专利号:US-12071421-B2 优先权日:2011-11-29 标题:Process for the synthesis of substituted chloromethyl dialkylphosphates
专利号:US-7893271-B2 优先权日:2005-07-28 标 题 :Benzimidazole carbamates and (thio) carbamates, and the synthesis and use thereof 发明人:CHASSAING CHRISTOPHE PIERRE ALAIN 权利人:INTERVET INT BV 摘要:This invention relates to benzimidazole carbamates and (thio)carbamates corresponding to Formula I: n nHere, X 1 and X 2 are independently O or S, wherein at least one of X 1 and X 2 is O; Y 1 and Y 2 are independently O or S, wherein at least one of Y 1 and Y 2 is O; R 1 is alkyl having from 1-4 carbon atoms; R 2 , R 3 , and R 4 are independently hydrogen or a cation; R 5 and R 6 are independently hydrogen, halogen, alkyl (having from 1-8 carbon atoms), —OR 7 , —SR 8 , —CO—R 9 , —OSO 2 —Ar, or —S(O)R 10 ; R 7 is alkyl having from 1-8 carbon atoms; R 8 is alkyl (having from 1-8 carbon atoms) or aryl; R 9 is alkyl (having from 1-8 carbon atoms), cycloalkyl (having from 3-6 carbon atoms), or aryl; Ar is aryl; and R 10 is alkyl (having from 1-8 carbon atoms) or aryl. The compounds generally are soluble and stable in water, and have antiparasitic (particularly anthelmintic) activity in vivo that is comparable to known water-insoluble benzimidazole carbamates (e.g., albendazole and fenbendazole).
专利号:CN-102482305-A 优先权日:2009-07-02 标 题 :N4-(2,2-Dimethyl-4-[(dihydrophosphonooxy)methyl]-3-oxo-5-pyrido[1,4]oxazin-6-yl)-5- Synthesis of Disodium Salt of Fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine
专利号:US-8299242-B2 优先权日:2009-07-02 标 题 :Synthesis of 2,4-pyrimidinediamines
专利号:US-8481724-B2 优先权日:2009-07-02 标题:Synthesis of 2,4-pyrimidinediamines