CAS: 19715-19-6; 3,5-Bis-Tert-Butylsalicylic Acid

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CAS号124-38-9 二氧化碳 | CAS号96-76-4 2,4-二叔丁基酚 | CAS号15018-03-8 methyl 3,5-dite... | CAS号119-36-8 水杨酸甲酯 | CAS号100-97-0 乌洛托品 | CAS号20834-61-1 2-溴-4,6-二-叔-丁基苯酚 | CAS号37408-22-3 potassium 2,4-d... | CAS号16373-02-7 2,4-ditert-buty... | CAS号37456-29-4 1-[3,5-二(叔丁基)-2... | CAS号24242-58-8 (3,5-ditert-but... | CAS号810669-72-8 2,4-ditert-buty...

水杨酸甲酯置于硫酸体系中,用 甲醇,水 用作溶剂,化学反应 10.0H,反应生成3,5-二叔丁基水杨酸
参考文献:区域特异性取代的 (R)-和 (S)-恶唑基苯酚的实用途径
标题:区域特异性取代的 (R)-和 (S)-恶唑基苯酚的实用途径
摘要:从水杨酸衍生物 4-7 和各种对映异构纯 1,2-氨基醇 13A-D 开始,通过两条互补路线 A 和 B 制备了新的,不同取代的酚恶唑啉 14A-D 和 15A-D.在路线 A 中,使用 Appel 反应将 1,2-氨基醇 13A-D 与水杨酸 5 和 7 直接缩合,而在路线 B 中,氨基醇 13B-D 用 2-羟基苯甲腈 4 和 6 处理,置于witte-Seeliger 条件下.后一条路线有利于 L-缬氨醇 13B 和 L-叔亮氨醇 13C,而路线 A 是由 D-和 L-丝氨酸制备的新的,空间要求高的氨基醇 13A 的首选方法.水杨酸衍生物5和6中的硝基通过用硝酸对叔丁基进行区域特异性同位取代而引入.
Doi:10.1002/1099-0690(200108)2001:16<3067::Aid-Ejoc3067>3.0.Co;2-0

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:EP-1783123-B1
优先权日:2004-06-25
标题 :Synthesis of polyoxygenated nitrogen systems, comprising reactions between enamines of 1,3-dioxan-5-ones and nitroolefins
发明人：ALONSO ALONSO R; OZORES VITURRO L; CAGIDE FAGIN F; ORTIZ LARA J C
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The invention relates to the synthesis of polyoxygenated nitrogen systems, comprising reactions between enamines of 1,3-dioxan-5-ones and nitroolefins. More specifically, the invention relates to the reaction between enamines having formula II which are derived from 1,3-dioxan-5-ones I and nitroolefins having formula III. In this way, novel polyoxygenated nitrogen systems are generated having formula IV and V, which, as they are or following simple transformations, constitute synthetic intermediates and/or analogues of different systems of proven biological/pharmacological interest, such as certain antibiotics, or tetrodotoxin, pancratistatin or the analogues thereof. The aforementioned reactions involve the use of enamines II in Michael-type addition reactions and in direct annealing processes with double acceptor systems at relative positions 1, 3. Said N acceptors include nitroolefins III, wherein R = CHO (alphanitroenals). The invention also relates to the preparation thereof, which is based on the oxidation of the corresponding precursor alcohols VII, and the use of same in annealing processes.

专利号:US-5599963-A
优先权日:1994-09-21
标题:Catalysts for production of β-hydroxy carbonyl compounds
发明人：CARREIRA ERICK M; SINGER ROBERT A
权利人:CALIFORNIA INST OF TECHN
摘要:The invention relates to catalysts for the synthesis of beta -hydroxy carbonyl compounds, and in particular to enantioselective catalysts.

专利号:EP-1440977-B1
优先权日:2003-01-24
标 题:Improved process for the preparation of diamidic derivatives of the tripeptid KPV
发明人：GENARD SYLVIE
权利人:OREAL
摘要:A multi-stage, solution-phase synthesis of KPV (lysine-proline-valine) tripeptide diamide derivatives (I) is claimed, starting from an N,N'-diprotected lysine compound (II) and an optionally carboxy-protected proline compound (III) and utilizing specific combinations of protecting groups. Some compounds (I) are new. Solution-phase synthesis of KPV (lysine-proline-valine) tripeptide diamide derivatives of formula (I) or their salts involves: (a) reacting a diprotected lysine compound of formula P2-N-(CH2)4-C(NH-P1)-CO2H (II) (optionally salified with a mineral or organic base) and an optionally protected proline compound of formula (III) (optionally salified with a mineral or organic acid) in presence of an activating or coupling reagent in a solvent to give a protected dipeptide of formula (IV) (in either order); (b) coupling the C-terminal of the proline residue of (IV; P3 = OH) with a valinamide compound of formula Me2CH-CH(NH2)-CONR2R3 (V) (optionally salified with a mineral or organic acid) and (b) coupling the alpha-amino group of the N-terminal proline residue of (IV) with an acid chloride or anhydride of formula CR1R'1R''1-CO-Cl (VIA) or (CR1R'1R''1-CO)2-O (VIB); and (c) cleaving the protecting group P2 in the obtained protected tripeptide of formula (XII). R1, R'1, R''1 = H; 1-22C alkyl (optionally interrupted by a heteroatom such as O, N, S or Si); 4-10C cycloalkyl; 1-22C per- or polyfluoroalkyl; aryl (optionally substituted by one or more of halo and/or 1-4C alkyl); or aralkyl; or CR1R'1R''1 = 3-7 membered saturated ring (optionally substituted by one or more 1-4C alkyl and optionally containing a heteroatom such as O, S or N); R2, R3 = 1-24C alkyl (optionally interrupted by a heteroatom such as O, N, S or Si); 4-10C cycloalkyl; 1-22C per- or polyfluoroalkyl; aryl (optionally substituted by one or more of halo and/or 1-4C alkyl); or aralkyl; or NR2R3 = 5- or 6-membered saturated ring (optionally substituted by one or more 1-4C alkyl and optionally containing an additional heteroatom such as O, S or N); P1, P2 = different protecting groups; P3 = protecting group (different from P1 and P2) or OH; Provided that neither of CR1R'1R''1-CO- and NR2R3 is the residue of an aminoacid or peptide. An Independent claim is included for (I) and their salts as new compounds, provided that at least one of R1, R'1 and R''1 is other than H and at least one of R2 and R3 is other than H.

专利号:EP-1080095-B1
优先权日:1998-03-12
标 题:Modulators of protein tyrosine phosphatases (ptpases)
发明人：MOLLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTP.alpha., LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人：NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.