CAS: 19652-32-5; 3-Bromo-5-Chloro-2-Hydroxybenzaldehyde

上下游产品

CAS号635-93-8 5-氯水杨醛 | CAS号188813-16-3 8-bromo-6-chlor... | CAS号25299-26-7 3-溴-5-氯-2-(甲基氧基)苯甲醛 | CAS号116795-47-2 3-溴-5-氯-2-羟基苄醇 | CAS号825648-25-7 [2-bromo-4-chlo... | CAS号4068-58-0 3-溴-5-氯水杨酸

5-氯代水杨醛置于n-溴代丁二酰亚胺(Nbs)体系中,用 氯仿 用作溶剂,以44.4%的收率获得3-溴-5-氯水杨醛
参考文献:Preparation Of 2-,3-,4-And 7-(2-Alkylcarbamoyl-1-Alkylvinyl)Benzo[b]Furans And Their Blt1And/or Blt2Inhibitory Activities
标题:Preparation Of 2-,3-,4-And 7-(2-Alkylcarbamoyl-1-Alkylvinyl)Benzo[b]Furans And Their Blt1And/or Blt2Inhibitory Activities
摘要:设计了几种2-烷基氨基甲酰基-1-烷基乙烯基苯并[b]呋喃,旨在寻找选择性的白三烯b4(ltb4)受体拮抗剂.合成了在3-位具有取代基的2-(2-烷基氨基甲酰基-1-烷基乙烯基)苯并[b]呋喃,在3-位具有取代基的4-(2-烷基氨基甲酰基-1-甲基乙烯基)苯并[b]呋喃,7-(2-烷基氨基甲酰基-1-甲基乙烯基)苯并[b]呋喃和3-(2-烷基氨基甲酰基-1-烷基乙烯基)苯并[b]呋喃,并评估了它们对ltb4受体(blt1和blt2)的抑制活性.(E)-3-氨基-4-[2-[2-(3,4-二甲氧基苯基)乙基氨基甲酰基]-1-甲基乙烯基]苯并[b]呋喃((E)-17C)显示出对blt2具有强效且选择性的抑制活性.另一方面,(E)-7-(2-二乙基氨基甲酰基-1-甲基乙烯基)苯并[b]呋喃((E)-27A)对blt1和blt2均显示出强效的抑制活性.
Doi:10.1039/b710935K

专利信息

专利号:US-6414180-B1
优先权日:1998-03-04
标 题:Synthesis of chiral β-amino acids
发明人：COLSON PIERRE-JEAN; AWASTHI ALOK K; NAGARAJAN SRINIVASAN R
权利人:SEARLE & CO
摘要:The invention herein is directed to a process for the preparation of chiral beta-amino acids and esters of the formulawherein X and Y are the same or different halo groups, R2 is H or lower alkyl and isomers and pharmaceutically acceptable salts thereof.

专利号:US-9371334-B2
优先权日:2010-09-22
标题:Synthesis of substituted salicylaldehyde derivatives
发明人：FARMER JAY J; JOB GABRIEL E
权利人:NOVOMER INC
摘要:Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-10040800-B2
优先权日:2010-09-22
标 题:Synthesis of substituted salicylaldehyde derivatives

专利号:US-2015011761-A1
优先权日:2010-09-22
标题 :Synthesis of substituted salicylaldehyde derivatives

专利号:WO-2012040454-A2
优先权日:2010-09-22
标 题:Synthesis of substituted salicylaldehyde derivatives