CAS: 56718-71-9; P-(2-Methoxyethyl) Phenol

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CAS号501-94-0 对羟基苯乙醇 | CAS号32136-81-5 1-(4-羟基苯基)-2-甲氧基乙酮 | CAS号98627-35-1 1-(Benzyloxy)-4... | CAS号616-38-6 碳酸二甲酯 | CAS号144-55-8 碳酸氢钠 | CAS号14140-15-9 4-羟基苯乙基溴 | CAS号124-41-4 甲醇钠 | CAS号61439-59-6 2-(4-苯甲氧基苯基)乙醇 | CAS号2491-38-5 α-溴代对羟基苯乙酮 | CAS号56718-70-8 3-[4-(2-甲氧基乙基)苯... | CAS号56718-76-4 美托洛尔相关物质B | CAS号51384-51-1 1-[4-(2-甲氧基乙基)苯... | CAS号192575-81-8 (2S)-1,1-difluo... | CAS号81024-43-3 (R)-美托洛尔 | CAS号81024-42-2 (S)-美托洛尔 | CAS号62572-90-1 美托洛尔杂质D | CAS号105780-38-9 吡氟甲禾灵 | CAS号133397-54-3 (R)-3-[4-(2-Met... | CAS号881181-57-3 2-[1-(2-methoxy...

L-酪氨酸置于碘苯二乙酸,氨体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 4-(2-甲氧基乙基)苯酚
参考文献:碘硝烯的作用:将氨基酸直接转化为末端二氮杂环和 15N2-二氮杂环及其作为超极化标记物的应用
标题:碘硝烯的作用:将氨基酸直接转化为末端二氮杂环和 15N2-二氮杂环及其作为超极化标记物的应用
摘要:已经使用二乙酸苯基碘鎓 (Pida) 和氨开发了一种将未受保护的氨基酸一锅无金属转化为末端二氮丙啶的方法.这种 Pida 介导的转化通过三个连续的反应发生,并涉及碘化氮中间体.这种方法可以耐受氨基酸侧链上的大多数官能团,操作简单,可以放大以提供数克数量的二氮嗪.有趣的是,我们还证明了这种转化可以应用于没有外消旋化的二肽.此外,可以获得 14N2 和 15N2 同位素异构体,这强调了使用 15Nh3 时的关键转亚胺化步骤.此外,我们报告了直接产生不对称碳的 14N/15N 同位素异构体的首次实验观察.最后,
DOI:10.1021/jacs.9B07035

专利信息

专利号:US-4777293-A
优先权日:1984-08-13
标题 :Method for the synthesis of pharmacologically active compounds and intermediates for such synthesis
发明人：LAMM BO R
权利人:HAESSLE AB
摘要:A process for the preparation of an aryloxypropanolamine of the formula n n Ar--OCH.sub.2 CH(OH)CH.sub.2 NH--R I n n wherein Ar is a carbocyclic or heterocyclic aromatic group and R is an alkyl or substituted alkyl group having 1 to 6 carbon atoms, characterized in subjecting a compound of the formula ##STR1## to oxidative cleavage to a dialdehyde of the formula ##STR2## which is then made subject to reduction, amination, acetal hydrolysis, and, where required, removal of a nitrogen protective group, to the formation of a compound of formula I, or an acid addition salt thereof, a compound of formula II and the preparation thereof from mannitol.

专利号:US-5190867-A
优先权日:1986-05-08
标题:Process for the preparation of R-2,2-R1,R2 -1,3-dioxolane-4-methanol
发明人：BERTOLA MAURO A; MARX ARTHUR F; KOGER HEIN S; CLAASSEN VOLKERT P; PHILLIPS GARETH T
权利人:SHELL INTERNATIONAL PETROLEUM
摘要:Process for the preparation of R-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol wherein R 1 and R 2 are H or alkyl groups or wherein R 1 and R 2 together with the carbon atom to which they are attached form a carbocyclic ring by subjecting a mixture of R- and S-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol to the action of a micro-organism or substances derived therefrom having the ability for stereoselective consumption of S-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol preferably until at least 80 wt % and more preferably all the S-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol is consumed. Various micro-organisms of the genus Rhodococcus, Nocardia and Corynebacterium are disclosed as suitable for the purpose. The R-isomer is a valuable intermediate for stereospecific synthesis of various biologically active compounds including S-metoprolol.

专利号:EP-0244912-B1
优先权日:1986-05-08
标 题 :A process for the preparation of r and s-2,2-r1,r2-1,3-dioxolane-4-methanol
摘要:Process for the preparation of R-2,2-R1, R2-1,3-dioxolane-4-methanol wherein R1 and R2 are H or alkyl groups or wherein R1 and R2 together with the carbon atom to which they are attached form a carbocyclic ring by subjecting a mixture of R- and S-2,2-R1, R2-1,3-dioxolane-4-methanol to the action of a micro-organism or substances derived therefrom having the ability for stereoselective consumption of S-2,2-R1, R2-1,3-dioxolane-4-methanol preferably until at least 80 wt% and more preferably all the S-2,2-R1, R2-1,3-dioxolane-4-methanol is consumed. Various micro-organisms of the genus Rhodococcus, Nocardia and Corynebacterium are disclosed as suitable for the purpose. The R-isomer is a valuable intermediate for stereospecific synthesis of various biologically active compounds including S-metoprolol.

专利号:CN-112645827-A
优先权日:2020-12-25
标题 :A kind of method for continuous synthesis of Metoprolol and its salt

专利号:EP-0179031-B1
优先权日:1984-08-13
标 题:Method for the synthesis of pharmacologically active aryloxypropanol amine compounds

专利号:RU-2100341-C1
优先权日:1996-05-30
标 题:4-methoxyalkyl-2-tert-butylphenols as intermediate compounds for synthesis of metoprolol and its analogs