CAS: 108-56-5; Diethyl 2-Oxobutanedioate

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Sodium 1,4-Diethoxy-1,4-Dioxobut-2-En-2-Olate置于盐酸体系中,用 乙醚,水 用作溶剂,以83%的收率获得草酰乙酸二乙酯
参考文献:吡咯烷酮衍生物作为趋化因子受体的细胞内变构调节剂:Cc趋化因子受体1和2的选择性和双重靶向抑制剂.
标题:吡咯烷酮衍生物作为趋化因子受体的细胞内变构调节剂:Cc趋化因子受体1和2的选择性和双重靶向抑制剂.
摘要:Cc趋化因子受体2和9(ccr2和ccr9)的最新晶体结构为变构细胞内结合位点提供了结构证据.该位点涉及的残基高度保守,表明其存在于大多数趋化因子受体中,包括紧密同源的ccr1.通过使用[ 3 H] Ccr2-Ra-[ R ],一种高亲和力的ccr2细胞内配体,我们报道了ccr1的细胞内结合位点,其中该放射性配体也以高亲和力结合.此外,我们报告了一系列针对ccr1和ccr2的吡咯烷酮衍生物的合成和生物学特性,这使我们能够鉴定出几种高亲和力的细胞内配体,包括选择性和潜在的多靶点拮抗剂.评估功能性化合物中的所选化合物35 S]Gtpγs分析表明,它们在ccr1中起反向激动剂的作用,提供了一种新的药理调节方式.因此,这种细胞内结合位点使得能够设计选择性和多靶点抑制剂作为一种新颖的治疗方法.
Doi:10.1021/acs.Jmedchem.8B00605

专利信息

专利号:US-4136033-A
优先权日:1969-11-07
标 题:6-hydroxypyridone-2 compounds having a cationic group in the 3-position
发明人：STEINEMANN WILLY
权利人:SANDOZ LTD
摘要:Compounds of the formula ##STR1## wherein K.sup.⊕ is a cationic group, preferably heterocyclic, n R is hydrogen or an organic radical, preferably alkyl, phenyl or acyl, n R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, substituted heterocyclyl, amino or substituted amino, and n A.sup.⊖ is an anion, n Are useful as intermediates in the synthesis of azo dyes of the formula ##STR2## wherein D is an aromatic carbocyclic or heterocyclic diazo component radical, and n K.sup.⊕, r, r 1 and A.sup.⊖ are as defined above.

专利号:US-2748135-A
优先权日:1954-04-29
标题:Intermediates for the synthesis of pyridoxine
发明人：JONES REUBEN G
权利人:LILLY CO ELI

专利号:GB-660019-A
优先权日:1947-11-01
标 题:Improvements in or relating to synthesis of beta-substituted propionaldehydes

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优先权日:2010-01-26
标题 :Intermediates for the synthesis of oxygen-substituted 3-heteroaroylamino-propionic acid derivatives

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优先权日:2021-10-26
标题:A kind of coumarin type two-photon initiator and its synthesis method and application

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优先权日:2024-02-29
标 题:Synthesis and application of novel polyester based on dihydroxybenzophenone as starting material