CAS: 104-15-4; Toluene-4-Sulfonic Acid

• 英文名称Toluene-4-Sulfonic Acid
• 中文名称对甲苯磺酸
• IUPAC名称4-methylbenzenesulfonic acid
• 其它别名4-Methylbenzenesulfonic acid; Tosic acid; PTSA
• CAS编号104-15-4
• MFCD编号:MFCD00064387
• EINECS号:203-180-0
• FDA UNII编号:QGV5ZG5741
• 分子式:C7H8O3S
• 分子量:172.2
• 产品CID: 79776
• 产品分类有机原料 → 羧酸类化合物及衍生物 → 羧酸的卤化,磺化,硝化或亚硝化衍生物

• 相似结构搜索
• InChIKey: JOXIMZWYDAKGHI-UHFFFAOYSA-N
• InChI=1S/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

物理性质

• 熔点106~107 °C
• 沸点116 °C
• 闪点41 °C
• 密度1.3±0.1 g/cm3
• pKa:-0.43±0.50(预测)
• PSA:62.75
• LogP:0.93
• 折射率1.563
• 蒸汽压69.8Pa at 20°C
• 溶解性DMSO (Slightly), Methanol (Slightly)
• 敏感性1.与金属，强氧化剂，强碱，胺类，硝酸铵，三氟化氯，硝酸， 高锰酸盐，过氧化钠，过氧化氢，乙醛，酸（矿物，氧化，如铬酸，次氯酸，硝酸，硫酸） ，腐蚀剂（如氨，氢氧化铵，氢氧化钙，氢氧化钾，氢氧化钠） ，氯磺酸，发烟硫酸，溴五氟化，高氯酸，钾叔丁醇反应。 2.具有中等毒性。刺激皮肤、眼睛和黏膜。大鼠经口ＬＤ５０２４８０ｍｇ／ｋｇ，小鼠经口ＬＤ５０４００ｍｇ／ｋｇ。其钠盐无毒。生产过程中使用的甲苯具有毒性，对人体的肝和造血系统以及神经系统有损害。浓硫酸具有极强的腐蚀性，因此生产系统设备应保持良好的密闭性，防止泄漏，操作人员应穿戴防护用具。
• 外观形态透明无色至淡黄色溶液
• 储存条件惰性气氛,室温
• 产品应用医药上用作合成强力霉素,潘生丁,萘普生,阿莫西林,头孢羟氨苄中间体的重要原料,在有机合成工业中被广泛使用;在丙稀酸酯,纺织助剂,摄影胶片等生产中用作催化剂;在树脂,涂料,人造板,铸造,油漆行业被广泛用作固化剂,使用本厂产品,固化速度快,漆膜不变色. 本产品也是合成乙氧基喹啉的重要原料.在农药合成行业中也被广泛使用.贮运与防护:应贮存于通风干燥处,防止日晒,雨淋,露置于空气中易吸湿潮解.若吸湿后影响使用,可用离心机重新脱水或烘干.使用操作时避免与人体及衣物接触,若溅及人体或衣物应及时用水清洗.技术指标:
• 性质描述白色叶状或柱状结晶.熔点106-107°C,沸点140°C(2.67kPa).易溶于水,溶于醇和醚,难溶于苯和甲苯.该品有时以含1分子或4分子结晶水的形态存在.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  皮肤腐蚀 类别1C
  严重眼损伤 类别1
  皮肤腐蚀 类别1B
  急性毒性 类别4(经口)
  金属腐蚀物 类别1
  遇水放出易燃气体的物质 类别1
  生殖毒性 类别1B
  皮肤腐蚀 类别1A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H314 |造成严重皮肤灼伤和眼损伤.
  H318 |造成严重眼损伤.
  H302 |吞咽有害.
  H290 |可能对金属造成腐蚀.
  H260 |遇水放出易燃气体 可能会自燃.
  H360F |可能损害生育能力.
  H360 |可能损害生育能力或胎儿.
  H370 |损害器官.
• 防范说明P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• 危险等级8
• UN编号2584.0
• 危险品标志C
• 包装等级III
• 安全声明45-26-23
• 危险类别码34-10
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 104-15-4 = 104-15-4
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  标题:Highly Active Oligomeric (Salen)Co Catalysts For Asymmetric Epoxide Ring-Opening Reactions
  作者:Ready,Joseph M.; Jacobsen,Eric N.
  参考文献:Journal Of The American Chemical S°Ciety 日期:2001 卷标:123(11) 页码:2687-2688]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Acetone; 30 Min,Rt
  标题:Hydrogen-Bond-Assisted Organ°Catalytic Acetalization Of Secondary Alcohols: Experimental And Theoretical Studies
  作者:Rumyantsev,Misha; Sitnikov,Nikolay S.; Somov,Nikolay V.
  参考文献:Journal Of Physical Chemistry A 日期:2015 卷标:119(18) 页码:4108-4117]
  
