CAS: 17452-27-6; 3-Pyridylisothiocyanate

相似化合物

732245-99-7 18364-47-1 4318-78-9

上下游产品

Triethylammonium-N-pyrid-3-yl-dithi°Carbamate pyridin-3-ylamine thiophosgene phosgene N-[3]pyridyl-N'-(toluene-4-sulfonyl)-ureaN-[3]pyridyl-N'-(toluene-4-sulfonyl)-urea 1-(2,2-dimethyl-propyl)-3-pyridin-3-yl-thiourea 4-chloro-N-(2,2,2-trichloro-1-(((3-pyridinylamino)carbothioyl)amino)ethyl)benzamide

Triethylammonium-N-Pyrid-3-Yl-Dithiocarbamate置于sodium Persulfate,Potassium Carbonate体系中,用 水 用作溶剂,化学反应 1.0H,以72%的收率获得吡啶-3-异硫氰酸酯
参考文献:Na 2 S 2 O 8介导的水中伯胺高效合成异硫氰酸酯
标题:Na 2 S 2 O 8介导的水中伯胺高效合成异硫氰酸酯
摘要:我们已经开发了两种绿色,实用且有效的方法,包括一锅法,可通过胺和二硫化碳通过胺合成异硫氰酸酯.用过硫酸钠脱硫.使用水作用作溶剂.为了使异硫氰酸酯具有非常好的化学选择性,必须具备碱性条件.通过两种方法,结构令人满意的直链和支链烷基胺和芳基胺很容易以令人满意的收率转化为异硫氰酸酯.卤素,苄基ch键,甲硫基,硝基,酯,烯基,富电子或不足的(杂)芳基,乙炔基,甚至酚和醇羟基均被很好地耐受.在水中一锅法也可用于从手性胺制备手性异硫氰酸酯,以及用游离氨基修饰生物活性结构.在大规模制备中,开发了独立于柱色谱法的简单实用的纯化方法.
Doi:10.1039/c8Gc02261E

专利信息

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:US-8017323-B2
优先权日:2003-03-26
标 题 :Free reactant use in nucleic acid-templated synthesis
发明人：LIU DAVID R; SAKURAI KAORI
权利人:HARVARD COLLEGE
摘要:The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates attached to an oligonucleotide that can be used to identify the reaction intermediates and/or the resulting reaction products. The reaction intermediates then are reacted with free reactants (for example, reactants that are difficult or impractical to couple to an oligonucleotide) to produce a reaction product. This approach expands the scope of reagents useful in nucleic acid-templated syntheses to reagents that do not need to be or cannot be tethered to an oligonucleotide. The reagents, however, still permit the synthesis of reaction products attached to oligonucleotides that can be used to identify the reaction products.

专利号:US-7579459-B2
优先权日:2005-12-12
标 题 :Activator bound solid supports for nucleic acid synthesis via the phosphoramidite approach
发明人：NGO NAM Q; JAQUINOD LAURENT
权利人:NGO NAM Q; JAQUINOD LAURENT
摘要:The present invention relates to improved methods for the preparation of nucleic acids. More particularly, conventional solid supports used for nucleic acid synthesis are derivatized with activators having pKas within the 4 to 7 range. Preferentially, CPG-based solid supports are reacted with trialkoxysilanes containing an activator moiety such as pyridine. During each deblocking step of the nucleic acid synthesis cycle, bound pyridiniums are generated, yielding a weak acidic medium spreads throughout the solid support. The bound activators efficiently activate the phosphoramidite reagents towards coupling with 5′-hydroxynucleosides bound to the solid supports, thus eliminating or supplementing external deliveries of activator during the coupling steps.

专利号:US-2003009034-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人：WISHART NEIL; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:US-2003109714-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人：WISHART NEIL; RUDOLPH ALENA; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:US-2013225821-A1
优先权日:2007-03-27
标 题:Synthesis of thiohydantoins