CAS: 452-74-4; 1-Bromo-2-Fluoro-4-Methylbenzene

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4-甲基-2-硝基-N-乙酰基苯胺置于盐酸,氟硼酸钠,Claisen'S Base,硫酸,铁粉,溶剂黄146,Sodium Nitrite体系中,化学反应生成 4-溴-3-氟甲苯
参考文献:含氟的4-甲氧基甲基苄基高氯酸盐的合成及其杀虫活性
标题:含氟的4-甲氧基甲基苄基高氯酸盐的合成及其杀虫活性
摘要:为了研究含氟的4-甲氧基甲基苄基高氯酸酯的氟原子位置与杀虫活性之间的关系,合成了2-和3-氟-4-甲氧基甲基苄基(+/-)-顺式-高氯菊酯.测试了它们的杀虫活性,并讨论了标题化合物的氟效应.
DOI:10.1016/s0022-1139(02)00148-3

专利信息

专利号:WO-2020248279-A1
优先权日:2019-06-14
标 题 :Continuous synthesis method for substituted benzoate organic matter
发明人：HONG HAO; LU JIANGPING; ZHANG ENXUAN; LIU ZHIQING; LI CHAO
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a continuous synthesis method for a substituted benzoate organic matter. The continuous synthesis method comprises: in the presence of a catalyst and an organic solvent, continuously feeding an organic matter as represented by formula (I) and oxygen into a continuous reaction device for continuous oxidation reaction to obtain a substituted benzoate organic matter, and performing continuous discharge, wherein the substituted benzoate organic matter has a structure as represented by formula (II). Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters.

专利号:US-7169955-B2
优先权日:2000-02-04
标 题 :Perfluoroisopropylbenzene derivative
发明人：ONISHI MASANOBU; IKEDA KENICHI; SHIMAOKA TAKASHI; YOSHIDA MASANORI
权利人:NIHON NOHYAKU CO LTD
摘要:Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants: n nwherein X 1 is H, halogen, formyl, optionally halogenated (C 1 –C 6 ) alkyl, (C 1 –C 6 ) alkylthio, or the like; X 2 is H, halogen, formyl, hydroxyl, (C 1 –C 6 ) alkyl, —C(â•?O)—R 1 (wherein R 1 is H, halogen, hydroxyl, (C 1 –C 6 ) alkyl, or NR 2 R 3 , with R 2 and R 3 being each H, C 1-6 alkyl, or the like), or the like; X 3 is H, halogen, hydroxyl, cyano, isocyanate, hydrazino, diazo, —C(â•?O)—R 1 , —SO 2 —R 4 (wherein R 4 is halogen, hydroxyl, (C 1 –C 6 ) alkyl, or NR 5 R 6 , with R 5 and R 6 being each H or (C 1 –C 6 ) alkyl), or the like; and X 4 is H, halogen, (C 1 –C 6 ) alkyl, or (C 1 –C 6 ) alkoxy, with publicly known compounds beingexcepted.

专利号:CN-102372618-A
优先权日:2011-10-20
标题:Practical Synthesis of 2-Halo-1-(4-Bromo-3-fluorophenyl)ethanone

专利号:US-5334753-A
优先权日:1992-03-12
标题 :Processes for preparing ortho-substituted benzoic acids
发明人：BENNETAU BERNARD; CAIN PAUL A
权利人:RHONE POULENC AGRICULTURE
摘要:A novel process for the synthesis of ortho-substituted benzoic acid by lithiating an unprotected benzoic acid and a number of novel orth-substituted benzoic acids are described.

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:CN-117756601-A
优先权日:2023-12-18
标 题 :A kind of synthesis method of 2,2-difluoro-4,4-dimethyl-1,1-biphenyl