CAS: 32862-97-8; 3-(3-Bromophenyl)Acrylic Acid

该化合物其结构特征为该化合物其结构特征为一种丙基酸脊柱,以溴苯基组替代,该化合物通常具有芳香和不饱和的碳酸的特性,在室温下可能是一种固体,由于溴苯基细胞的疏水性,水中的溶解性较低,但可能会在乙醇或丙酮等有机溶剂中溶解.溴原子的存在具有显著的电阴性特征,影响该化合物在有机合成中的再活动性和潜在应用,特别是在制药或农用化学产品方面.此外,丙基酸功能组还允许有可能参与各种化学反应,包括聚合和酯化.在处理时,应参考安全数据,因为卤化化合物可能对健康造成危害.总的来说,这种化合物在学术和工业化学方面都有意义.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

m-amin°Cinnamic acid m-bromobenzoic aldehyde acetic anhydride 3-nitro-benzaldehyde 3-(3-bromophenyl)propanoic acid 3-sulfo-cinnamic acid m-bromobenzoic aldehyde ethyl 3-bromo-cinnamate

合成工艺路线路线简述

  • 275826-35-2 = 32862-97-8 + 82311-69-1
    反应条件:1.1 Catalysts: Phenylalanine Ammonia-Lyase,Aminomutase,Phenylalanine 2,3- Solvents: Water; 24 H,Ph 8,30 °C
    标题:Kinetic Resolution Of Aromatic β-Amino Acids Using A Combination Of Phenylalanine Ammonia Lyase And Aminomutase Biocatalysts
    作者:Weise,Nicholas J.; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2017 卷标:359(9) 页码:1570-1576]

    141-82-2 + 3132-99-8 = 32862-97-8 + 82311-69-1
    反应条件:1.1 Reagents: Ammonium Formate Solvents: Ethanol; 4 H,Reflux2.1 Catalysts: Phenylalanine Ammonia-Lyase,Aminomutase,Phenylalanine 2,3- Solvents: Water; 24 H,Ph 8,30 °C
    标题:Kinetic Resolution Of Aromatic β-Amino Acids Using A Combination Of Phenylalanine Ammonia Lyase And Aminomutase Biocatalysts
    作者:Weise,Nicholas J.; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2017 卷标:359(9) 页码:1570-1576
M-Aminocinnamic Acid 反应生成3-溴肉桂酸
参考文献:Gabriel,Chemische Berichte,1882,Vol. 15,P. 2295
标题:Gabriel,Chemische Berichte,1882,Vol. 15,P. 2295

海关参考信息

专利信息


专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-3975429-A
优先权日:1973-11-05
标题:Cyclopropanemethyl esters of cinnamic acid and derivatives thereof
发明人:HENRICK CLIVE A; STAAL GERARDUS B
权利人:ZOECON CORP
摘要:Organic esters and thioesters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人:ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6989384-B2
优先权日:2000-06-14
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人:HUA YE; LUU HIEP THE; CHAN FORA P; JOHNSON JR THEODORE O; REICH SIEGFRIED HEINZ; SKALITZKY DONALD JAMES; YANG YI; HENDRICKSON THOMAS F; CHU SHAO SONG; EASTMAN BRIAN WALTER
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
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主要参考文献

[参考文献]: R J Perchalski, Et Al. Simultaneous Determination Of The Anticonvulsants, Cinromide (3-Bromo-N-Ethylcinnamamide), 3-Bromocinnamamide, And Carbamazepine In Plasma By High-Performance Liquid Chromatography. J Chromatogr. 1979 Jun 11;163(2):187-93.

合成参考文献


参考文献:10.1007/s11676-017-0532-2
摘要:Velmurugan N, Kalpana D, Cho JY, Lee YS. Chemical composition and antioxidant capacity of the aqueous extract of Phellodendron amurense. Journal of Forestry Research. 2017 Nov 07;29(4):1041–8. doi: 10.1007/s11676-017-0532-2.
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