CAS: 105-50-0; Diethyl 1,3-Acetonedicarboxylate

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32328-03-3 542-05-2 4949-44-4

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CAS号77-92-9 柠檬酸 | CAS号64-17-5 乙醇 | CAS号542-05-2 1,3-丙酮二羧酸 | CAS号463-51-4 乙烯酮 | CAS号1663-67-8 丙二酰氯 | CAS号115996-74-2 3-carboxymethyl... | CAS号95-92-1 草酸二乙酯 | CAS号67-64-1 丙酮 | CAS号77570-27-5 ethyl 3-amino-3... | CAS号5780-52-9 1,1,5,5-tetrach... | CAS号107836-75-9 4,6-二氯烟酰氯 | CAS号32328-03-3 3-羟基戊二酸二乙酯 | CAS号500-67-4 5-庚基苯-1,3-二醇 | CAS号40296-46-6 4,6-二氯烟酸乙酯 | CAS号144-62-7 草酸 | CAS号503-66-2 3-羟基丙酸 | CAS号533-62-0 3-羟基谷氨酸 | CAS号480-96-6 苯并氧化呋咱

1,3-丙酮二羧酸 反应生成1,3-丙酮二羧酸二乙酯
参考文献:Hemostatic Markers And Renal Function After Cardiopulmonary Bypass
标题:Hemostatic Markers And Renal Function After Cardiopulmonary Bypass
摘要:为评估心肺转流后的凝血状态及其与肾功能的关系,测定了46名接受冠状动脉搭桥手术的患者中的凝血标志物--凝血酶抗凝血酶iii复合物和凝血酶原片段1+2.术后血清肌酐值超过20 Mg.l−1的12名患者表明肾功能受损;这些患者术后凝血标志物水平显著增加.这些数据表明心肺转流后出现肾功能障碍的患者存在血栓倾向.建议在这类患者中进行抗凝治疗.
Doi:10.1177/021849230100900203

专利信息

专利号:US-7462714-B2
优先权日:2002-09-24
标题 :Process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
发明人：VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I): n nApplication to the synthesis of bivalent salts of ranelic acid and more especially strontium ranelate and its hydrates.

专利号:US-4287123-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.

专利号:US-4282148-A
优先权日:1980-01-14
标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4414155-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-7214805-B2
优先权日:2002-09-24
标题:Process for the industrial synthesis of strontium ranelate and its hydrates
发明人：VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL
权利人:SERVIER LAB
摘要:The process for the industrial The synthesis of strontium ranelate of formula (I): n nand its hydrates.

专利号:US-2025162968-A1
优先权日:2022-02-02
标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids
发明人：ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A
权利人:NANOVATION THERAPEUTICS INC
摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.