CAS: 118-41-2; 3,4,5-Trimethoxybenzoic Acid

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CAS号3840-31-1 3,4,5-三甲氧基苯甲醇 | CAS号86-81-7 3,4,5-三甲氧基苯甲醛 | CAS号201230-82-2 carbon monoxide | CAS号143287-98-3 (3,4,5-trimetho... | CAS号1916-07-0 3,4,5-三甲氧基苯甲酸甲酯 | CAS号149-91-7 没食子酸; 3,4,5-三羟基苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号211429-78-6 tert-butyl 3,4,... | CAS号75-91-2 叔丁基过氧化氢 | CAS号188493-61-0 3,4,5-trimethox... | CAS号5081-42-5 2-硝基-3,4,5-三甲氧基苯甲酸甲酯 | CAS号554-92-7 盐酸三甲氧苯酰胺 | CAS号4521-61-3 3,4,5-三甲氧基苯甲酰氯 | CAS号5035-82-5 3,4,5-三甲氧基氨基苯甲酸甲酯 | CAS号39068-88-7 2,3,4-三甲氧基-6-甲基苯酚 | CAS号605-94-7 2,3-二甲氧基-5-甲基-1,4-苯醌 | CAS号3291-03-0 3,4,5-三甲氧基苯甲酰肼 | CAS号14779-44-3 4-ethoxy-3,5-di... | CAS号14588-61-5 3,5-dimethoxy-4... | CAS号6638-05-7 甲基丁香酚

3,4,5-三甲氧基苄胺置于叔丁基过氧化氢体系中,化学反应 5.0H,以86%的收率获得3,4,5-三甲氧基苯甲酸
参考文献:N-杂环与苄胺的氧化剂控制的c-Sp 2 / Sp 3-h交叉脱氢偶联
标题:N-杂环与苄胺的氧化剂控制的c-Sp 2 / Sp 3-h交叉脱氢偶联
摘要:苄基胺与具有sp 2或sp 3碳的n-杂环的氧化剂控制的离子液体介导的交叉脱氢偶联(cdc)导致c-苯甲酰化或烯基化产物的形成.N-杂环的苯甲酰化是通过(nh 4)2 S 2 O 8催化的苯甲酰基基团形成的.具有c-Sp 3碳的n-杂环(2-甲基氮杂芳烃)的氧化烯基化反应通过苄胺的脱氨基反应,然后以高立体选择性进行c-Sp 3-H键活化而进行的.苯甲酰化和烯基化方案均不含金属,绿色,简单,有效,并且可耐受多种官能团.
Doi:10.1021/acs.Joc.7B00856

专利信息

专利号:US-2015057366-A1
优先权日:2012-03-05
标题 :Synthesis of elemicin and topical analgesic compositions
发明人：LA GRANGE MARTIN JAMES
权利人:LA GRANGE MARTIN JAMES
摘要:The present invention is directed to the synthesis of elemicin and its isomeric form, and their use in topical analgesic formulations, including for dental and veterinary use. Various compositions include gels, films, dressings, cavity filling gels, having analgesic and/or antifungal properties.

专利号:US-7468438-B2
优先权日:2004-03-25
标题:Process for the semisynthesis of deserpidine
发明人：FONTANA GABRIELE; BOMBARDELLI EZIO; SAMORI CRISTIAN; BALDELLI ELEONORA; GUERRINI ANDREA; BATTAGLIA ARTURO; DANIELI BRUNO
权利人:INDENA SPA
摘要:The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-5856107-A
优先权日:1997-02-04
标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
发明人：OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.