专利号:WO-2013144924-A1 优先权日:2012-03-29 标 题:An improved process for the synthesis of strobilurin fungicides viz trifloxystrobin and kresoxim-methyl 发明人:KAMARAJ PASUMPON; SATAM VIJAY SHRIKANT; AJJANNA MAHALINGAPPA SRIDHARA; NANDI TAPASKUMAR; BOBADE ANNA; SHINDE RAVINDRA; NAIK PARAG; MOHITE DHANAJI; KADAM SUBHASH; HINDUPUR RAMA MOHAN; PATI HARI NARAYAN; MANE AVINASH; VADIRAJ SUPHALA GOPINATH; VENKATESH PRABHU MOODBIDRI 权利人:RALLIS INDIA LTD 摘要:The present invention relates to an improved process for the synthesis of E -isomer of compound of formula (5). It further relates to the conversion of formula (5), wherein R is H, to Intermediate (I) and subsequently to substantially pure Trifloxystrobin, compound of formula (I) in good yield.
专利号:US-2023167051-A1 优先权日:2020-02-25 标 题 :A PROCESS FOR SYNTHESIS OF HIGH PURITY l-[3-(TRIFLUOROMETHYL)PHENYL]ETHANONE OXIME 发明人:GOENKA RAVI; AUDI AJAY A 权利人:LAXMI ORGANIC IND LTD 摘要:A process for preparation of 3-Trifluoromethyl acetophenone oxime of formula I includes reacting an isomeric mixture of halo benzotrifluoride with Mg metal in an organic solvent in presence of a catalyst to obtain a Grignard complex. The Grignard complex is reacted with a ketene in hydrocarbon solvent in presence of transition metal ligand-acid complex to obtain an isomeric mixture of trifluoromethyl acetophenone. Finally, the isomeric mixture of trifluoromethyl acetophenone is reacted with hydroxylamine salt to obtain compound of formula I.
专利号:US-6660884-B2 优先权日:2002-03-14 标 题 :Catalysts, methods for making said catalysts, and methods for making chiral compounds with high enantioselectivity 发明人:WALSH PATRICK J 权利人:UNIV PENNSYLVANIA 摘要:The present invention relates to compounds useful as catalysts in asymmetric synthesis of chiral compounds, methods for the synthesis of said catalysts, and methods for synthesizing chiral compounds with high enantioselectivity.
专利号:US-6005103-A 优先权日:1993-11-19 标题 :Pyrone derivatives as protease inhibitors and antiviral agents 发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:WARNER LAMBERT CO 摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
专利号:US-9062085-B2 优先权日:2010-09-10 标 题 :Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis 发明人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO 权利人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO; KANATA CHEMICAL TECHNOLOGIES INC 摘要:The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B))
专利号:EP-0729465-B1 优先权日:1993-11-19 标 题:Pyrone derivatives as protease inhibitors and antiviral agents 发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN 权利人:PARKE DAVIS & CO 摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
[参考文献]: Celina García, Et Al. Highly Enantioselective Catalytic Phenylation Of Ketones With A Constrained Geometry Titanium Catalyst. Org Lett. 2003 Oct 2;5(20):3641-4. [参考文献]: Serafino Gladiali, Et Al. Asymmetric Transfer Hydrogenation: Chiral Ligands And Applications. Chem Soc Rev. 2006 Mar;35(3):226-36.
合成参考文献
摘要:Takeda, T.; Tsubouchi, A., Science of Synthesis, (2010) 47, 258. 摘要:Lipshutz, B. H.; Ghorai, S., Science of Synthesis Knowledge Updates, (2014) 2, 178. 摘要:Okamoto, K.; Ohe, K., Science of Synthesis Knowledge Updates, (2020) 1, 89. 摘要:Wu, X.-F., Science of Synthesis Knowledge Updates, (2014) 1, 328. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 355.