CAS: 16867-03-1; 2-Amino-3-Hydroxypyridine

相似化合物

902835-93-2 15128-82-2 55717-46-9

上下游产品

CAS号6332-56-5 2-羟基-3-硝基吡啶 | CAS号680-31-9 六甲磷酰三胺(HMPA) | CAS号611-13-2 2-糠酸甲酯 | CAS号609-38-1 2-糠酰胺 | CAS号874-24-8 3-羟基-2-吡啶甲酸 | CAS号15128-82-2 3-羟基-2-硝基吡啶 | CAS号24016-03-3 2-氨基-3-苄氧基吡啶 | CAS号10006-74-3 3-乙氧基吡啶-2-胺 | CAS号933-90-4 3-羟基吡啶酰胺 | CAS号40263-57-8 2-碘-3-羟基吡啶 | CAS号104711-71-9 2-Propyl[1,3]ox... | CAS号106840-72-6 ethyl N-(3-hydr... | CAS号111852-42-7 2-(4-bromopheny... | CAS号35575-96-3 甲基吡啶磷 | CAS号35570-68-4 6-氯恶唑并[4,5-b]吡啶... | CAS号31354-48-0 N-(3-羟基吡啶-2-基)乙酰胺 | CAS号40926-66-7 恶唑并[4,5-b]吡啶-2-胺 | CAS号40966-87-8 2-氨基-3-羟基-5-氯吡啶 | CAS号143141-25-7 2-丙基-1H-吡咯并[2,3-B]吡啶 | CAS号39903-01-0 2-羟基-3-氨基-5-溴吡啶

3-羟基吡啶酰胺置于sodium Hypobromide体系中,化学反应生成2-氨基-3-羟基吡啶
参考文献:Bray Et Al.,Biochemical Journal,1950,Vol. 46,P. 506
标题:Bray Et Al.,Biochemical Journal,1950,Vol. 46,P. 506

专利信息

专利号:US-2008214809-A1
优先权日:2006-08-23
标 题 :Process for the synthesis of CMHTP and intermediates thereof
发明人：DOLITZKY BEN-ZION; SHAPIRO EVGENY; INI SANTIAGO; SHMUELY YARON; LANCRY ELI; PILARSKY GIDEON
权利人:DOLITZKY BEN-ZION; SHAPIRO EVGENY; INI SANTIAGO; SHMUELY YARON; LANCRY ELI; PILARSKY GIDEON
摘要:The present invention provides processes of preparing 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone, wherein the processes use 3-(2-chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMBP) and/or 3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) having phosphorus at least partially removed as the intermediate.

专利号:US-7820816-B2
优先权日:2006-08-23
标题:Process for the synthesis of CMHTP and intermediates thereof
发明人：DOLITZKY BEN-ZION; SHAPIRO EVGENY; INI SANTIAGO; SHMUELY YARON; LANCRY ELI
权利人:TEVA PHARMA
摘要:The present invention provides 3-benzyloxy-2-aminopyridine (BOPA), 3-(2-Hydroxyethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (HMBP), 3-(2-Chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone. The present invention also provides processes for preparing these intermediates and for preparing paliperidone.

专利号:US-8940749-B2
优先权日:2011-05-31
标题:Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydor-9-hydroxy-2-methyl-4H-pyrido[ 1, 2-A]-pyrimidin-4-one(paliperidone) and paliperidone palmitate
发明人：DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; NEELA PRAVEEN KUMAR; BATTHINI GURUSWAMY; VENKATA NARASIMHARAO TELAGAREDDY; RAVANABABU KOSIREDDY; SUDHEER KALLEPALLY
权利人:DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; NEELA PRAVEEN KUMAR; BATTHINI GURUSWAMY; VENKATA NARASIMHARAO TELAGAREDDY; RAVANABABU KOSIREDDY; SUDHEER KALLEPALLY
摘要:An improved process for the synthesis of 3-[2-[4-((6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one (Paliperidone) and Paliperidone Palmitate through a novel intermediate (2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido [1,2-a]pyrimidine-4-one Palmitate ester.

专利号:US-5001136-A
优先权日:1990-06-07
标 题 :Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hydroxy or alkoxy)pyridines
发明人：WALKER FREDERICK J
权利人:PFIZER
摘要:2-substitutedmethylamino-amino 5-(hydroxy or alkoxy) pyridines and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, dermatological, allergic and cardiovascular diseases.

专利号:US-2006004188-A1
优先权日:2000-09-29
标 题:Intermediates and the synthesis of modified carbocyanine dyes and their conjugates

专利号:US-8653223-B2
优先权日:2008-04-16
标题:Transketalized compositions, synthesis, and applications
发明人：SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.