CAS: 85-27-8; 4-(1-Phenylethyl)Benzene-1,3-Diol

上下游产品

CAS号98-85-1 苏合香醇 | CAS号151-10-0 间苯二甲醚 | CAS号150-19-6 3-甲氧基苯酚 | CAS号108-46-3 间苯二酚 | CAS号292638-84-7 phenylene-ethylene | CAS号1445-91-6 (S)-(-)-1-苯基乙醇

间苯二酚 以90%的收率获得产物
参考文献:Yusupov A.; Mamadzhanov A.; Abdurasuleva A. R.,Redkollegiya Uzb. Xim. Zh. An Uzssr,Tashkent,1978,8S. Bibliogr. 5 Nazv+
标题:Yusupov A.; Mamadzhanov A.; Abdurasuleva A. R.,Redkollegiya Uzb. Xim. Zh. An Uzssr,Tashkent,1978,8S. Bibliogr. 5 Nazv+

专利信息

专利号:EP-2746253-A1
优先权日:2012-12-21
标 题 :Novel compounds with skin lightening properties
发明人：BAXENDALE IAN RICHARD; GINGER REBECCA SUSAN; GLEN ROBERT CHARLES; GREEN MARTIN RICHARD; RIVA ELENA; SCHNETKAMP PAUL PETRUS MARIUS; SZERENCSEI ROBERT TIMOTHY; ZMUIDINAVICIUS DONATAS
权利人:UNILEVER PLC
摘要:This invention relates to novel compounds with skin lightening properties based on an aromatic hydrazine carboxyimidoamide structure, topical skin lightening compositions comprising the same and a method of skin lightening using the said compositions. In particular, the skin lightening benefit is selected from any one of the group consisting of treating melasma, treating post-inflammatory hyperpigmentation, treating age spots, treating dark spots and treating uneven skin tone. n Desired skin colour is a major unmet consumer need around the world and especially in Asia. Consumers particularly desire even skin colour, absence of age spots (solar lentigines), absence of hyperpigmentation and lighter overall skin tone. One solution is to use biological actives that reduce the activity of melanocyte cells in skin. These cells, present in the basal layer of the epidermis, make the dark coloured pigment melanin and export it, in small export vesicles called melanosomes, to the neighbouring keratinocytes. It is well described in the literature that compounds which reduce melanin synthesis when topically applied to the skin will reduce skin darkness over time and can generate a more even skin tone. n Tyrosinase is a very popular target for the regulation of melanocyte pigment production. However effective inhibitors of tyrosinase are bedevilled by safety issues causing, for example, melanocyte cell death, permanent depigmentation, irritation and allergic reactions. Often effective inhibitors kill melanocytes (for example hydroquinone) or cause sensitisation reactions. There is therefore a great need for safe and effective inhibitors of skin pigment production that work through an alternative safe mechanism. n The inventors have observed that selected compounds of the same generic structure inhibit the production of soluble melanin by B16 mouse melanoma cells without cell toxicity.

专利号:US-2016243015-A1
优先权日:2013-10-25
标题 :Skin lightening composition
发明人：GREEN MARTIN RICHARD; GINGER REBECCA SUSAN; GLEN ROBERT CHARLES
权利人:CONOPCO INC DBA UNILEVER
摘要:Desired skin colour is a major unmet consumer need around the world and especially in Asia. Consumers particularly desire even skin colour, absence of age spots (solar lentigines), absence of hyperpigmentation and lighter overall skin tone. One solution is to use biological actives that reduce the activity of melanocyte cells in skin. These cells, present in the basal layer of the epidermis, make the dark coloured pigment melanin and export it, in small export vesicles called melanosomes, to the neighbouring keratinocytes. It is well described in the literature that compounds which reduce melanin synthesis when topically applied to the skin will reduce skin darkness over time and can generate a more even skin tone. Tyrosinase is a very popular target for the regulation of melanocyte pigment production. However effective inhibitors of tyrosinase are bedevilled by safety issues causing, for example, melanocyte cell death, permanent depigmentation, irritation and allergic reactions. Often effective inhibitors kill melanocytes (for example hydroquinone) or cause sensitisation reactions. There is therefore a great need for safe and effective inhibitors of skin pigment production that work through an alternative safe mechanism. The inventors have observed that selected compounds of the same generic structure: or a salt thereof; wherein R 1 , R 2 , R 3 , R 4 and R 5 may be independently selected from the group consisting of —H, -halide, and methyl, ethyl, propyl, iso-propyl, butyl, and t-butyl moieties, inhibit melanin production in Melanodermsâ„¢.

专利号:US-2010093823-A1
优先权日:2008-04-30
标 题 :Steroidal compounds as melanogenesis modifiers and uses thereof
发明人：ORLOW SETH J; KOMATSU LI NI
权利人:ORLOW SETH J; KOMATSU LI NI
摘要:A method for the identification of compounds) that control melanin synthesis (melanogenesis), and the preparation and use of such compounds, and compositions and formulations thereof to modify (e.g., inhibit) melanin production are disclosed. A representative compound of the invention is defined by formula I: n n n n n n n n n n The compounds may be prepared as pharmaceutical and cosmetic compositions, and in one embodiment, may be prepared in combination with each other, and with other melanogenesis inhibiting formulations. The compounds, compositions and formulations of the invention may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.

专利号:CN-115612114-A
优先权日:2021-07-14
标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis

专利号:US-11759412-B2
优先权日:2016-12-21
标题 :Personal care compositions with glutathione precursor comprising 4-substituted resorcinols and amino acids
发明人：GUELAKIS MARIAN PEREIRA; LEE JIANMING; ROSA JOSE GUILLERMO; MADISON STEPHEN ALAN; MI TINGYAN; DAMODARAN ANITA; KUMARI ANNU; HUANG NAN; HARICHIAN BIJAN
权利人:CONOPCO INC
摘要:Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.