  556-02-5 + 104-15-4 + 100-51-6 = 104-15-4 + 97984-62-8
  反应条件:1.1 Solvents: Benzene; 15 H,Reflux
  标题:Characterization Of Spatially Addressable Libraries: Stereoisomer Analysis Of Tetrahydro-β-Carbolines As An Example
  作者:Cheng,Cesar C.; Chu,Yen-Ho
  参考文献:Journal Of Combinatorial Chemistry 日期:1999 卷标:1(6) 页码:461-466]
  
  97990-19-7 + 80-48-8 = 104-15-4 + 97990-15-3
  反应条件:1.1 Solvents: Acetonitrile
  标题:Phot°Chemical Formation Of Methylenecyclopropane Analogs. 11. Phot°Chemical Elimination Of Nitrogen From Phenyl-Substituted 1,4-Dihydro-5-Imino-5H-Tetrazoles. Products Of Phenyl-Substituted Tris(Imino)Methane Diradicals
  作者:Quast,Helmut; Fuss,Andreas; Nahr,Uwe
  参考文献:Chemische Berichte 日期:1985 卷标:118(6) 页码:2164-85]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Methanol,Dichloromethane; 0 °C; 1 H,0 °C
  标题:Influence Of Anion-Binding Schreiner'S Thiourea On Dmap Salts: Synergistic Catalysis Toward The Stereoselective Dehydrative Glycosylation From 2-Deoxyhemiacetals
  作者:Ghosh,Titli; Mukherji,Ananya; Kancharla,Pavan K.
  参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(1) 页码:1253-1261]
  
  = 104-15-4
  反应条件:1.1 Solvents: Tetrahydrofuran; Rt
  标题:Synthesis,Self-Assembly,And Characterization Of Supramolecular Polymers From Electroactive Dendron Rodcoil Molecules
  作者:Messmore,Benjamin W.; Hulvat,James F.; Sone,Eli D.; Stupp,Samuel I.
  参考文献:Journal Of The American Chemical S°Ciety 日期:2004 卷标:126(44) 页码:14452-14458]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Ethyl Acetate; 4 H; Overnight,Cooled
  标题:Integration Of Upcycling And Closed-Loop Recycling Through Alternative Cyclization-Depolymerization
  作者:Tian,Guo-Qiang; Yang,Zheng-He; Zhang,Wei; Chen,Si-Chong; Chen,Li; Et Al
  参考文献:Green Chemistry 日期:2022 卷标:24(11) 页码:4490-4497]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Benzene; Heated
  标题:Chiral Compounds With Liquid Crystalline Nature And Ferroelectric Liquid Crystal Device Adopting The Same
  参考文献:World Intellectual Property Organization]
  
  = 104-15-4
  反应条件:1.1 Solvents: Tetrahydrofuran; Heated
  标题:Copper-Mediated Radiofluorination Of Aryl Pinacolboronate Esters: A Straightforward Prot°Col By Using Pyridinium Sulfonates
  作者:Antuganov,Dmitrii; Zykov,Michail; Timofeev,Vasilii; Timofeeva,Ksenija; Antuganova,Yulija; Et Al
  参考文献:European Journal Of Organic Chemistry 日期:2019 卷标:2019(5) 页码:918-922]
  
