CAS: 3619-22-5; P-Toluic Hydrazide

该化合物是多种药物和精美化学品合成中广泛使用的多种有机化合物,其纯度和稳定性很高,适合复杂反应.其独特的结构特征使得能够高效反应,提高产量和选择性.该化合物也因其与一系列合成方法相容而闻名,有助于其在化学研发中的普及.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号94-08-6 对甲基苯甲酸乙酯 | CAS号99-94-5 对甲基苯甲酸 | CAS号36930-95-7 2,2,2-trichloro... | CAS号874-60-2 对甲基苯甲酰氯 | CAS号13222-85-0 对甲苯甲酸酐 | CAS号820209-69-6 tert-butyl N-[(... | CAS号15023-67-3 (4-nitrophenyl)... | CAS号106733-81-7 (1E,3E)-2-methy... | CAS号106710-49-0 3-[2-(4-methylb... | CAS号31130-15-1 5-(4-甲基苯基)-1,3,... | CAS号141079-06-3 3-[(4-chloro-3-... | CAS号141078-91-3 3,4-bis(4-methy... | CAS号141078-99-1 3-[(4-methylphe... | CAS号199938-21-1 N'-(氯乙酰基)-4-甲基苯甲酰肼 | CAS号22693-32-9 4-methylbenzoyl... | CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号99-94-5 对甲基苯甲酸

合成工艺路线路线简述

    对甲基苯甲酸乙酯置于一水合肼体系中,化学反应 2.0H,反应生成对甲苯甲酰肼
    参考文献:3-取代(6-[(E)-2-(1-苯并呋喃-2-基)乙烯基][1,2,4]三唑并[3,4-B][1,3,4]噻二唑的合成
    标题:3-取代(6-[(E)-2-(1-苯并呋喃-2-基)乙烯基][1,2,4]三唑并[3,4-B][1,3,4]噻二唑的合成
    摘要:研发了 (2E)-3-(1-Benzofuran-2-yl)-2-Propenoic Acid 与 4-Amino-5-R-1,2,4-Triazole-3-Thioles 的反应.已确定 6-[(E)-2-(1-Benzofuran-2-yl)Ethenyl][1,2,4]Triazolo[3,4-B][1,3,4] 噻二唑是杂环化的结果.
    Doi:10.1080/10426500701557310

    海关参考信息

    专利信息


    专利号:US-9085550-B2
    优先权日:2005-01-21
    标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
    发明人:FORMAN BARRY; YU DONNA
    权利人:FORMAN BARRY; YU DONNA; HOPE CITY
    摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

    专利号:US-6271391-B1
    优先权日:1998-03-13
    标题 :Hydrazide fixed to a resin and derivatives thereof, and a method for synthesizing pyrazolones in solid phase
    发明人:KOBAYASHI SHU; OYAMADA HIDEKAZU
    权利人:JAPAN SCIENCE & TECH CORP
    摘要:Hydrazide fixed to a resin represented by the following formula: n n n P—Q—CO—NH—NH 2   (I) n n n where P represents a main chain of a resin polymer and Q represents a hydrocarbon side chain optionally having a substituent which may be bonded via a heteroatom, and a hydrazone derived therefrom and fixed to a resin n n n P—Q—CO—NH—Nâ•?CH—R 1   (II) n n n are provided, and solid phase synthesis of pyrazolone is conducted using the same, thereby enabling synthesis of pyrazolones by the application of the Mannich type reaction based on the solid phase synthesis and efficient construction of libraries for various kinds of them.

    专利号:US-8981092-B2
    优先权日:2008-09-19
    标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
    发明人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
    权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
    摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

    专利号:US-2006189825-A1
    优先权日:2005-01-21
    标题:Ligands for estrogen related receptors and methods for synthesis of said ligands

    专利号:US-2022325053-A1
    优先权日:2019-08-13
    标题:Method for the synthesis of a two-dimensional or quasi-two-dimensional polymer film, the two-dimensional or quasi-two-dimensional polymer film and the use

    专利号:US-2013131340-A1
    优先权日:2005-01-21
    标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
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    合成参考文献


    参考文献:10.1107/s160053681101035x|10.1107/s1600536811010361
    摘要:Liu SY, Sun SS, Zheng TT, Zheng XL, Zhao XF, Li XF. (E)-N'-[(2-Hy-droxy-1-naphthalen-1-yl)methyl-idene]-3-methyl-benzohydrazide. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o965.
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