CAS: 508233-74-7; 1-(2-((2,4-Dimethylphenyl)Thio)Phenyl)Piperazine

上下游产品

CAS号960203-27-4 氢溴酸沃替西汀 | CAS号110-85-0 哌嗪 | CAS号960203-41-2 1-[(2-溴苯基)硫基]-2... | CAS号583-55-1 2-溴碘苯 | CAS号13616-82-5 2,4-二甲基苯硫酚 | CAS号960203-27-4 氢溴酸沃替西汀

沃替西汀氢溴酸盐 以 异丙醇,水 作为反应溶剂,化学反应生成 沃替西汀
参考文献:Purification Of 1-[2-(2,4-Dimethylphenylsulfanyl)Phenyl]Piperazine
标题:Purification Of 1-[2-(2,4-Dimethylphenylsulfanyl)Phenyl]Piperazine
摘要:本发明涉及一种制备1-[2-(2,4-二甲基苯基硫基)苯基]哌嗪的方法.

专利信息

专利号:US-10562872-B2
优先权日:2016-02-08
标 题 :Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
发明人：DINESS FREDERIK; MELDAL MORTEN; JACOBSEN CHRISTIAN BORCH
权利人:H LUNDBECK AS
摘要:The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.

专利号:US-12180182-B2
优先权日:2021-12-01
标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same
发明人：DAI MINGJI
权利人:PURDUE RESEARCH FOUNDATION
摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

专利号:US-9493409-B2
优先权日:2013-04-04
标题 :Process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides new intermediate compounds or formulae (III) and (IVa), and salts thereof, and their use in a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine) an experimental drug under development for the treatment of depression and anxiety.

专利号:WO-2014191548-A1
优先权日:2013-05-31
标题:New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), an experimental drug under development for the treatment of depression and anxiety, which comprises the reaction of a compound of formula (VII), or salt thereof, (VII) wherein Q represents S, SO or SO 2 and LG represents a leaving group, with a compound of formula (XI), or salt thereof, (XI) wherein Z represents hydrogen or a protecting group. New intermediate compounds are also provided.

专利号:WO-2015107057-A1
优先权日:2014-01-14
标 题:Synthesis of vortioxetine via (2-(piperazine-1 -yl)phenyl)aniline intermediates
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4- dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)aniline intermediates.

专利号:WO-2015079018-A1
优先权日:2013-11-29
标题:Synthesis of vortioxetine via (2-(piperazine-1 -yl)phenvl)lithium intermediates
发明人：ZUPANCIC BORUT; STERK DAMJAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)lithium intermediates.