  = 104-15-4
  反应条件:1.1 Solvents: Tetrahydrofuran; 30 Min,Rt
  标题:Fluorescent Macromolecular Perylene Diimides Containing Pyrene Or Indole Units In Bay Positions
  作者:Dincalp,Haluk; Kizilok,Sevki; Icli,Siddik
  参考文献:Dyes And Pigments 日期:2010 卷标:86(1) 页码:32-41]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Toluene; 1 H,60 °C
  标题:Degradable Amino Acid-Based Poly(Ester Urea) Copolymer Adhesives
  参考文献:World Intellectual Property Organization]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Toluene; 24 H,Reflux
  标题:A Quantitative Assessment Of Chemical Perturbations In Thermotropic Cyanobiphenyls
  作者:Guerra,Sebastiano; Dutronc,Thibault; Terazzi,Emmanuel; Guenee,Laure; Piguet,Claude
  参考文献:Physical Chemistry Chemical Physics 日期:2016 卷标:18(21) 页码:14479-14494]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 10 Min,Rt
  标题:Manufacture Of Gel-Like Thin Films And Composite Membranes For Gas Separation
  参考文献:Japan]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Tetrahydrofuran; Rt
  标题:Monodisperse Cyclic Polymer Mechan°Chemistry: Scission Kinetics And The Dynamic Memory Effect With Ultrasonication And Ball-Mill Grinding
  作者:Noh,Jinkyung; Koo,Mo Beom; Jung,Jisoo; Peterson,Gregory I.; Kim,Kyoung Taek; Et Al
  参考文献:Journal Of The American Chemical S°Ciety 日期:2023 卷标:145(33) 页码:18432-18438]
  
  104-15-4 = 104-15-4 [标题:Reaction Conditions
  标题:Method For The Synthesis Of Polyethers
  参考文献:World Intellectual Property Organization]
  
  = 104-15-4
  反应条件:1.1 Solvents: Benzene
  标题:Multifunctional Zwitterionic Polymer Conjugates For Therapeutic Use
  参考文献:United States]
  
  104-15-4 = 104-15-4 [标题:Reaction Conditions
  标题:Brush-Like Poly(Ethylene Glycol) Grafting On Sio2 Nanoparticles With In-Situ Polymerization
  作者:Zhao,Yanhua; Chai,Changsheng
  参考文献:Surface And Interface Analysis 日期:2015 卷标:47(3) 页码:384-389]
  
  104-15-4 + 80875-98-5 + 100-51-6 = 104-15-4
  反应条件:1.1 Solvents: Toluene; 100 - 118 °C
  标题:Preparation Of Novel Crystalline η (Eta) Form Of Perindopril Erbumine
  参考文献:World Intellectual Property Organization]
  
  104-15-4 + 539820-41-2 = 104-15-4
  反应条件:1.1 Solvents: Acetic Acid; Rt1.2 Catalysts: Platinum; Rt1.3 Reagents: Hydrogen; 5 Bar,Rt1.4 Solvents: Toluene; Reflux
  标题:Method For Synthesis Of (2S,3As,7As)-Perhydroindole-2-Carboxylic Acid And Esters As Intermediates In The Synthesis Of Perindopril
  参考文献:European Patent Organization]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Pharmaceutical Intermediate For Synthesizing Ace Inhibitors And The Use Thereof
  参考文献:United States]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Preparation Of Amino Acid-Derived Intermediates In The Synthesis Of Ace Inhibitors
  参考文献:World Intellectual Property Organization]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Facile Synthesis Of Amino Acid Methyl Ester P-Toluenesulfonates With Methyl P-Toluenesulfonate
  作者:Ueda,Kazuo; Waki,Michinori; Izumiya,Nobuo
  参考文献:Memoirs Of The Faculty Of Science 日期:1984 卷标:14(2) 页码:307-12]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Synthesis,Structural,Spectroscopic,Mechanical,Linear And Nonlinear Optical Studies On 4-Dimethylaminopyridinium P-Toluenesulfonate: A Comparative Theoretical And Experimental Investigation
  作者:Sivaraj,G.; Et Al
  参考文献:Journal Of Molecular Structure 日期:2021 卷标:1240]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Synthesis And Characterization Of Versatile Amphiphilic Dendrimers Peripherally Decorated With Positively Charged Amino Acids
  作者:Alfei,Silvana; Et Al
  参考文献:Polymer International 日期:2018 卷标:67(11) 页码:1572-1584]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Corrigendum To "Sustained L°Calized Presentation Of Rna Interfering Molecules From In Situ Forming Hydrogels To Guide Stem Cell Osteogenic Differentiation" [biomaterials 35/24 (2014) 6278-6286] [erratum To D°Cument Cited In Ca161:090975]
  作者:Nguyen,Minh K.; Et Al
  参考文献:Biomaterials 日期:2017 卷标:125]
  
