CAS: 548-26-5; 2',4',5',7'-Tetrabromofluorescein) Disodium Salt

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CAS号518-45-6 荧光素 | CAS号15086-94-9 曙红Y(醇溶) | CAS号21514-87-4 曙红酒精

专利信息

专利号:WO-2023277824-A3
优先权日:2021-07-01
标 题:Diverse functionalization of hydrosilanes and programmable synthesis of multisubstituted organosilanes enabled by neutral eosin y photocatalysis
发明人：WU JIE; FAN XUANZI; ZHANG MULIANG
权利人:NAT UNIV SINGAPORE
摘要:Disclosed herein is a process to functionalise a hydrosilane, the process comprising the steps of: (a) providing a hydrosilane of formula (I); and (b) photochemically reacting the hydrosilane of formula (I) in the presence of a solvent, neutral Eosin Y, a reagent and, optionally, an additive, for a period of time in the presence of light and at a suitable temperature to provide a compound of formula (II). This functionalization enabled by Eosin Y photocatalysis allowed us to achieve modular and versatile stepwise decoration of a silicon atom from a di- or trihydrosilane for the synthesis of multisubstituted organosilanes.

专利号:US-2002055171-A1
优先权日:1998-05-27
标题 :Preparation of biologically active 3-methyleneoxindole and definition of its application in stimulation of plant growth and tissue repair
发明人：TULI VIRENDA KUMAR
摘要:Identification of the true nature and metabolic action of 3 -methyleneoxindole (MO), a naturally occurring catabolite of the plant auxin, indole- 3 -acetic acid (IAA). Description of the two novel methods of synthesis of MO which produce the pure, biologically active auxin compound of MO. Discovery and description of the causes for the erroneous classification of MO as an inert compound with no auxin activity. These findings and methods of synthesis correct the ubiquitous theoretical errors which have driven scientific investigation and plant science research of plant auxins for nearly forty years. n Researchers have failed to observe the auxin activity of MO because of the use of standard but incorrect synthetic techniques which have consistently produced impure forms of 3 -bromooxindole- 3 -acetic acid ( 3 -Brox), the synthetic precursor of MO. In addition, the use of dimethylsulfooxide as a solvent for MO has been identified as a major source of contamination of MO during synthesis. n This invention describes two novel methods for synthesizing (MO). By using purified MO and avoiding the use of dimethylsulfoxide, it was found that the resulting MO product to be 100 to 1,00 fold more effective than IAA in promoting rooting in plant cuttings; supporting tissue differentiation and growth in stage I, stage II and stage III media used for the micropropagation of explants; promoting the formation of callus tissue over wounded plant parts; and, stimulating the production of interstitial tissue between scion and rootstock to increase the success rate for grafting. Therefore, this invention identifies MO as the dominant auxin in shoot acceleration, root development, wound sealing and scion acceptance. n Finally, the correct pathway from IAA to MO is presented.

专利号:US-7541165-B2
优先权日:2001-10-30
标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:RIBOMED BIOTECHNOLOGIES INC
摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.

专利号:US-4345984-A
优先权日:1981-03-02
标题 :Novel prostaglandin analogues and process for making same
发明人：MIHELICH EDWARD D
权利人:PROCTER & GAMBLE
摘要:A novel process for the oxidation of olefins to the corresponding alpha-epoxy alcohols which can be incorporated in the total synthesis of members of a novel class of prostaglandin analogues. Olefins are reacted with singlet oxygen in the presence of a group IVB, VB or VIB transition metal catalyst, excluding chromium. The reaction is fast and highly selective to the alpha-epoxy alcohol. When cyclopentene is oxidized in the process of the invention, high yields of cis 2,3-epoxy-cyclopentan-1-ol are obtained. The latter compound is used as a starting material in the synthesis of prostaglandin analogues. The prostanoids of the invention are characterized by an oxa group replacing the methylene group at the 7-position, and the absence of a hydroxyl or other substituent at the 11-position. Members of this class of prostanoids show important cytoprotective properties in animal tests.

专利号:US-2005148042-A1
优先权日:2002-03-29
标 题 :Hybrid phosphoinositide phospholipids: compositions and uses
发明人：PRESTWICH GLENN; RZEPECKI PIOTR W; FERGUSON COLIN G; NEILSEN PAUL O; BRANCH ANGIE M; CROSBY LEE R
摘要:The methods and compositions disclosed herein concern the synthesis of a novel class of “two-headedâ€? phospholipid-phosphoinositide hybrids possessing a carbon backbone, such as 2,3-diacylthreitol, erythritol or a synthetic module. The second phospholipid head group allows introduction of a biochemical or chemical moiety in a position orthogonal in space to those occupied by the phosphoinositide head group and the two acyl chains. The diacyl moieties allow for the incorporation of Pea-PIP 2 into a lipid bilayer, while the Ptdlns(4,5)P 2 moiety in the aqueous layer is specifically recognized by lipid binding proteins. In alternative embodiments of the invention, reporters, for example biotin, fluorophores and/or spin labels, are attached to the free amino group of the head groups of such molecules to specifically target the reporters to the lipid-water interface.

专利号:US-7700375-B2
优先权日:2004-06-16
标 题 :Fluorescent labeling of specific protein targets in vitro and in vivo
发明人：KEILLOR JEFFREY W; MICHNICK STEPHEN W; GIROUARD STEPHANE
权利人:VALORISATION RECH LP
摘要:New methods are provided for the post-genomic era that will permit the analysis of the dynamic expression and localization of gene products in living cells. Herein we propose the development of such a method from a bioorganic approach involving organic synthesis and protein engineering. Specifically, novel compounds bearing two maleimide groups attached directly to fluorescent cores will be prepared, whose latent fluorescence is quenched until their maleimide groups undergo a specific thiol addition reaction. Complementary a-helical proteins are designed bearing two cysteine residues appropriately positioned to react with our novel fluorogens. Genetically fusing our helical probe peptides to test proteins of interest, we can selectively label the target sequence in living cells with our small synthetic fluorogenic molecules. The scope of this technique is described in the context of studying protein localization and protein-protein interactions in living cells.