CAS: 462-34-0; Boron Trifluoride Tetrahydrofuran Complex

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CAS号110-51-0 硼烷吡啶络合物

四氢呋喃,三氟化硼 以 Petroleum Ether 作为反应溶剂,化学反应生成 三氟化硼四氢呋喃络合物
参考文献:High Specific Activity Preparation Of F-18 Tetrafluoroborate
标题:High Specific Activity Preparation Of F-18 Tetrafluoroborate
摘要:本发明实施例提供了一种通过对三氟化硼(bf3)进行直接放射氟化来合成18F-四氟硼酸盐(18F-Tfb)的方法,以提高标记产率和比活度.同时也考虑了18F-Tfb的用途.

专利信息

专利号:US-11976081-B2
优先权日:2019-04-26
标题 :Intermediate of eribulin and synthesis method and use thereof
发明人：XU WEIPING
权利人:BEIJING TIENYI LUFU PHARMATECH CO LTD
摘要:An intermediate compound is prepared and used for the synthesis of halichondrin B, eribulin or an analog thereof, particularly a structural fragment C27-C35 thereof. The starting materials of the synthetic route are readily available, and the optical purity of the starting materials can be ensured, so that the optical purity of the structural fragment C27-C35 in halichondrin B, eribulin or the analog thereof is ensured. Steps for constructing a chiral center of the structural fragment C27-C35 feature higher diastereoselectivity and yield, in particular preparation methods of compounds of formulae (X), (XI), (XVI) and (XV). By-products of partial reactions can be removed only by recrystallization, which results in easy purification and significant reduce in cost.

专利号:WO-2014128524-A1
优先权日:2013-02-19
标题:An improved process for preparation of an intermediate of the pyrrolidine substituted flavones
发明人：CHENNAMSETTY SUNEELMANOHARBABU; PATIL RAJENDRA; HAREL PRASHANT; HARIHARAN SIVARAMAKRISHNAN
权利人:PIRAMAL ENTPR LTD
摘要:The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)- trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or pharmaceutically acceptable salts thereof; which are inhibitors of cyclin dependant kinases (CDKs) and can be used in the treatment of proliferative disorders such as cancer. Formula (1) wherein R 1 has the meaning as indicated in the claims. The process of the present invention has advantages of higher yield and purity, lower reaction temperature, is consistent and involves the use of non toxic solvents. The process of the present invention allows efficient large-scale synthesis and purity of the product obtained is greater than 97 %.

专利号:WO-2014128523-A1
优先权日:2013-02-19
标 题 :A process for preparation of an intermediate of the pyrrolidine substituted flavones
发明人：CHENNAMSETTY SUNEELMANOHARBABU; BOKKA RAVISHANKAR; VEERAPPAN RATHINASAMI; SIVAKUMAR MEENAKSHI; HARIHARAN SIVARAMAKRISHNAN
权利人:PIRAMAL ENTPR LTD
摘要:The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)- trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or pharmaceutically acceptable salts thereof; which are inhibitors of cyclin dependant kinases (CDKs) and can be used in the treatment of proliferative disorders such as cancer. Formula (1) wherein R has the meaning as indicated in the claims. The process of the present invention has advantages of higher yield and purity, lower reaction temperature, is consistent and involves the use of non toxic solvents. The process of the present invention allows efficient large-scale synthesis and purity of the product obtained is greater than 97 %.

专利号:US-2024262834-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof
发明人：CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

专利号:US-9487537-B2
优先权日:2013-06-12
标 题:Synthesis of isohexide dicarbamates and derivatives thereof
发明人：STENSRUD KENNETH
权利人:ARCHER DANIELS MIDLAND CO; ARCHER DANIELS MIDLAND CO
摘要:Dicarbamates of the reduction products of 2-hydroxymethyl-5-furfural (HMF) and a method of preparing the same are described. The method involves reacting a mixture of an isohexide and a cynate salt in a non-aqueous solvent, with a miscible acid having a pKa of about 3.7 or less. The dicarbamates of HMF-reduction products can serve as precursor materials from which various derivative compounds can be synthesized.

专利号:US-4301129-A
优先权日:1978-09-18
标题 :Synthesis of NaBH3 CN and related compounds
发明人：WADE ROBERT C; HUI BENJAMIN C
权利人:THIOKOL CORP
摘要:A process for the preparation of compounds of the formula RBH 3 CN wherein R is an alkali metal, a quaternary ammonium radical or a phosphonium radical wherein a compound of the formula RCN is treated with a stoichiometric amount or slightly less than a stoichiometric amount of a BH 3 donor is described. The final products are useful as hydrolysis stable reductants and as synthetic intermediates.