  = 104-15-4 + 88-20-0
  反应条件:1.1 Reagents: 2,4,6-Trimethylbenzenesulfonic Acid Solvents: Mesitylene
  标题:Sulfonating Agent And Pr°Cess
  参考文献:World Intellectual Property Organization]
  
  615-37-2 = 104-15-4 + 103675-61-2 + 88-20-0 + 103675-62-3
  反应条件:1.1 Reagents: Sulfuric Acid
  标题:Studies On The Sulfonation Of O-Iodotoluene
  作者:Muramoto,Yoshihiro; Et Al
  参考文献:Kinki Daigaku Kogakubu Kenkyu Hokoku 日期:1985 卷标:19 页码:27-32]
  
  72-18-4 = 104-15-4
  反应条件:1.1 Solvents: Benzene; Reflux
  标题:Using Peptidic Inhibitors To Systematically Probe The S1' Site Of Caspase-3 And Caspase-7
  作者:Goode,David R.; Et Al
  参考文献:Organic Letters 日期:2005 卷标:7(16) 页码:3529-3532]
  
  104-15-4 + 72-18-4 = 104-15-4
  反应条件:1.1 Solvents: Toluene; 24 H,Reflux
  标题:Design,Synthesis,And Evaluation Of Cystargolide-Based β-Lactones As Potent Proteasome Inhibitors
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  参考文献:European Journal Of Medicinal Chemistry 日期:2018 卷标:157 页码:962-977]
  
  104-15-4 = 104-15-4 + 45012-62-2
  反应条件:1.1 Solvents: Toluene; Reflux
  标题:Microwave-Enhanced Copper-Catalyzed N-Arylation Of Free And Protected Amino Acids In Water
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  参考文献:Journal Of Combinatorial Chemistry 日期:2007 卷标:9(2) 页码:204-209]
  
