CAS: 217300-17-9; (Triisopropylsiloxy)Methyl Chloride

相似化合物

122420-34-2 145383-93-3 162827-30-7

上下游产品

三异丙基硅烷醇 Triisopropylsilanol 17877-23-5
((Ethylthio)Methoxy)Triisopropylsilane 253586-28-6

((Ethylthio)Methoxy)Triisopropylsilane置于磺酰氯体系中,用 二氯甲烷 用作溶剂,化学反应 22.57H,以76%的收率获得(异丙氧基硅)氯甲烷
参考文献:通过转移氢化烯丙基化,巴豆酰化和炔丙基化全合成 Leiodermatolide A:超越离散烯丙基或烯丙基金属试剂的聚酮化合物构建
标题:通过转移氢化烯丙基化,巴豆酰化和炔丙基化全合成 Leiodermatolide A:超越离散烯丙基或烯丙基金属试剂的聚酮化合物构建
摘要:Leiodermatolide A 的全合成分 13 个步骤 (Lls) 完成.传统上依赖于预金属化试剂(烯丙基化,巴豆酰化和炔丙基化)的三种羰基加成的转移氢化变体在一个全合成中一起部署.
Doi:10.1021/jacs.1C06062

专利信息

专利号:US-2025236633-A1
优先权日:2022-03-28
标 题:Synthesis of isomerically pure polyol-based phosphoramidites
发明人：BANASIK BRENT; DIAZ CORRAL JULIAN ANDRES; JACOBS AARON; JUD LUKAS; KUCHELMEISTER HANNES; NBAVI MELUD; PFAFFENEDER TONI; SIMONYIOVA SONA; TABONE JOHN C; THUER WILMA
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.

专利号:WO-2014148928-A1
优先权日:2013-03-21
标 题:Method for incorporating protecting acetal and acetal ester groups, and its application for the protection of hydroxyl function
发明人：MARKIEWICZ WOJCIECH; TOÅš-MARCINIAK AGNIESZKA; CHMIELEWSKI MARCIN
权利人:INST CHEMII BIOORG POLSKIEJ AKADEMII NAUK
摘要:The present invention is the method for incorporation of acetal and acetal ester groups for protection of hydroxyl function. The method is applied in particular in the processes of RNA synthesis. The method can be employed in the synthesis of nucleosides with acetal and acetal ester groups for the protection of hydroxyl functions. The method according to the invention consists of the reaction of an organic compound containing at least one hydroxyl group, soluble in an aprotic solvent, with a compound of the general formula 1, R 1 -S-CH 2 -O-R 2 (1) in the presence of SnCl 4 , in an aprotic solvent. In the second aspect, the present invention is the method of protecting the hydroxyl function, particularly in position 2', in nucleoside derivatives, based on the incorporation of an acetal or acetal ester group.

专利号:US-8846898-B2
优先权日:2000-10-17
标题:Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge
发明人：DELLINGER DOUGLAS J
权利人:DELLINGER DOUGLAS J; Lieure Cornu LLC
摘要:Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III) n nwherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy, halogen, SH, NH 2 , azide or DL wherein D is O, S or NH and L is a heteroatom-protecting group, unsubstituted hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; B is a nucleobase; and one of R 11 and R 12 is a blocking group and the other is (IV) or (VI)n n nin which W, X, Y, Z, R 1 and n are as defined herein.

专利号:US-8362203-B2
优先权日:2009-02-10
标 题:Non-natural peptides as models for the development of antibiotics
发明人：CUNNINGHAM PHILIP R; CHOW CHRISTINE SHARON; ABEYDEERA NUWAN DINUKA; LAMICHHANE TEK NARAYAN
权利人:UNIV WAYNE STATE; CUNNINGHAM PHILIP R; CHOW CHRISTINE SHARON; ABEYDEERA NUWAN DINUKA; LAMICHHANE TEK NARAYAN
摘要:Described herein are methods of screening one of the RNA hairpins in the small ribosomal subunit of bacteria to identify peptides that bind to it. The RNA hairpin target may be the 970 loop (aka helix 31 (h31)) or a modified version thereof. The identified peptides may inhibit protein synthesis and, therefore, may be used as a model for new antibiotics.

专利号:US-2005059817-A1
优先权日:2000-09-01
标题 :Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
发明人：BEIGELMAN LEONID; KARPEISKY ALEXANDER; SEREBRYANY VLADMIR; HAEBERLI PETER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-0-silyl, 2′-O-triisopropylsilyloxymethyl, 2′-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

专利号:US-2025325575-A2
优先权日:
标题 :Synthesis of 3 -rna oligonucleotides