CAS: 13311-84-7; N-(4-Nitro-3-(Trifluoromethyl)Phenyl)Isobutyramide

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393-12-4 52806-53-8 51366-39-3

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CAS号1939-27-1 N-(3-(三氟甲基)苯基)异丁酰胺 | CAS号98-16-8 间三氟甲苯胺 | CAS号98-08-8 三氟甲苯 | CAS号393-11-3 4-硝基-3-三氟甲基苯胺 | CAS号79-30-1 异丁酰氯 | CAS号393-11-3 4-硝基-3-三氟甲基苯胺 | CAS号1579-89-1 4'-氨基-3'-(三氟甲基)乙酰苯胺 | CAS号39235-51-3 N-[4-氨基-3-(三氟甲基...

间氨基三氟甲苯置于n-甲基吗啉,三聚氯氰,硫酸,硝酸体系中,用 二氯甲烷 用作溶剂,化学反应 11.0H,反应生成氟他胺
参考文献:Novel And Gram‐scale Green Synthesis Of Flutamide
标题:Novel And Gram‐scale Green Synthesis Of Flutamide
摘要:Isobutyric Acid In The Presence Of Cyanuric Chloride And N-Methylmorpholine Was Converted Into Active Ester 3 At 0-5 Degrees C,And It Was Subsequently Treated With 3-Aminobenzotrifluoride 4 At 25 Degrees C To Furnish Corresponding Amide 5. This Amide Finally,On Nitration,Produced The Desired Product Flutamide,2-Methyl-N-[4-Nitro-3-(Trifluoromethyl) Phenyl] Propionamide 6 In Good Yield. By-Product 2,4,6-Trihydroxy-1,3,5-Triazine 7 Was Converted Into The Useful Starting Material Cyanuric Chloride 1 By Refluxing With N,N-Diethylamine And Pocl3.
Doi:10.1080/00397910500464848

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-7199257-B1
优先权日:1999-06-10
标题 :Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide
发明人：SOEROES BELA; TUBA ZOLTAN; GALIK GYOERGY; BOR ADAM; DEMETER ADAM; TRISCHLER FERENC; HORVATH JANOS; BRLIK JANOS
权利人:RICHTER GEDEON VEGYESZET
摘要:A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-6143887-A
优先权日:1998-05-14
标题:Process for the stereoselective synthesis of 16-substituted-4-aza-androstanones
发明人：GRATALE DOMINICK F; TOLMAN RICHARD L; SAHOO SOUMYA P
权利人:MERCK & CO INC
摘要:The novel process of the present invention involves the stereoselective synthesis of certain 16β-substituted 4-aza-5α-androstan-3-ones and the useful intermediates obtained therein.

专利号:US-7816544-B2
优先权日:2004-03-23
标 题:Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species
发明人：JONES II GUILFORD; GERARD BAUDOUIN; PORCO JR JOHN A
权利人:UNIV BOSTON
摘要:The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.