CAS: 99291-25-5; (S)-3-(4-Phenylpiperazin-1-yl)Propane-1,2-Diol

上下游产品

CAS号92-54-6 N-苯基哌嗪 | CAS号50765-70-3 (S)-1-对甲苯磺酰氧基-2... | CAS号70987-78-9 (S)-(+)-对甲苯磺酸缩水甘油酯

在 Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 3.0H,以99%的收率获得产物左羟丙哌嗪
参考文献:苯酚官能化鏻盐催化环氧化物固定 Co2 的催化,动力学和机理见解
标题:苯酚官能化鏻盐催化环氧化物固定 Co2 的催化,动力学和机理见解
摘要:研究了一系列羟基官能化鏻盐作为双功能催化剂,用于在温和无溶剂条件下将co 2与环氧化物转化.在苯酚基碘化鏻存在下,反应通过相对于底物的一级反应动力学进行.值得注意的是,与脂肪族类似物相比,苯酚基催化剂没有表现出产物抑制.研究了反应速率的温度依赖性,并根据阿伦尼乌斯图确定了模型反应的活化能(e A =39.6 Kj Mol-1).还评估了底物范围.在优化的反应条件下,20个末端环氧化物在室温下转化为相应的环状碳酸酯,分离收率高达99%.该反应易于扩展,可在高达 50 G 底物的规模上进行.此外,该方法还应用于以环氧氯丙烷和苯基哌嗪为原料合成镇咳药氟哌嗪.此外,还进行了 Dft 计算,以合理化苯酚基碘化鏻催化剂的机理和高效率.计算证实了环氧化物通过碘化物盐的氢键活化,从而促进了开环步骤.值得注意的是,关于该步骤的有效吉布斯能垒对于溴化物是97 Kj Mol-1,对于碘化物盐是72 Kj Mol
DOI:10.1002/cssc.202002267

专利信息

专利号:FI-3818059-T3
优先权日:2018-07-02
标 题:Intermediates in the synthesis of C3-substituted cephalosporins

专利号:UA-73790-C2
优先权日:2000-07-28
标 题:2,2-DISPLACED 1,3-DIOXOLANES, METHOD FOR PRODUCING AND APPLICATION AS INTERMEDIATE PRODUCTS FOR SYNTHESIS OF APPROPRIATE (S) -ENANTHIOMERS AND (-) 3- (4-PHENYL-1-PIPERAZYNYLINYLENE-1)

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:US-2021290651-A1
优先权日:2020-03-20
标 题:Methods of treating viral infections using inhibitors of nucleotide synthesis pathways

专利号:US-2021308117-A1
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways

专利号:US-2021315880-A1
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways