专利号:US-9458111-B2 优先权日:2010-07-29 标题:Process for the synthesis of substituted urea compounds 发明人:LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS 权利人:LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS; BIAL—PORTELA & CA S A 摘要:A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: n nthe process comprising the reaction of a carbamate of Formula (II′): Formula (I′):n n nwith a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.
专利号:US-8933227-B2 优先权日:2009-08-14 标题 :Selective synthesis of functionalized pyrimidines 发明人:LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN 权利人:LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN; BOEHRINGER INGELHEIM INT 摘要:The present invention relates to a process for making 2,4-differentiated 5-trifluoromethyl pyrimidines and 2-amino-5-trifluoromethyl-pyrimidine derivatives, which compounds are useful in the preparation of pharmacologically active compounds.
专利号:US-11787803-B2 优先权日:2017-09-15 标 题 :Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors 发明人:SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST ANGELA V; DOWNING JENNIFER R; ERICSSON ANNA 权利人:FORMA THERAPEUTICS INC 摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
专利号:US-2013123493-A1 优先权日:2010-07-29 标题 :Process for the synthesis of substituted urea compounds
专利号:US-2011190499-A1 优先权日:2009-08-14 标题 :Selective synthesis of functionalized pyrimidines
专利号:EP-2606035-B1 优先权日:2010-07-29 标题:Proces for the synthesis of substituted urea compounds