CAS: 4857-04-9; 2-(Chloromethyl)Benzimidazole

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CAS号79-11-8 氯乙酸 | CAS号95-54-5 邻苯二胺(OPD) | CAS号105-39-5 氯乙酸乙酯 | CAS号79-04-9 氯乙酰氯 | CAS号36743-66-5 2-氯-1-乙氧基乙胺 | CAS号615-28-1 邻苯二胺盐酸盐 | CAS号4856-97-7 2-羟甲基苯并咪唑 | CAS号442-52-4 克立咪唑 | CAS号4856-97-7 2-羟甲基苯并咪唑 | CAS号5805-57-2 (1H-苯并咪唑-2-亚甲基)胺 | CAS号4760-35-4 2-(氯甲基)-1-甲基-1H-苯并咪唑 | CAS号21094-70-2 2-苯磺酰基甲基-1H-苯并咪唑 | CAS号19809-02-0 1-[2-(chloromet... | CAS号19276-01-8 4-(1H-苯并[d]咪唑-2...

邻苯二胺置于盐酸,氯化亚砜体系中,用 水 作为反应溶剂,化学反应 6.0H,反应生成 2-氯甲基苯并咪唑
参考文献:选定的苯并咪唑衍生物作为潜在抗菌剂的合成与评价.
标题:选定的苯并咪唑衍生物作为潜在抗菌剂的合成与评价.
摘要:合成了53个苯并咪唑衍生物的文库,它们在1,2和5位具有取代基,并针对一系列与医学相关的细菌和真菌参考菌株进行了筛选.sar分析最有前景的结果表明,化合物的抗菌活性取决于与双环杂环相连的取代基.特别是,某些化合物对两种耐甲氧西林的金黄色葡萄球菌(mrsa)菌株表现出抗菌活性,其最低抑制浓度(mic)与广泛使用的环丙沙星药物相当.这些化合物具有一些共同特征.三个具有5-卤素取代基;两个是(S)-2-乙胺苯并咪唑的衍生物;其他是一种2-(氯甲基)-1H-苯并[d]咪唑和(1H-苯并[d]咪唑-2-基)甲硫醇的衍生物.抗真菌筛选的结果也非常有趣:23种化合物对选定的真菌菌株显示出有效的杀真菌活性.它们的mic值显示出比两性霉素b相同或更高的效力.5-卤代苯并咪唑衍生物被认为是有前途的广谱抗微生物候选物,值得进一步研究以用于潜在的治疗应用.
DOI:10.3390/molecules200815206

专利信息

专利号:US-RE31624-E
优先权日:1979-11-26
标 题 :Method of treating inflammation
摘要:A method of treating inflammation and inhibiting prostaglandin synthesis employing substituted 2-(arylmethoxy)phenol compounds.

专利号:US-7332605-B2
优先权日:2004-03-15
标题 :Process for the synthesis of CXCR4 antagonist
发明人：CRAWFORD JASON B; CHEN GANG; GAUTHIER DAVID; SKERLJ RENATO; BAIRD IAN R; WILSON TREVOR R
权利人:ANORMED INC
摘要:This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor. In one embodiment, the process comprises: a) reacting a 5,6,7,8-tetrahydroquinolinylamine and an alkyl aldehyde bearing a phthalimide or a di-tertiary-butoxycarbonyl (di-BOC) protecting group to form an imine; b) reducing the imine to form a secondary amine; c) reacting the secondary amine with a haloalkyl substituted heterocyclic compound, to form a phthalimido-protected or di-tert-butoxycarbonyl protected tertiary amine; and d) hydrolyzing the protected amine to obtain a compound having Formula I′

专利号:CA-2558389-C
优先权日:2004-03-15
标 题 :Process for the synthesis of a cxcr4 antagonist

专利号:AU-2005224079-A1
优先权日:2004-03-15
标题 :Process for the synthesis of a CXCR4 antagonist

专利号:US-2005209277-A1
优先权日:2004-03-15
标 题 :Process for the synthesis of CXCR4 antagonist

专利号:CN-107759604-A
优先权日:2017-10-11
标题 :A kind of method that catalyzes the synthesis of benzimidazoquinoxaline derivatives under microwave radiation