CAS: 595-37-9; 2,2-Dimethylbutanoic Acid

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CAS号513-35-9 2-甲基-2-丁烯 | CAS号201230-82-2 carbon monoxide | CAS号54509-73-8 ethene | CAS号79-31-2 异丁酸 | CAS号75-85-4 叔戊醇 | CAS号1955-45-9 Pivalolactone. | CAS号75-16-1 甲基溴化镁 | CAS号996-30-5 异丁酸钠 | CAS号503-74-2 异戊酸 | CAS号109-67-1 1-戊烯 | CAS号29138-64-5 2,2-DIMETHYLBUT... | CAS号79902-63-9 辛伐他汀，斯伐他汀 | CAS号5856-77-9 2,2-二甲基丁酰氯 | CAS号100475-32-9 2,2-dimethyl-1-... | CAS号15501-38-9 N-(2-methylbuta... | CAS号1612-71-1 2-is°Cyanato-2-... | CAS号1185-33-7 2,2-二甲基丁醇 | CAS号124-38-9 二氧化碳 | CAS号78-84-2 异丁醛 | CAS号67-64-1 丙酮

2,2-二甲基-1-丁醇置于铜体系中,化学反应生成 2,2-二甲基丁酸
参考文献:Conant; Webb; Mendum,Journal Of The American Chemical Society,1929,Vol. 51,P. 1253
标题:Conant; Webb; Mendum,Journal Of The American Chemical Society,1929,Vol. 51,P. 1253

专利信息

专利号:US-4288608-A
优先权日:1978-06-01
标题:Synthesis of anthracyclines
发明人：JOHNSON FRANCIS; KIM KYOUNG S
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivitive adriamycin.

专利号:WO-2012101052-A1
优先权日:2011-01-25
标 题:Cleaning dry residues of the direct synthesis of alkylchlorosilanes
发明人：ALBER ANNE; KUNERT JAN; ZIPP ALEXANDER; EBERLE HANS-JUERGEN
权利人:WACKER CHEMIE AG; ALBER ANNE; KUNERT JAN; ZIPP ALEXANDER; EBERLE HANS-JUERGEN
摘要:The invention relates to a method for cleaning dry residues of the direct synthesis of alkylchlorosilanes by treating the residues with an organic solvent.

专利号:US-2009197311-A1
优先权日:2006-06-20
标题:Method for the production of simvastatin
发明人：BERG MARCO ALEXANDER VAN DEN; HANS MARCUS; STREEKSTRA HUGO
权利人:BERG MARCO ALEXANDER VAN DEN; HANS MARCUS; STREEKSTRA HUGO
摘要:The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process.

专利号:US-2009081801-A1
优先权日:2007-08-15
标题:Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
发明人：KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
权利人:KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
摘要:The present invention also relates to a novel impurity, (6-{2-[2-(6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetylamino]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetic acid tert-butyl ester, the compound of formula IV, having the following structure: n n n n n n n n n n The present invention also provides methods of preparing the compound of formula IV as well as methods of using the compound of formula IV as a reference marker and a reference standard. n The present invention also provides an improved process for preparing (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester, the compound of formula I, said process comprising the step of condensing 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butanamide, the compound of formula III, with (4R,Cis)-1,1-dimethylethyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, the compound of formula II, in the presence of a catalytic amount of an acid in the presence of a solvent system, preferably a binary solvent system, to obtain the desired compound (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester.

专利号:US-5256811-A
优先权日:1991-05-23
标 题:Certain intermediates for the preparation of neuinic acid derivatives
发明人：TODD RICHARD S; REEVE MAXWELL
权利人:BRITISH BIO TECHNOLOGY
摘要:compounds of formula I ##STR1## wherein R 1 represents a C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl(C 1-8 )alkyl, C 1-8 hydroxyalkyl, C 1-8 alkylthio, phenyl or substituted phenyl; n R 3 represents a C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, CO2(C 1-8 )alkyl, CO 2 (C 2-8 ) alkenyl, C 1-8 alkylthio, (C 1-2 )alkyl CO 2 (C 1-8 ) alkyl or C 1-8 aldehydroalkyl where the aldehyde function is protected by a suitable protecting group (for example, an acetal such as a dimethyl acetal); n R 4 represents a hydrogen atom, C 1-8 alkyl or C 2-8 alkenyl; n Z represents a group (CH 2 ) n or a branched alkyl chain; n n is 1 to 8; n and each of a, b and c is independently a single or a double bond; n can be prepared relatively easily and in good xxx at room temperature by reacting a compound of general formula II ##STR2## wherein R 2 , R 3 , R 4 , Z, a, b and c are as define din general formula I; with a compound of general formula III n n CHI.sub.2 R.sup.1 (III) n n wherein R 1 is as defined in general formula I; n in the presence of metal ions such as chromium (II) ions. The sever conditions of the Wittig reaction can therefore be avoided. n Compounds of formula I are useful intermediates in the synthesis of mevinic acids, which are potent inhibitors of HMG-CoA reductase and which are useful in the treatment of hypocholesterolaemia an hyperlipidaemia.

专利号:US-5223415-A
优先权日:1990-10-15
标题 :Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
发明人：CONDER MICHAEL J; CIANCIOSI STEVEN J; COVER WILLIAM H; DABORA REBECCA L; PISK ERIC T; STIEBER ROBERT W; TEHLEWITZ BOGDAN; TEWALT GREGORY L
权利人:MERCK & CO INC
摘要:Biosynthetic production of 7-[1',2',6',-7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy -1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid, 'triol acid', is accomplished by enzymatic hydrolysis of lovastatin acid or a salt thereof, by treating it with Clonostachys compactiuscula ATCC 38009 or ATCC 74178, or mutants thereof, or a cell-free extract derived therefrom, or a hydrolase derived therefrom. The triol acid and its lactone form are both inhibitors of HMG-CoA reductase and thus useful as anti-hypercholesterolemic agents, and may also serve as intermediates for preparation of other HMG-CoA reductase inhibitors. Also, in the synthesis of simvastatin by direct methylation of lovastatin, selective hydrolysis of residual lovastatin salt by treatment with Clonostachys compactiuscula ATCC 38009 or ATCC 74178 or mutants thereof or a cell-free extract derived therefrom, or a hydrolase derived therefrom yields the 'triol' salt which can be easily separated from simvastatin.