  = 104-15-4
  反应条件:1.1 Solvents: Methanol; 0.25 H,25 - 35 °C; 2 H,50 °C1.2 Reagents: Acetic Acid Solvents: Methanol; Ph 7.3,5 °C2.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  259214-57-8 = 104-15-4
  反应条件:1.1 Reagents: Sodium Hydroxide,Potassium Chloride Catalysts: Subtilisin Solvents: Acetone,Water; 91 H,Ph 8.1 - 8.3,35 - 37 °C1.2 Reagents: Hydr°Chloric Acid Solvents: Water; 75 H,Ph 2 - 3,Rt2.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  213316-49-5 = 104-15-4
  反应条件:1.1 Solvents: Methanol; 50 °C2.1 Reagents: Sodium Hydroxide,Potassium Chloride Catalysts: Subtilisin Solvents: Acetone,Water; 91 H,Ph 8.1 - 8.3,35 - 37 °C2.2 Reagents: Hydr°Chloric Acid Solvents: Water; 75 H,Ph 2 - 3,Rt3.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  213316-49-5 = 104-15-4
  反应条件:1.1 Reagents: Sodium Hydroxide,Potassium Chloride Catalysts: Subtilisin Solvents: Acetone,Water; 91 H,Ph 8.1 - 8.3,35 - 37 °C1.2 Reagents: Hydr°Chloric Acid Solvents: Water; 75 H,Ph 2 - 3,Rt2.1 Solvents: Methanol; 0.25 H,25 - 35 °C; 2 H,50 °C2.2 Reagents: Acetic Acid Solvents: Methanol; Ph 7.3,5 °C3.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  24424-99-5 = 104-15-4
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; 0.75 H,24 °C; 22 H,20 °C2.1 Solvents: Methanol; 0.25 H,25 - 35 °C; 2 H,50 °C2.2 Reagents: Acetic Acid Solvents: Methanol; Ph 7.3,5 °C3.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  24424-99-5 = 104-15-4
  反应条件:1.1 Reagents: Lithium Tert-Butoxide Solvents: Toluene1.2 Reagents: Hydr°Chloric Acid Solvents: Water; 2 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Tert-Butyl Methyl Ether,Water; Ph 12 - 131.4 Overnight,Rt; 2 H,60 °C2.1 Reagents: Sodium Hydroxide,Potassium Chloride Catalysts: Subtilisin Solvents: Acetone,Water; 91 H,Ph 8.1 - 8.3,35 - 37 °C2.2 Reagents: Hydr°Chloric Acid Solvents: Water; 75 H,Ph 2 - 3,Rt3.1 Solvents: Methanol; 0.25 H,25 - 35 °C; 2 H,50 °C3.2 Reagents: Acetic Acid Solvents: Methanol; Ph 7.3,5 °C4.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  623-33-6 = 104-15-4
  反应条件:1.1 Reagents: Triethylamine,Sodium Sulfate Solvents: Tert-Butyl Methyl Ether; 0.17 H,5 °C; 24 H,Rt2.1 Reagents: Lithium Tert-Butoxide Solvents: Toluene2.2 Reagents: Hydr°Chloric Acid Solvents: Water; 2 H,Rt2.3 Reagents: Sodium Hydroxide Solvents: Tert-Butyl Methyl Ether,Water; Ph 12 - 132.4 Overnight,Rt; 2 H,60 °C3.1 Reagents: Sodium Hydroxide,Potassium Chloride Catalysts: Subtilisin Solvents: Acetone,Water; 91 H,Ph 8.1 - 8.3,35 - 37 °C3.2 Reagents: Hydr°Chloric Acid Solvents: Water; 75 H,Ph 2 - 3,Rt4.1 Solvents: Methanol; 0.25 H,25 - 35 °C; 2 H,50 °C4.2 Reagents: Acetic Acid Solvents: Methanol; Ph 7.3,5 °C5.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  = 104-15-4 + 97984-62-8 [标题:Reaction Conditions
  标题:Synthesis Of Analogs Of K-582A,An Antibiotic Heptapeptide
  作者:Mihara,Hisakazu; Aoyagi,Haruhiko; Yonezawa,Hiroo; Kuromizu,Kenji; Izumiya,Nobuo
  参考文献:International Journal Of Peptide & Protein Research 日期:1985 卷标:25(6) 页码:640-7]
  
  = 104-15-4
  反应条件:1.1 Solvents: Acetonitrile,Tetrahydrofuran; 2 H,50 - 60 °C; 50 °C -> Reflux; 70 - 80 °C
  标题:Treatment Of Cystic Fibrosis Or The Symptoms Ass°Ciatedd With Cystic Fibrosis
  参考文献:United States]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Acetonitrile,Tetrahydrofuran; Rt -> 37 °C; 33 - 37 °C
  标题:Preparation Of N-[4-Chloro-2-Hydroxy-3-(Piperazine-1-Sulfonyl)Phenyl]-N'-(2-Chloro-3-Fluorophenyl)Urea For Treatment Of Cystic Fibrosis
  参考文献:World Intellectual Property Organization]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Il-8 Receptor Antagonist
  参考文献:World Intellectual Property Organization]
  
  104-15-4 + 80875-98-5 = 104-15-4
  反应条件:1.1 Solvents: Toluene; Rt -> 110 °C; 14 H,110 °C
  标题:Preparation Of Perindopril Tert-Butylamine Salt
  参考文献:China]
  
  104-15-4 + 80875-98-5 + 100-51-6 = 104-15-4
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene
  标题:Method For Synthesis Of (2S,3As,7As)-Perhydroindole-2-Carboxylic Acid And Esters As Intermediates In The Synthesis Of Perindopril
  参考文献:European Patent Organization]
  
