CAS: 1007-15-4; 3'-Bromo-4'-Fluoroacetophenone

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3-溴-4-氟苯甲酸置于carbonyldiimidazole,Methylmagnesium Chloride体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 1.5H,反应生成3-溴-4-氟苯甲酮
参考文献: Inhibitors Of The Renal Outer Medullary Potassium Channel[fr] Inhibiteurs Du Canal Potassique Médullaire Externe Rénal
标题: Inhibitors Of The Renal Outer Medullary Potassium Channel[fr] Inhibiteurs Du Canal Potassique Médullaire Externe Rénal
摘要:本发明提供了式ia的化合物及其药用可接受的盐,这些化合物是romk(kir1.1)通道的抑制剂.这些化合物可用作利尿剂和/或钠利尿剂,并用于治疗和预防包括高血压,心力衰竭以及与过多盐分和水分潴留有关的医疗状况等心血管疾病.

专利信息

专利号:US-4446075-A
优先权日:1980-02-22
标 题:Substituted bromofluorobenzene derivatives and process for its manufacture
发明人：EIGLMEIER KURT; KNIEPS REINHARD
权利人:RIEDEL DE HAEN AG
摘要:Substituted bromofluorobenzene, wherein the fluorine is in para-position and the bromine in meta-position to another substituent, is prepared by direct bromination of the corresponding fluorobenzene derivative. Bromination is advantageously carried out in the presence of a catalyst, preferably a metal or metal salt. The elementary bromine is used in an amount of 0.9 to 1.3 mols per mol of fluorobenzene derivative and the reaction temperature is between 20° and 200° C. The bromofluorobenzene derivatives are suitable for the synthesis of medicaments and plant protective agents.