CAS: 141315-50-6; (S)-2-Amino-2-(2-Chlorophenyl)Acetic Acid

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CAS号225918-54-7 (S)-α-(2-chloro... | CAS号144457-28-3 氯吡格雷羧酸

2-氯苯基氧乙酸置于amino Acid Dehydrogenase From Bacillus Clausii,还原型辅酶ⅰ体系中,用 Aq. Buffer 用作溶剂,化学反应生成(S)-2-氯苯甘氨酸
参考文献:使用新发现的克劳氏芽孢杆菌†氨基酸脱氢酶 有效获得1-苯基甘氨酸
标题:使用新发现的克劳氏芽孢杆菌†氨基酸脱氢酶 有效获得1-苯基甘氨酸
摘要:由氨基酸脱氢酶克劳氏芽孢杆菌(bc Aadh)被确定并在过表达大肠杆菌bl21(de3)用于制备的大号从苯甲酰甲酸-苯基甘氨酸.将重组bc Aadh纯化至均质并进行表征.在最佳ph值为9.5和10.5时,Bc Aadh可以催化还原胺化和氧化脱氨作用.此外,Bc Aadh具有广泛的底物谱,显示出对各种芳族和脂族酮酸的活性.当与巨大芽孢杆菌的葡萄糖脱氢酶共表达时,Bc Aadh在制备大芽孢杆菌中的潜在应用.在高底物负载和低生物催化剂添加下研究了l-苯基甘氨酸.在> 99.9%ee的6小时内,多达400 Mm的苯甲酰甲酸可被完全还原为l-苯基甘氨酸.仅用0.5G Dcw L-1,就完全还原了200 Mm苯甲酰基甲酸,从而使底物与生物催化剂的比例为60 Gg-1,环境因子为4.7,克级分离产率为91.7%.这项研究为bc Aadh在手性非天然氨基酸合成中的应用提供了指导.
Doi:10.1039/c6Ra17683F

专利信息

专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人：YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:WO-2017070418-A1
优先权日:2015-10-22
标 题:Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products

专利号:CN-108349879-A
优先权日:2015-10-22
标题:Synthesis of cyclohexanecarboxamide derivatives useful as sensates in consumer products

专利号:JP-2018531948-A
优先权日:2015-10-22
标 题 :Synthesis of cyclohexanecarboxamide derivatives useful as sensory agents in consumer products

专利号:US-2017057911-A1
优先权日:2015-10-22
标 题:Synthesis of aryl cyclohexane carboxamide derivatives useful as sensates in consumer products

专利号:CN-114507650-A
优先权日:2022-01-28
标 题 :Leucine dehydrogenase mutant and application thereof in synthesis of (S) -o-chlorophenylglycine