNTH AS
摘要:The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilize a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half intermediates that are then reacted with Western half intermediates to form the target anthocyanins. Some Eastern half intermediates and electrophilic precursors also form part of the invention.