CAS: 51673-84-8; 2,2-Dimethoxyacetaldehyde

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1,1-dimethoxy-2-butene methanol Glyoxal 2,2-dimethoxyethanol(Z)-4,4-Dimethoxy-but-2-enoic acid ethyl ester (E)-4,4-dimethoxy-but-2-enoic acid ethyl ester N-dodecyl N-(dimethoxy-2,2) ethylidene imine N-Benzhydryl-3,3-dimethoxy-2-(2-oxo-azetidin-1-yl)-propionamide

丙烯醛二甲缩醛置于potassium Permanganate,Potassium Carbonate体系中,用 水 作为反应溶剂,化学反应生成 乙二醛-1,1-二甲基乙缩醛溶液
参考文献:A3 Adenosine Receptor Antagonists
标题:A3 Adenosine Receptor Antagonists
摘要:揭示了吡啶和二氢吡啶衍生物,包括这些衍生物中的一个或多个的药物组合物,以及通过使用这些衍生物中的一个或多个来选择性地阻断哺乳动物的a3腺苷受体的方法.吡啶衍生物的一个例子如下式(i)所示:其中r2为乙基,R3为乙基硫基;r4为乙基,丙基或羟丙基;r5为乙基,丙基,氟乙基或氟丙基;r6为苯基或氟苯基.本发明的衍生物可用于抑制配体与腺苷受体的结合.这些衍生物还可用于表征腺苷受体.

专利信息

专利号:WO-2019202611-A1
优先权日:2018-04-21
标题:An improved process for the synthesis of ivabradine and its pharmaceutically acceptable salts
发明人：NANDEPU Venkateswara Rao; BOPPANA DURGA PRASAD
权利人:METROCHEM API PVT
摘要:: Disclosed herein is an improved process for the preparation of Ivabradine and pharmaceutically acceptable salts thereof. The invention more particularly disclosesthe synthesis of key intermediates viz.,(S)-N-[(4,5-dimethoxybenzocydobut-l-yl)-methyl]-N- (methyl)amine hydrochloride of Formula-II and 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapin-2-one of Formula-III, and its use in industrial synthesis of Ivabradine and pharmaceutically acceptable salts thereof.

专利号:US-8476426-B2
优先权日:2011-02-14
标题 :Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：PEGLION JEAN-LOUIS; DESSINGES AIMEE
权利人:PEGLION JEAN-LOUIS; DESSINGES AIMEE; SERVIER LAB
摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.

专利号:EP-2017267-A1
优先权日:2007-07-16
标 题:Synthesis of statins
发明人：KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ
权利人:LEK PHARMACEUTICALS
摘要:The process for synthesis of statins is presented where the intermediate intermediate (4 R ,6 S )-6-(dialkoxymethyl)tetrahydro-2 H -pyran-2,4-diol which already possesses the desired stereochemistry corresponding to final statin is prepared by an aldolaze.

专利号:EP-2465936-A1
优先权日:2010-12-20
标题 :Enzymatic synthesis of statins and intermediates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermdiate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or interemediate thereof.

专利号:US-8471045-B2
优先权日:2007-04-03
标题 :Synthesis of statins
发明人：CASAR ZDENKO; MESAR TOMAZ; KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ
权利人:CASAR ZDENKO; MESAR TOMAZ; KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ; LEK PHARMACEUTICALS
摘要:The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.

专利号:US-12006315-B2
优先权日:2022-03-25
标题 :Intermediate useful for the synthesis of TGF-beta inhibitors and a method of preparing TGF-beta inhibitors using the same
发明人：LEE SEUNG HO
权利人:MEDPACTO INC
摘要:The present invention provides an intermediate for synthesizing a TGF-β inhibitor represented by Chemical Formula 1 and an improved method for preparing the TGF-β inhibitor represented by Chemical Formula 1 using the same. The preparation method according to the present invention can not only allow inexpensive and safe reagents to be used, but also simplify the synthesis steps and purification methods to improve the reaction yield, thereby maximizing the production efficiency of the TGF-β inhibitor represented by Chemical Formula 1 to be used usefully for mass production.