CAS: 10403-47-1; 2-Bromo-5-Nitroaniline

相似化合物

6264-69-3 53324-38-2 35757-20-1

上下游产品

2,4-dinitrobromobenzene 3-nitro-aniline 2-bromoaniline sulfuric acid N-(2-bromo-5-nitrophenyl)formamide 2-amino-4-nitrobenzenethiol 2,4-dibromo-5-nitroaniline 5,5'-dinitro-2,2'-sulfanediyl-di-aniline

1-溴-2,4-二硝基苯置于sodium Sulfide,水体系中,用 甲醇,Phosphate Buffer 用作溶剂,化学反应 12.0H,以7%的收率获得2-溴-5-硝基苯胺
参考文献:Factors Controlling Regioselectivity In The Reduction Of Polynitroaromatics In Aqueous Solution
标题:Factors Controlling Regioselectivity In The Reduction Of Polynitroaromatics In Aqueous Solution
摘要:Regioselectivities In The Bisulfide Reduction Of 10 Polynitroaromatics (Pnas) To Monoamine Products Have Been Determined; Four Of These Compounds Have Also Been Reduced By Anoxic Sediments In Heterogeneous Aqueous Solution,And The Same Regioselectivities Are Observed. Analyses Of Austin Model 1-Solvation Model 2 Electrostatic Potential Surfaces For The Radical Anions Of These Polynitroaromatic Compounds Provides A Reliable Method Of Predicting The Regioselectivity Of Their Reduction. In Particular,At Their Minimum-Energy Geometries In Aqueous Solution,It Is The More Negative Nitro Group That Is Selectively Reduced. This Is Consistent With A Mechanism Where Regioselection occurs Upon Kinetic Protonation At The Site Of Maximum Negative Charge In The Radical Anion Formed After The First Electron Transfer To The Neutral Pna. Inclusion Of Solvation Effects Is Critical In Order To Confidently Predict The Electrostatic Preference For The Reduction Of One Nitro Group Over The Others. Sterically Uncongested Nitroaromatic Radical Anions Have Gas-Phase Geometries In Which The Nitro Group Is Coplanar With The Aromatic Ring. However,Ortho Substituents And Solvation Effects Both Oppose This Tendency And Can Lead To Nitro Groups That Are Rotated Out Of The Ring Plane And Pyramidalized.
Doi:10.1021/es960004X

专利信息

专利号:EP-3070087-B1
优先权日:2011-08-05
标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:EP-3070087-A1
优先权日:2011-08-05
标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:CN-107915693-A
优先权日:2017-12-07
标 题 :A kind of method for the catalytic synthesis of 2-aminobenzothiazole derivatives of N,N-dimethylaminothioformyl chloride under microwave radiation

专利号:ES-2733096-T3
优先权日:2011-08-05
标题:Intermediaries for the synthesis of cyclic P1 linkers as XIA factor inhibitors

专利号:RU-2077535-C1
优先权日:1991-09-18
标 题 :Derivatives of benzanilide, method of their synthesis and pharmaceutical composition exhibiting antagonism to 5-ht1 receptors

专利号:US-9096624-B2
优先权日:2009-06-01
标 题:Amino pyrimidine anticancer compounds
发明人：CREW ANDREW P; SHERMAN DAN; APPARI RAMA DEVI; CHEN XIN; CHILUKURI RAMESH; DONG HANQING; FERRARO CATERINA; FOREMAN KENNETH; GUPTA RAMESH C; LI AN-HU; STOLZ KATHRYN M; VOLK BRIAN; ZAHLER ROBERT
权利人:OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.