CAS: 136514-17-5; 2,3,6-Trifluorobenzonitrile

相似化合物

104451-70-9 2358-29-4 207986-22-9

上下游产品

CAS号2358-29-4 2,3,6-三氟苯甲酸 | CAS号230295-09-7 2,3,6-三氟苄胺

2,3,6-三氟苯甲醛置于ammonium Hydroxide,碘体系中,用 2-甲基四氢呋喃 用作溶剂,化学反应生成2,3,6-三氟苯腈
参考文献:Morphic Forms Of A Mutant Braf Degrader And Methods Of Manufacture Thereof
标题:Morphic Forms Of A Mutant Braf Degrader And Methods Of Manufacture Thereof
摘要:Advantageous Isolated Morphic Forms Of (3R)-3-[6-[2-Cyano-3-[[ethyl(Methyl)Sulfamoyl]Amino]-6-Fluorophenoxy]-4-Oxoquinazolin-3-Yl]-8-[2-[l-[3-(2,4-Di Oxo-1,3-Diazinan-L-yl)-5-Fluoro-1-Methylindazol-6-Yl]-4-Hydroxypiperidin-4-Yl]Acetyl]-1-Oxa-8-Azaspiro[4.5]Decane (Compound 1),Which Is A Mutant Braf Degrader,And Methods To Prepare Compound 1 Morphic Forms For Therapeutic Applications Are Provided In The Invention. The Invention Also Provides Improved Methods For The Synthesis Of Compound 1,New Pharmaceutical Compositions Comprising Compound 1,And New Uses Of Compound 1.

专利信息

专利号:US-2025289827-A1
优先权日:2022-12-02
标 题:Morphic forms of a mutant braf degrader and methods of manufacture thereof
发明人：YU ROBERT T; HE MINSHENG; SCHNADERBECK MATTHEW J; KREGER BRIDGET; POLLOCK ROY MACFARLANE; JIANG SIYI; LI MEIQI; CHEN BOLU; LU JIANNAN
权利人:C4 THERAPEUTICS INC
摘要:Advantageous isolated morphic forms of (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane (Compound 1), which is a mutant BRAF degrader, and methods to prepare Compound 1 morphic forms for therapeutic applications are provided in the invention. The invention also provides improved methods for the synthesis of Compound 1, new pharmaceutical compositions comprising Compound 1, and new uses of Compound 1.

专利号:CN-111377826-A
优先权日:2020-03-23
标 题 :A kind of green synthesis process of quinolone key intermediate

专利号:US-12428380-B2
优先权日:2023-06-28
标 题 :Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.

专利号:CN-111377826-B
优先权日:2020-03-23
标 题 :Green synthesis process of key intermediate of quinolone