专利号:US-7344868-B2 优先权日:2003-06-03 标题:Method for synthesizing ceramide-type compounds 发明人:LASSALLE LAURENT; YVERGNAUX FLORENT 权利人:LASSALLE LAURENT; YVERGNAUX FLORENT 摘要:The invention relates to the fields of fatty substance chemistry, specifically of the ceramide-type compound synthesis. The invention resides substantially in the synthesis of ceramide-type compounds. Specifically, the aim of the invention is a new enzymatic synthesis method, comprising at least one amidification step and one esterification step, achieved through lipases, among fatty acids and/or esters thereof and amino alcohols. The resulting ceramide-type compounds can be used as cosmetic and/or pharmaceutical compositions, in particular as dermatological compositions in conjunction or in admixture with one or more suitable cosmetic and/or pharmaceutical excipients or carriers. The method has an interest particularly in the synthesis of active compounds useful in the fields of cosmetology and/or pharmacology and specifically of dermatology.
专利号:CN-104910009-A 优先权日:2015-06-25 标题 :A kind of method of ionic liquid catalyzed synthesis of pletil alcohol ester
专利号:US-2014186905-A1 优先权日:2011-08-15 标题 :Biotechnological synthesis process of organic compounds with the aid of an alkl gene product 发明人:SCHAFFER STEFFEN; GIELEN JASMIN; DECKER NICOLE; KIRCHNER NICOLE; HAAS THOMAS; POETTER MARKUS; HAEGER HARALD 权利人:SCHAFFER STEFFEN; GIELEN JASMIN; DECKER NICOLE; KIRCHNER NICOLE; HAAS THOMAS; POETTER MARKUS; HAEGER HARALD; EVONIK DEGUSSA GMBH 摘要:Subject matter of the invention is a biotechnological process for the production of organic compounds with the aid of at least one alkL gene product.
专利号:US-6949553-B2 优先权日:2001-06-18 标题 :Aliphatic compounds, their synthesis method, and utilization of the same 发明人:TAMAI TADAKAZU; YOSHIKAI KAZUYOSHI; NISHIKAWA MASAZUMI; OGASAWARA KUNIO; MUROTA ITSUKI 权利人:MARUHA CORP 摘要:The present invention relates to aliphatic compounds of the formula I, or stereoisomers thereof, or their pharmaceutically acceptable salts: n n nwherein A represents an optionally substituted CH 3 C n H (2n-2m) — (wherein n denotes an integer of 4 to 22, and m represents an unsaturation number which is an integer of 0 to 7), l represents an integer of 0 to 10, s represents 0 or 1, provided that when s is 0, p+q=4 or 5, but when s is 1, p+q=3 or 4, and in each case, either p or q is an integer of 1 or more, R represents an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and R A represents hydrogen or an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and their use in suppression of platelet aggregation, in suppression of inflammation, and in prevention and treatment of circulatory diseases.
专利号:US-4975441-A 优先权日:1988-03-23 标 题:Lactams, their synthesis and use in cosmetic compositions 发明人:GIBSON WALTER T 权利人:UNILEVER PATENT HOLDINGS 摘要:A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises: (i) a chemical inhibitor of glycosidase activity chosen from lactams having the structure: where A<1> and A<6> are -H, -CH3, - @@0, -CH2OT or @@@0 A<1> and A<6> being the same or different, and at least one of which being the group: @ @@o in a lactam ring; and where Q is -OT min , -NHT min or a lactam linkage to A<1> or A<6>; the Q groups being the same or different, and at least one of which is involved in a lactam linkage; and where T is the same or different and is chosen from -H, -CpH2p+1 or a metal ion, T min is -H or -COCpH2p+1, and p is an integer of from 1 to 22; provided that: where any of the Q groups is -OT min or -NHT min , then that group or groups can be of either stereochemical configuration with respect to the plane of the ring; and (ii) a cosmetically acceptable vehicle for the chemical inhibitor. Certain novel lactams are also claimed.
专利号:US-2020330400-A1 优先权日:2016-03-16 标 题:Methods for the treatment of cancer using coenzyme q10 and fatty acid metabolism inhibitors 发明人:GESTA STEPHANE; DIERS ANNE R; DADALI-ABEL TULIN 权利人:BERG LLC 摘要:Presented herein are methods for the treatment of oncological disorders by the co-administration of CoQ10 compositions and at least one fatty acid metabolism inhibitor. In one embodiment, the CoQ10 compositions are lipid-containing compositions. The fatty acid metabolism inhibitor may be an inhibitor of fatty acid synthesis, storage, transport or degradation. The fatty acid metabolism inhibitor may also be a modulator of fatty acid structure, for example a fatty acid desaturase or elongase. The fatty acid inhibitor may inhibit any molecule involved in fatty acid metabolism, such as fatty acid synthase (FASN), carnitine palmitoyltransferase 1 (CPT-1), long-chain 3-ketoacyl-CoA thiolase, or stearoyl-CoA desaturase-1 (SCD-1). In embodiments, the fatty acid metabolism inhibitor may be C75, Etomoxir, trimetazidine or A939572.
[参考文献]: Balasubramanian Narasimhan, Et Al. Design, Synthesis, Antibacterial, And Qsar Studies Of Myristic Acid Derivatives. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3023-9. [参考文献]: Elisabetta Bertol, Et Al. Fatty Acid Ethyl Esters In Hair: Correlation With Self-Reported Ethanol Intake In 160 Subjects And Influence Of Estroprogestin Therapy. Drug Test Anal. 2014 Sep;6(9):930-5. [参考文献]: Friedrich Martin Wurst, Et Al. Concentration Of Fatty Acid Ethyl Esters In Hair Of Alcoholics: Comparison To Other Biological State Markers And Self Reported-Ethanol Intake. Alcohol Alcohol. 2004 Jan-Feb;39(1):33-8. [参考文献]: Julia Klein, Et Al. Neonatal Hair Analysis As A Biomarker For In Utero Alcohol Exposure. N Engl J Med. 2002 Dec 19;347(25):2086. [参考文献]: Nadia De Giovanni, Et Al. Ethanol Contamination Leads To Fatty Acid Ethyl Esters In Hair Samples. J Anal Toxicol. 2008 Mar;32(2):156-9.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 参考文献:10.1016/s0379-0738(01)00456-x 摘要:Pragst F, Auwaerter V, Sporkert F, Spiegel K. Analysis of fatty acid ethyl esters in hair as possible markers of chronically elevated alcohol consumption by headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS). Forensic Sci Int. 2001 Sep 15;121(1-2):76–88. doi: 10.1016/s0379-0738(01)00456-x. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. 摘要:International Journal of Toxicology 29(Suppl. 3):162-186,2010