4-氟-2-硝基苯胺置于三氯化铁 盐酸,氢氧化钾,硫酸,一水合肼,锌,Sodium Nitrite体系中,用 乙醇 用作溶剂,化学反应 25.0H,反应生成3-氟苯硫酚 参考文献:Protiva,Miroslav; Jilek,Jiri; Cervena,Irena,Collection Of Czechoslovak Chemical Communications,1986,Vol. 51,# 11,P. 2598-2616 标题:Protiva,Miroslav; Jilek,Jiri; Cervena,Irena,Collection Of Czechoslovak Chemical Communications,1986,Vol. 51,# 11,P. 2598-2616
专利信息
专利号:US-10150160-B2 优先权日:2014-12-04 标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles 发明人:PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT 权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A 摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.
专利号:US-9365494-B2 优先权日:2008-12-18 标 题 :Process for synthesis of amino-methyl tetralin derivatives 发明人:DURKIN KIERAN; FISHER LAWRENCE EMERSON; MEILI ARTHUR; SCALONE MICHAELANGELO; SHI XIANQING; VITALE JUSTIN 权利人:DURKIN KIERAN; FISHER LAWRENCE EMERSON; MEILI ARTHUR; SCALONE MICHAELANGELO; SHI XIANQING; VITALE JUSTIN; ROCHE PALO ALTO LLC 摘要:Methods for producing a compound of formula k1 or k2 n nby reducing a dihydronapthalene amide compound of formula in n nwith hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2n nRu(Z) 2 (L)  j1;n nRu(E)(E′)(L)(D)  j2;n nwherein m, n, Ar, Y, R 1 E, E′, D, Z and L are as defined herein.
专利号:US-2016318862-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds 发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.
专利号:US-9481685-B2 优先权日:2008-10-02 标 题:Imaging neuroinflammation 发明人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN 权利人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; GE HEALTHCARE LTD 摘要:The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tissues expressing higher levels of PBR. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. A cassette for the automated synthesis of the in vivo imaging agent is also provided. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.
专利号:US-9751851-B2 优先权日:2013-09-20 标 题:Molecules and compositions that inhibit gram negative bacteria and their uses 发明人:BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T 权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T 摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.
专利号:EP-2104157-A1 优先权日:2006-12-29 标题 :Solution containing organic el material, method for synthesis of organic el material, compound synthesized by the synthesis method, method for formation of thin film of organic el material, thin film of organic el material, organic el element