9-蒽甲醛肟置于硫酸,水体系中,化学反应生成 9-蒽甲酸 参考文献:A Mild Oxidation Of Deactivated Naphthalenes And Anthracenes To Corresponding Para-Quinones By N-Bromosuccinimide 标题:A Mild Oxidation Of Deactivated Naphthalenes And Anthracenes To Corresponding Para-Quinones By N-Bromosuccinimide 摘要: DOI:10.1016/j.Tetlet.2014.04.088
专利号:US-6924375-B2 优先权日:2003-09-03 标题:Facile synthesis of 1,9-diacyldipyrromethanes 发明人:LINDSEY JONATHAN S; TAMARU SHUN-ICHI; YU LIANHE 权利人:UNIV NORTH CAROLINA STATE 摘要:The present invention provides a method of making a metal complex. The method comprises the steps of: (a) acylating a dipyrromethane or a 1-monoacyldipyrromethane to form a mixed reaction product comprising a 1,9-diacyidipyrromethane; (b) combining the reaction product with a compound of the formula R 2 MX 2 in the presence of a base, where R is alkyl or aryl, M is Sn, Si, Ge, or Pb (preferably Sn), and X is halo, OAc, acac, or OTf, to form a product comprising a metal complex of the formula DMR 2 in the mixed reaction product, wherein D is a 1,9-diacyldipyrromethane; and then (c) separating the metal complex from the mixed reaction product. The method may be utilized for the convenient synthesis and separation of 1,9-diacyldipyrromethanes. Metal complex intermediates useful in such methods are also described.
专利号:US-12441733-B2 优先权日:2018-03-26 标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors 发明人:ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS 权利人:NOVARTIS AG 摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.
专利号:US-7846714-B2 优先权日:1998-09-17 标 题 :Synthesis of chemical tags 发明人:SARAF RAVI F 权利人:IBM 摘要:A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule.
专利号:US-2011028688-A1 优先权日:2006-06-21 标 题 :Crystal structure of ox40l and ox40l complexed with ox40 receptor 发明人:HYMOWITZ SARAH; COMPAAN MCGUINN DEANNE 权利人:GENENTECH INC 摘要:The present disclosure provides crystals of and structural coordinates of mOX40L, hOX40L, hOX40 receptor and complexes thereof. The crystals and crystal structures are useful, for example, in the design and synthesis of modulators of mOX40L, hOX40L, and/or hOX40 receptor.
专利号:CN-111171080-B 优先权日:2020-01-08 标 题:Cell and in vivo autocatalytic synthesis of high-efficiency and low-toxicity anticancer compounds and their synthesis methods
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
[参考文献]: Cherian Ol, Menini A, Boccaccio A. Multiple Effects Of Anthracene-9-Carboxylic Acid On The Tmem16B/anoctamin2 Calcium-Activated Chloride Channel. Biochim Biophys Acta. 2015 Apr;1848(4):1005-13. [参考文献]: Piper As, Greenwood Ia. Anomalous Effect Of Anthracene-9-Carboxylic Acid On Calcium-Activated Chloride Currents In Rabbit Pulmonary Artery Smooth Muscle Cells. Br J Pharmacol. 2003 Jan;138(1):31-8. [参考文献]: Diego Crespo, Et Al. Tumor Necrosis Factor Alpha May Act As An Intraovarian Mediator Of Luteinizing Hormone-Induced Oocyte Maturation In Trout. Biol Reprod. 2012 Jan 10;86(1):1-12. [参考文献]: H A Azab, Et Al. Synthesis And Fluorescence Properties Of Eu-Anthracene-9-Carboxylic Acid Towards N-Acetyl Amino Acids And Nucleotides In Different Solvents. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Jan;75(1):21-7. [参考文献]: Joon-Chul Kim, Et Al. Shear Stress Induces A Longitudinal Ca(2+) Wave Via Autocrine Activation Of P2Y1 Purinergic Signalling In Rat Atrial Myocytes. J Physiol. 2015 Dec 1;593(23):5091-109.
合成参考文献
参考文献:10.1107/s0108270196011213|10.1107/s0108270197004927 摘要:Fitzgerald LJ, Gerkin RE. Anthracene-1-carboxylic acid. Acta Crystallogr C. 1997 Aug 15;53 ( Pt 8)():1080–2. doi: 10.1107/s0108270197004927.