  104-15-4 + 80875-98-5 + 100-51-6 = 104-15-4
  反应条件:1.1 Solvents: Toluene; 100 - 118 °C
  标题:Preparation Of Novel Crystalline Form Of Perindopril Erbumine Monohydrate
  参考文献:World Intellectual Property Organization]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Configuration And Preferential Solid-State Conformations Of Perindoprilat (S-9780). Comparison With The Crystal Structures Of Other Ace Inhibitors And Conclusions Related To Structure-Activity Relationships
  作者:Pascard,Claudine; Guilhem,Jean; Vincent,Michel; Remond,Georges; Portevin,Bernard; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:1991 卷标:34(2) 页码:663-9]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Preparation Of Perindopril Via Acylation Of Perhydroindolecarboxylate With N-[(Ethoxycarbonyl)Butyl]Alanine
  参考文献:European Patent Organization]
  
  = 104-15-4 [标题:Reaction Conditions
  标题:Racemate Separation Of Optically Active Bicyclic Imino-α-Carboxylic Acids
  参考文献:Federal Republic Of Germany]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Tetrahydrofuran; Rt
  标题:A Hydrophilic Coumarin-Based Polyester For Ambient-Temperature Initiator-Free 3D Printing: Chemistry,Rheology And Interface Formation
  作者:Govindarajan,Sudhanva R.; Jain,Tanmay; Choi,Jae-Won; Joy,Abraham; Isayeva,Irada; Et Al
  参考文献:Polymer 日期:2018 卷标:152 页码:9-17]
  
  = 104-15-4
  反应条件:1.1 Solvents: Toluene; 60 °C; 1 H,60 °C
  标题:Co-Initiated Hyperbranched-Polydendron Building Bl°Cks For The Direct Nanoprecipitation Of Dendron-Directed Patchy Particles With Heterogeneous Surface Functionality
  作者:Hern,F. Y.; Hill,A.; Owen,A.; Rannard,S. P.
  参考文献:Polymer Chemistry 日期:2018 卷标:9(14) 页码:1767-1771]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Toluene; 1 H,60 °C
  标题:Adhesion Properties Of Catechol-Based Biodegradable Amino Acid-Based Poly(Ester Urea) Copolymers Inspired From Mussel Proteins
  作者:Zhou,Jinjun; Defante,Adrian P.; Lin,Fei; Xu,Ying; Yu,Jiayi; Et Al
  参考文献:Biomacromolecules 日期:2015 卷标:16(1) 页码:266-274]
  
  104-15-4 = 104-15-4 [标题:Reaction Conditions
  标题:Multifunctional Polymer Nan°Carrier For Efficient Targeted Cellular And Subcellular Anticancer Drug Delivery
  作者:Babikova,Dimitrina; Kalinova,Radostina; Momekova,Denitsa; Ugrinova,Iva; Momekov,Georgi; Et Al
  参考文献:Acs Biomaterials Science & Engineering 日期:2019 卷标:5(5) 页码:2271-2283]
  
  104-15-4 = 104-15-4 [标题:Reaction Conditions
  标题:Reversible Phot°Curing Of Liquid Hexa-Anthracene Compounds For Adhesive Applications
  作者:Akiyama,Haruhisa; Okuyama,Yoko; Fukata,Tamaki; Kihara,Hideyuki
  参考文献:Journal Of Adhesion 日期:2018 卷标:94(10) 页码:799-813]
  
  104-15-4 = 104-15-4
  反应条件:1.1 Solvents: Toluene; Heated1.2 Solvents: Toluene; Heated; Rt
  标题:Uv-Cured Hyperbranched Polyester Polythiol(H20-Sh)-Epoxy Acrylate Networks: Preparation,Thermal And Mechanical Properties
  作者:Guan,Xiao-Xiao; Gan,Jian-Qun; Chen,Guo-Kang; Huang,Xiao-Mei; Lu,Man-Geng; Et Al
  参考文献:Journal Of Macromolecular Science 日期:2017 卷标:54(10) 页码:662-668]
  
