CAS: 5162-44-7; 4-Bromo-1-Butene

上下游产品

CAS号38771-21-0 4-溴正丁炔 | CAS号627-27-0 3-丁烯-1-醇 | CAS号110-52-1 1,4-二溴丁烷 | CAS号778-29-0 but-3-enyl 4-me... | CAS号13287-42-8 4-溴-1,2-环氧丁烷 | CAS号6773-29-1 重氮丙二酸二甲酯 | CAS号5911-08-0 氯甲基环丙烷 | CAS号65032-54-4 3-bromopropanal | CAS号20667-19-0 甲基三苯基碘化鏻 | CAS号50-00-0 甲醛 | CAS号104886-22-8 1-but-3-enoxy-3... | CAS号105534-98-3 4-but-3-enoxybe... | CAS号108144-23-6 N-but-3-enyl-N-... | CAS号3710-30-3 1,7-辛二烯 | CAS号38300-67-3 1, 2, 4-三溴丁烷 | CAS号142283-61-2 8-but-3-enyl-1,... | CAS号141943-25-1 4,4-dimethyl-2-... | CAS号14660-39-0 lithium,but-1-ene | CAS号1731-86-8 十一酸甲酯 | CAS号54716-25-5 methyl tetradec...

4-溴-1-丁炔置于二异丁基氢化铝体系中,用 正己烷 作为反应溶剂,以90%的收率获得产物4-溴-1-丁烯
参考文献:金属促进环化.18. (.Omega.-Halo-1-Alkenyl) 金属衍生物的新型环烷基化反应.合成范围和机制
标题:金属促进环化.18. (.Omega.-Halo-1-Alkenyl) 金属衍生物的新型环烷基化反应.合成范围和机制
摘要:环化 D'(ω-Halogenoalcene-1yl) M Et D'([ω-Halogeno Trimethylsilyl-1] Alcene-1yl) M 环烯(m = 铝,锌,锆,硅)
DOI:10.1021/ja00224A025

专利信息

专利号:US-6800785-B1
优先权日:2002-10-15
标题:Process for the synthesis of estrogen receptor modulators
发明人：MENG DONGFANG
权利人:MERCK & CO INC
摘要:The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone.

专利号:US-7358382-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

专利号:US-7368568-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-6933385-B2
优先权日:2001-08-03
标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:SCHERING AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-9403854-B2
优先权日:2001-03-30
标 题 :Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene complexes as metathesis catalysts
发明人：GRUBBS ROBERT H; CHATTERJEE ARNAB K; CHOI TAE-LIM; GOLDBERG STEVEN D; LOVE JENNIFER A; MORGAN JOHN P; SANDERS DANIEL P; SCHOLL MATTHIAS; TOSTE F DEAN; TRNKA TINA M
权利人:CALIFORNIA INST OF TECHN
摘要:The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.

专利号:US-6872727-B1
优先权日:1999-08-26
标 题:Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation
发明人：HERRMANN KONRAD; LEISTNER SIEGFRIED; WIPPICH PETRA
权利人:PRIVATES INST FUR BIOMEDIZINIS
摘要:Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their chemical and structural characterization, and the analysis of their physiological/pharmacological activities in vitro and in vivo. These goals have been attained by the specification of routes of synthesis, methods for the production of the compounds, and the presentation of compound-specific characteristics. The substances encompassed by the present invention demonstrate pharmacologically significant collangenase/matrix metalloproteinase inhibitory activities. The specific example 1-(3-mercaptoprop-1-yl)-3-methyl-chinazolin-2,4(1H,3H)-dione will be presented in detail.