CAS: 78834-75-0; Ethyl 7-Chloro-2-Oxoheptanoate

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874886-74-5 717919-91-0 62123-62-0

上下游产品

CAS号54512-75-3 1-溴-5-氯戊烷 | CAS号95-92-1 草酸二乙酯 | CAS号278605-08-6 5-chloro-n-pent... | CAS号1022895-93-7 ethyl (E)-7-chl... | CAS号2009-83-8 6-氯-1-己醇 | CAS号52387-36-7 6-氯己醛 | CAS号82009-34-5 西司他丁

6-氯-1-己醇置于硫酸,Potassium Bromide 盐酸,Sodium Hypochlorite,2,2,6,6-四甲基哌啶氧化物,水,碳酸氢钠,Sodium Hydrogensulfite体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 158.0H,反应生成 7-氯-2-氧代庚酸乙酯
参考文献:Intermediate Of Cilastatin And Preparation Method Thereof
标题:Intermediate Of Cilastatin And Preparation Method Thereof

专利信息

专利号:US-5268501-A
优先权日:1990-02-08
标 题 :Process for preparing haloketo acid derivatives
发明人：IKEDA TAKAHARU; KAI SEIICHI; MINAI MASAYOSHI
权利人:SUMITOMO CHEMICAL CO
摘要:Process for preparing haloketo acid derivatives [I]: ##STR1## wherein R is H or C 1-6 alkyl, and X is chlorine or bromine, which comprises reacting β-oxo-acid ester [II]: ##STR2## wherein R 1 is H or C 1-6 alkyl, R 2 is C 1-5 alkyl or OR 3 (R 3 is C 1-6 alkyl), and X is the same as above, with nitrosating agent [IV]: n n ONOR.sup.4 [IV] n n wherein R 4 is H, alkyl, halogen or SO 3 H to give 7-halo-2-hydroxyminoheptanoic acid ester [III]: ##STR3## wherein R 1 and X are the same as above, following by reacting the product with aldehyde or ketone; and intermediates therefor, and process for preparing said intermediates. Said haloketo acid derivatives are useful as intermediate for synthesis of cilastatin, which is useful as medicament, especially as dehydropeptidase inhibitor.

专利号:US-5202467-A
优先权日:1990-02-08
标题:Process for preparing haloketo acid derivatives
发明人：IKEDA TAKAHARU; KAI SEIICHI; MINAI MASAYOSHI
权利人:SUMITOMO CHEMICAL CO
摘要:Process for preparing haloketo acid derivatives [I]: ##STR1## wherein R is H or C 1-6 alkyl, and X is chlorine or bromine, which comprises reacting β-oxo-acid ester [II]: ##STR2## wherein R 1 is C 1-6 alkyl, R 2 is C 1-5 alkyl or OR 3 (R 3 is C 1-6 alkyl), and X is the same as above, with nitrosating agent [IV]: n n ONOR.sup.4 [IV] n n wherein R 4 is H, alkyl, halogen or SO 3 H to give 7-halo-2-hydroxyiminoheptanoic acid ester [III]: ##STR3## wherein R 1 and X are the same as above, followed by reacting the product with aldehyde or ketone; and intermediates therefor, and process for preparing said intermediates. Said haloketo acid derivatives are useful as intermediate for synthesis of cilastatin, which is useful as medicament, especially as dehydropeptidase inhibitor.