  = 104-15-4
  反应条件:1.1 Solvents: Tetrahydrofuran; 1 H,Rt
  标题:Synthesis And Phot°Chemical Properties Of 3,6-Di-Tert-Butyl-9H-Carbazole Derivatives
  作者:Gruzdev,M. S.; Chervonova,U. V.; Venediktov,E. A.; Rozhkova,E. P.; Kolker,A. M.; Et Al
  参考文献:Russian Journal Of General Chemistry 日期:2015 卷标:85(6) 页码:1431-1439]
  
  = 104-15-4 + 88-20-0
  反应条件:1.1 Reagents: Sulfuric Acid (Silica Supported); 30 Min,80 °C
  标题:A Novel Method For Sulfonation Of Aromatic Rings With Silica Sulfuric Acid
  作者:Hajipour,Abdol R.; Et Al
  参考文献:Tetrahedron Letters 日期:2004 卷标:45(35) 页码:6607-6609]
  
  = 104-15-4 + 88-20-0
  反应条件:1.1 Reagents: Sulfur Trioxide; 58.5 °C
  标题:Study On The Sulfonation Of Toluene With So3 In Microreactor
  作者:Chen,Yanquan; Et Al
  参考文献:Huaxue Fanying Gongcheng Yu Gongyi 日期:2013 卷标:29(3) 页码:253-259]
  
  104-15-4 = 104-15-4 + 429658-95-7
  反应条件:1.1 Reagents: Hydr°Chloric Acid Solvents: Ethanol1.2 Reagents: Ammonium Hydroxide Solvents: Water
  标题:Identification,Synthesis,And Strategy For The Reduction Of Potential Impurities Observed In Dabigatran Etexilate Mesylate Pr°Cesses
  作者:Zheng,Yong-Yong; Et Al
  参考文献:Organic Pr°Cess Research & Development 日期:2014 卷标:18(6) 页码:744-750]
  
  = 104-15-4
  反应条件:1.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  24424-99-5 = 104-15-4
  反应条件:1.1 Reagents: Lithium Tert-Butoxide Solvents: Toluene1.2 Reagents: Hydr°Chloric Acid Solvents: Water; 2 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Tert-Butyl Methyl Ether,Water; Ph 12 - 131.4 Overnight,Rt; 2 H,60 °C2.1 Reagents: Sodium Hydroxide,Potassium Chloride Catalysts: Subtilisin Solvents: Acetone,Water; 91 H,Ph 8.1 - 8.3,35 - 37 °C2.2 Reagents: Hydr°Chloric Acid Solvents: Water; 75 H,Ph 2 - 3,Rt3.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  = 104-15-4
  反应条件:1.1 Solvents: Ethanol; 2 H,60 °C; 6 H,60 °C -> 25 °C; 18 H,Rt2.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; 0.75 H,24 °C; 22 H,20 °C3.1 Solvents: Methanol; 0.25 H,25 - 35 °C; 2 H,50 °C3.2 Reagents: Acetic Acid Solvents: Methanol; Ph 7.3,5 °C4.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879]
  
  = 104-15-4
  反应条件:1.1 Reagents: Lithium Tert-Butoxide Solvents: Toluene1.2 Reagents: Hydr°Chloric Acid Solvents: Water; 2 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Water2.1 Solvents: Ethanol; 2 H,60 °C; 6 H,60 °C -> 25 °C; 18 H,Rt3.1 Reagents: Sodium Hydroxide Solvents: Tetrahydrofuran,Water; 0.75 H,24 °C; 22 H,20 °C4.1 Solvents: Methanol; 0.25 H,25 - 35 °C; 2 H,50 °C4.2 Reagents: Acetic Acid Solvents: Methanol; Ph 7.3,5 °C5.1 Solvents: Methanol; 20 Min,Rt; 4 H,40 °C; Overnight,Rt
  标题:Synthesis Of (1R,2S)-1-Amino-2-Vinylcyclopropanecarboxylic Acid Vinyl-Acca) Derivatives: Key Intermediates For The Preparation Of Inhibitors Of The Hepatitis C Virus Ns3 Protease
  作者:Beaulieu,Pierre L.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(15) 页码:5869-5879

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