CAS: 22232-54-8; Ethyl 3-Methyl-2-Thioxo-2,3-Dihydro-1H-Imidazole-1-Carboxylate

上下游产品

CAS号616-47-7 N-甲基咪唑 | CAS号541-41-3 氯甲酸乙酯 | CAS号60-56-0 甲巯咪唑 | CAS号497-98-3 Carbonothioic a... | CAS号110-86-1 吡啶 | CAS号60-29-7 乙醚 | CAS号628-13-7 吡啶盐酸盐 | CAS号61640-28-6 1-ethyl-3-methy... | CAS号50968-13-3 2-ethylsulfanyl...

在 三乙胺,Sulfur体系中,用 四氢呋喃 用作溶剂,化学反应 24.0H,以0.44 G的收率获得卡比吗唑
参考文献:Antithyroid Drug Carbimazole And Its Analogues: Synthesis And Inhibition Of Peroxidase-Catalyzed Iodination Of L-Tyrosine
标题:Antithyroid Drug Carbimazole And Its Analogues: Synthesis And Inhibition Of Peroxidase-Catalyzed Iodination Of L-Tyrosine
摘要:Synthesis And Biological Activity Of The Antithyroid Drug Carbimazole (Cbz) And Its Analogues Are Described. The Introduction Of An Ethoxycarbonyl Group In Methimazole And Its Selenium Analogue Not Only Prevents The Oxidation To The Corresponding Disulfide And Diselenide But Also Reduces The Zwitterionic Character. A Structure-Activity Correlation In A Series Of Cbz Analogues Suggests That The Presence Of A Methyl Substituent In Cbz And Related Compounds Is Important For Their Antithyroid Activity.
Doi:10.1021/jm800894M

专利信息

专利号:US-8933207-B2
优先权日:2010-07-28
标 题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C
权利人:CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C; SMARTCELLS INC
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk 1 , Alk 2 , and W are as defined and described herein.

专利号:US-2013131310-A1
优先权日:2010-07-28
标题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：KANE JOHN; LANCASTER THOMAS M; ZION TODD C
权利人:KANE JOHN; LANCASTER THOMAS M; ZION TODD C
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein each of X, Alk, and W are as defined and described herein.