合成目标产物 Methyl Valeraldehyde 主要起始原料 Carbon Monoxide And Trans-2-Pentene
(文献来源)合成步骤主要原料 Carbon Monoxide 和 Trans-2-Pentene
1-甲氧基-2-甲基戊烷-2-醇置于磷酸体系中,化学反应 3.0H,以83%的收率获得2-甲基戊醛 参考文献:Duchene,Alain; Mouko-Mpegna,David; Quintard,Jean-Paul,Bulletin De La Societe Chimique De France,1985,# 5,P. 787-793 标题:Duchene,Alain; Mouko-Mpegna,David; Quintard,Jean-Paul,Bulletin De La Societe Chimique De France,1985,# 5,P. 787-793
专利号:US-5484949-A 优先权日:1993-01-29 标题:Method for the synthesis of α β-unsaturated ketones 发明人:TSUKASHIMA KEIICHI; NAKAJIMA MASASHI; FUJIMARU MASAYOSHI; SUZUKI KENJI 权利人:NIPPON SODA CO 摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula reacting aldehydes represented by general formula R1CHO (where R1 is as defined above) with alkali metal salt of acetoacetic acid represented by general formula sence as a catalyst of 3-azabicyclo[3,2,2]nonane, a cyclic secondary amine represented by general formula (1) (1) a cyclic secondary amine represented by general formula (2) (2) (where, l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R3 is a lower alkyl group, its substitution position is at a carbon atom other than two those adjacent to N, and is an alicyclic group or a phenol group), or a secondary amine represented by general formula (3) CH3NHCH2R4(3) in a mixuture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting an amount of water.
专利号:US-6680395-B2 优先权日:2000-03-04 标 题:Method for the synthesis of straight-chain aliphatic carboxylic acids from aldehydes 发明人:SPRINGER HELMUT 权利人:CELANESE CHEM EUROPE GMBH 摘要:The invention relates to a non-catalysed method for the synthesis of straight-chain aliphatic carboxylic acids by oxidation of straight-chain aldehydes with oxygen-containing gas mixtures. The invention is characterised in that during the novel process of oxidation branched aldehydes are present in the reaction mixture.
专利号:US-2023212788-A1 优先权日:2020-03-26 标 题:New method for automated on-demand biomolecular array synthesis 发明人:ZHANG YIXIN; LIN WEILIN 权利人:UNIV DRESDEN TECH 摘要:The invention provides an amphiphilic coating for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, comprising a hydrophilic chemical structure and a lipophilic group, wherein said peptides and small molecular compounds differ from spot to spot from each other in the chemical structure, characterized in that said amphiphilic coating possesses low wettability to polar aprotic solvents used in the array synthesis; said amphiphilic coating possessing low wettability is designed that it can be converted to a coating possessing high wettability by hydrolysis of the lipophilic group; and said amphiphilic coating comprises an amino group for the reaction with an electrophilic reagent. The invention further provides a solid support comprising said amphiphilic coating and a method for method for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, wherein said planar surface of a solid support comprises said amphiphilic coating. Said method includes the enhancing of the wettability of a glass surface to organic solvents to realize automated on-demand biomolecular array synthesis comprising both, peptides and small molecular compounds. The amphiphilic surface can be switched to a hydrophilic surface, resulting in high density arrays suitable for protein- and cell-based screening.
专利号:WO-2024259491-A1 优先权日:2023-06-23 标 题:New synthesis method 发明人:FORD DANIEL; POZNAKS VIKTORS; FOTINS JURIS; ÄŒERÅ…AKS DMITRIJS 权利人:THE HEART RES INSTITUTE LTD 摘要:The present disclosure generally relates to a process for the synthesis of AZD6482. In particular, the present disclosure also relates to a process for the synthesis of enantiomerically pure AZD6482. The present disclosure also relates to a process for the synthesis of enantiomerically pure intermediates. The present disclosure also relates to compounds prepared by the processes and the use of such compounds to prepare compositions and to treat disorders.
专利号:US-8557979-B2 优先权日:2004-06-10 标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation 发明人:CHOI WOO-BAEG; KOWALIK EWA 权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC 摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.
专利号:US-9403841-B2 优先权日:2012-01-25 标题:Phragamalin limonoids for the treatment of sexual dysfunction 发明人:WIKBERG JARL; JIRGENSONS AIGARS; LIEPINSH EDVARDS 权利人:DICOTYLEDON AB 摘要:The present invention relates to novel chemical compounds, to methods for synthesis of such compounds, and to the use of these novel compounds in the synthesis of other chemical compounds that, inter alia, may be used in the treatment of sexual dysfunction, and for eliciting enhancing effects on sexual behavior. The invention also relates to remarkable biological properties of the novel compounds in their capacity of inducing aggressive behavior.
参考标题:Total Synthesis Of (−)-Sarain A 作者:Michael H. Becker,Peter Chua,Robert Downham,Christopher J. Douglas,Neil K. Garg,Sheldon Hiebert,Stefan Jaroch,Richard T. Matsuoka,Joy A. Middleton,Fay W. Ng,Larry E. Overman |发布日期:2007.10.1 摘要:Studies Toward The Complex Marine Alkaloid Sarain A. Various Strategies Were Conceived, Setbacks Encountered, And Solutions Developed, Ultimately Leading To A Successful Enantioselective Total Synthesis. Our Route To (+)-Sarain A Features A Number Of Key Steps, Including An Asymmetric Michael Addition To Install The C4'-C3'-C7' Stereotriad, An Enoxysilane-N-Sulfonyliminium Ion Cyclization To Set The C3 Quaternary
合成参考文献
摘要:Mase, N., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 176. 摘要:Jie, X.; Su, W., Science of Synthesis, (2022) , 11. 摘要:Xu, L.; Wu, X.; Xiao, J., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 297. 摘要:Wu, X.; Xiao, J., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 268. 摘要:Inokuma, T.; Takemoto, Y., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 445.