专利号:US-9067877-B2 优先权日:2011-06-22 标 题:Process for the production of 1,3,3-trimethyl-2-(3-methylpent-2-en-4-ynyl)cyclohex-1-ene 发明人:BONRATH WERNER; NETSCHER THOMAS; SCHÜTZ JAN; WÜSTENBERG BETTINA 权利人:BONRATH WERNER; NETSCHER THOMAS; SCHÜTZ JAN; WÜSTENBERG BETTINA; DSM IP ASSETS BV 摘要:The present invention relates to an improved process for the production of 1,3,3-trimethyl-2-(3-methylpent-2-en-4-ynyl)cyclohex-1-ene, highly enriched in the Z-isomer, and the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) the synthesis of vitamin A or β-carotene or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin.
专利号:US-2012063983-A1 优先权日:2010-09-10 标题:Method for Synthesis of Boron Nitride Nanopowder 发明人:DVALI NUGZAR VALERIANOVICH; TABATADZE JASHA MIHAILOVICH; FIGOVSKY OLEG LVOVICH 权利人:DVALI NUGZAR VALERIANOVICH; TABATADZE JASHA MIHAILOVICH; FIGOVSKY OLEG LVOVICH; POLYMATE LTD; MALAXIT LTD 摘要:A reaction is carried in a gaseous phase between ammonia (NH3) and boron trifluoride (BF3) in a cooled reactor under atmospheric pressure. A boron trifluoride-ammonia complex (NH3.BF3) obtained in this reaction is thermally decomposed at a temperature in the range of 125 to 300° C. into boron nitride and ammonium tetrafluoroborate in accordance with the following scheme: 125-300° C. 4NH3.BF3→BN+3NH4.BF4 BN is then separated from the mixture of BN with 3NH4.BF4 by combining the mixture with deionized water, forming a suspension, and separating the suspended BN nanoparticles by centrifugation.
专利号:US-11518726-B2 优先权日:2017-10-11 标题 :Synthesis of bicyclo[2.2.2]octane derivatives 发明人:HU YUE RACHEL; HEMBRE ROBERT THOMAS; TUSTIN GERALD CHARLES; LIU ZHUFANG; ADAMS STEVEN J 权利人:EASTMAN CHEM CO 摘要:Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst to afford an oxo-substituted bicyclo[2.2.2]octane species. This intermediate structure can then be further derivatized. The processes of this disclosure thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.
专利号:US-7683180-B2 优先权日:2001-04-16 标题 :Group 8 transition metal carbene complexes as enantionselective olefin metathesis catalysts 发明人:GRUBBS ROBERT H; WARD DONALD W; SEIDERS THOMAS J; GOLDBERG STEVEN D 权利人:CALIFORNIA INST OF TECHN 摘要:The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions, and for enantioselective reactions in particular. The synthesis of these complexes and details of their use as catalysts is also provided.
专利号:US-11174213-B2 优先权日:2018-10-12 标题:Effects of catalyst concentration and solid activator on nickel-mediated olefin/carbon dioxide coupling to acrylates 发明人:Iacono Pasquale; HLAVINKA MARK L 权利人:CHEVRON PHILLIPS CHEMICAL CO LP 摘要:This disclosure provides for routes of synthesis of acrylic acid and other α,β-unsaturated carboxylic acids and their salts, including catalytic methods. For example, there is provided a process for producing an α,β-unsaturated carboxylic acid or a salt thereof, the process comprising: (1) contacting in any order, a group 8-11 transition metal precursor, an olefin, carbon dioxide, a diluent, and a metal-treated chemically-modified solid oxide such as a sulfur oxoacid anion-modified solid oxide, a phosphorus oxoacid anion-modified solid oxide, or a halide ion-modified solid oxide, to provide a reaction mixture; and (2) applying reaction conditions to the reaction mixture suitable to produce the α,β-unsaturated carboxylic acid or the salt thereof. Methods of regenerating the metal-treated chemically-modified solid oxide are described.
专利号:WO-2022256660-A1 优先权日:2021-06-04 标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels 发明人:HARRISON CRISTIAN 权利人:VERTEX PHARMA 摘要:Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.