CAS: 147228-37-3; (R)-3-Amino-5-Phenylpentanoic Acid

相似化合物

218608-84-5 269398-87-0 218278-62-7

上下游产品

3-hydroxyamino-5-phenylpentanoic acid 3-phenyl-propionaldehyde malonic acid 5-phenyl-2(E)-pentenoic acid 3-(R)-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-5-phenylpentanoic acid

(3R)-5-Phenyl-3-(Tosylamino)Pentanoic Acid置于氢溴酸,Methyloxirane体系中,化学反应生成D-3-氨基-5-苯基戊酸.盐酸盐
参考文献:β-氨基酸,它们的α-羟基衍生物以及bestatin和microginin的n端组分的对映选择性合成
标题:β-氨基酸,它们的α-羟基衍生物以及bestatin和microginin的n端组分的对映选择性合成
摘要:通过甲苯磺酸化,酸酐形成和用nabh 4还原而得到的l-天冬氨酸被转化为(3S)-3-(甲苯磺酰基氨基)丁烷-4-醇化物(8;方案1).的tretment 8用乙醇三甲基碘硅烷,得到ñ-保护的脱氧碘β-高丝氨酸乙酯9.后者在连续的亲核置换过程中,用二烷基铜锂(10A-E),碱性水解(11A-E)和甲苯磺酰基的还原去除,产生了相应的4-取代的(3 R)-3-氨基丁酸12A.-E(ee> 99%).8的亲电羟基化(19;方案3),随后的碘酯化(21;方案4),以及在皂化和脱保护后,进行亲核烷基化和苯基化,得到一系列的4-取代的(2 S,3 R)-3-氨基-2-羟基丁酸24分别包括bestatin和microginin(de> 95%)的n端酸24E(= 3)和24F(= 4).
Doi:10.1002/hlca.19960790426

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2005009151-A1
优先权日:2003-07-10
标 题 :Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
发明人：CHASE MATTHEW; CLAYTON ROBERT; LANDIS BRYAN; BANERJEE AMIT
权利人:PHARMACIA CORP
摘要:The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:US-11091522-B2
优先权日:2018-07-23
标题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.