CAS: 178813-78-0; 2,6-Dichloro-3-Fluorobenzoic Acid

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2',6'-dichloro-3'-fluoroacetophenone ((S)-1-{5-bromo-3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester ((S)-1-{5-bromo-3-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester 6-[6-amino-5-[(2,6-dichloro-3-fluorophenyl)methoxy]-3-pyridyl]-1'-methylspiro[indoline-3,4'-piperidine]-2-one 3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-5-(1-methyl-1H-imidazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

2,6-二氯-3-氟苯乙酮置于sodium Hypochlorite体系中,用84%的收率获得2,6-二氯-3-氟苯甲酸
参考文献:一种2,6-二氯-3-氟苯腈的合成方法
标题:一种2,6-二氯-3-氟苯腈的合成方法
摘要:本发明提供了一种2,6‑二氯‑3‑氟苯腈的合成方法,属于农药,医药中间体制备领域.它解决了现有合成2,6‑二氯‑3‑氟苯腈的方法收率低等问题,一种2,6‑二氯‑3‑氟苯腈的合成方法,其特征在于,包括如下步骤:So1:在氧化剂的存在下,2,6‑二氯‑3‑氟苯乙酮侧链氧化得到2,6‑二氯‑3‑氟苯甲酸;So2:2,6‑二氯‑3‑氟苯甲酸溶于溶剂后,通入氨气,得到2,6‑二氯‑3‑氟苯甲酰胺;So3:在脱水剂和引发剂的存在下,将2,6‑二氯‑3‑氟苯甲酰胺脱水得到2,6‑二氯‑3‑氟苯腈.本发明具有反应条件温和,收率高等优点.

专利信息

专利号:US-2013072495-A1
优先权日:2010-05-14
标 题 :Fused bicyclic kinase inhibitors
发明人：LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G
权利人:LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as but not limited to tumors driven at least in part by at least one of RON, MET, IR, IGF-1R, or ALK. This Abstract is not limiting of the invention.

专利号:US-2014088114-A1
优先权日:2011-05-16
标 题:Fused bicyclic kinase inhibitors
发明人：JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING
权利人:JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula (I), pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of MET, RON, ALK, IR, or IGF-1R. This Abstract is not limiting of the invention.

专利号:US-8592448-B2
优先权日:2008-11-20
标题:Substituted pyrrolo[2,3-b]-pyridines and -pyrazines
发明人：CHEN XIN; JIN MELZHONG; KLEINBERG ANDREW; LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; WANG JING
权利人:CHEN XIN; JIN MELZHONG; KLEINBERG ANDREW; LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: (I) pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by Ron and/or Met.

专利号:US-8445510-B2
优先权日:2010-05-14
标题 :Fused bicyclic kinase inhibitors
发明人：MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING
权利人:MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.