专利号:US-2021107859-A1 优先权日:2018-04-06 标题 :A process for the synthesis of carbon labeled organic compounds 发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.
专利号:US-10392364-B2 优先权日:2014-08-11 标题:Process for synthesis of lenalidomide 发明人:RAO RAMAKRISHNA; NANDIPATI RAMADEVI; GOODA RAVI; SHEWALKAR MUKESH PADMAKAR; BHADKE VENKAT VASANTRAO 权利人:AVRA LABORATORIES PVT LTD 摘要:Disclosed herein is an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof.
专利号:US-4209464-A 优先权日:1977-06-10 标题:Novel synthesis of 3-amino-2-methylbenzotrifluoride from N-(2-X-5-trifluoromethylphenyl)-S,S-dimethylsulfimide 发明人:STEINMAN MARTIN; WONG YEE S 权利人:SCHERING CORP 摘要:This invention relates to a novel process for preparing 3-amino-2-methylbenzotrifluoride, and to certain novel intermediates produced by the process. 3-Amino-2-methylbenzotrifluoride is a key intermediate useful in the preparation of valuable therapeutic agents such as, for example, 2-(2-methyl-3-trifluoromethyl)anilino nicotinic acid.
专利号:WO-2022222272-A1 优先权日:2021-04-19 标 题 :Synthesis process of 2-methyl-3-methoxybenzoic acid 发明人:GENG JINGKUN; Fang Zheneng; YAO LINXI; JI PINJUN; ZHANG YANCHAO; MIAO JUNHUI; WANG BOTAO 权利人:JIANGSU YONGAN CHEMICAL CO LTD 摘要:Disclosed is a synthesis process of 2-methyl-3-methoxybenzoic acid. The synthesis process comprises the following steps: (1) a reductive hydrogenation reaction, involving: using 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst to prepare 3-amino-2-methylbenzoic acid or methyl 3-amino-2-methylbenzoate by means of hydrogenation reduction; (2) a one-pot reaction of diazotization, hydrolysis and esterification, involving: using the reduction product as a raw material and methanol as a solvent to prepare methyl 3-hydroxy-2-methylbenzoate by means of diazotization, hydrolysis and esterification reactions under the action of a diazotization reagent; (3) a methylation reaction, involving: using methyl 3-hydroxy-2-methylbenzoate as a raw material and dimethyl sulfate as a methylation reagent to prepare methyl 3-methoxy-2-methylbenzoate by means of a methylation reaction in the presence of an alkali; and (4) a hydrolysis reaction, involving: mixing methyl 3-methoxy-2-methylbenzoate with an alkali and water, and heating same for hydrolysis, cooling same after the reaction is completed, adjusting the pH to 1-3 with an acid to precipitate a product, followed by filtering and drying same to obtain 3-methoxy-2-methylbenzoic acid.
专利号:US-2018334443-A1 优先权日:2014-08-11 标题:An improved process for synthesis of lenalidomide
专利号:US-9522899-B2 优先权日:2009-06-01 标 题:Methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2, 6-dioxopiperidine, and intermediates thereof 发明人:YAN RONG; YANG HAO; XU YONGXIANG 权利人:NANJING CAVENDISH BIO-ENGINEERING TECH CO LTD; YAN RONG; NANJIAN CAVENDISH BIO-ENGINEERING TECH CO LTD 摘要:The present invention discloses methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2,6-dioxopiperidine and intermediates thereof, namely, the synthesis of compounds of the Formula (I), with each substitutional group defined in the patent specification. Owing to the advantages of high productivity, little influence to the environment and material accessibility, the methods of the present invention is suitable for industrial production.