专利号:US-11059914-B2 优先权日:2016-12-21 标题:Method for the continuous synthesis of a diene elastomer with lithium amide initiator 发明人:DIRE CHARLOTTE; DESSENDIER MARIE-HÉLÈNE 权利人:MICHELIN & CIE 摘要:A process for the continuous synthesis of a diene elastomer is provided. The synthesis is conducted by means of n reactors r1 to rn, considered to be continuous stirred-tank reactors, which are equipped with an internal stirring system. The reactors are arranged in series, n varying from 2 to 15, preferably from 2 to 9. The reactor r1 is fed by an input solution comprising a solvent, one or more monomer(s), an anionic polymerization initiator chosen from lithium amides and a polar agent. The conversion by weight C1 in the first reactor is less than 70%, and the total conversion by weight Cn at the outlet of the reactor rn is greater than or equal to 70%.
专利号:US-2008280855-A1 优先权日:2005-06-22 标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles 发明人:CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO 权利人:NYCOMED GMBH 摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
专利号:WO-2018115169-A1 优先权日:2016-12-21 标题 :Method for continuous polymerisation of diene elastomer with lithium amide initiator 发明人:DESSENDIER MARIE-HÉLÈNE; DIRE CHARLOTTE; FAUVARQUE-NUYTTEN CLAIRE 权利人:MICHELIN & CIE 摘要:The invention relates to a method for continuous synthesis of a diene elastomer by means of n reactors r1 to rn, provided with an internal stirring system, assumed to be perfectly stirred, arranged in series, n ranging from 2 to 15, preferably from 2 to 9, the reactor r1 being supplied with an input solution comprising a solvent, one or more monomers, an anionic polymerisation initiator chosen among the lithium amides and a polar agent, one or more reactors r2 to rn optionally also being supplied by re-injection of a purified solution comprising solvent and/or one or more monomers and/or polar agent, the temperature of each reactor ranging from 20°C to 150°C, preferably ranging from 30°C to 120°C and being no lower than the temperature of the reactor that immediately precedes same, the temperature of the reactor rn being higher than the temperature of the reactor r1, the diene elastomer obtained having a polymolecularity index ranging from 1.1 to 1.7.
专利号:WO-9700244-A1 优先权日:1995-06-19 标题 :Process for parallel synthesis of a non-peptide library 发明人:FRITZ JAMES E; KALDOR STEPHEN W 权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W 摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.
专利号:US-11198743-B2 优先权日:2016-12-21 标 题 :Method for continuous polymerization of modified diene elastomer with lithium amide initiator 发明人:DESSENDIER MARIE-HÉLÈNE; DIRE CHARLOTTE; FAUVARQUE-NUYTTEN CLAIRE 权利人:MICHELIN & CIE 摘要:A process for the continuous synthesis of a modified diene elastomer comprising at least one silicon atom directly connected to the elastomer chain is provided. The process comprises polymerization by n reactors r1 to rn, considered to be continuous stirred-tank reactors equipped with an internal stirring system and arranged in series, n varying from 2 to 15. The reactor r1 is fed by an input solution comprising a solvent, one or more monomer(s), an anionic polymerization initiator chosen from lithium amides and a polar agent. The temperature of each reactor varies from 20° C. to 150° C. and is greater than or equal to the temperature of the reactor which immediately precedes it. The living diene elastomer obtained exhibits a polydispersity index varying from 1.1 to 1.7. The process further comprisesmodification of the living diene elastomer obtained in the preceding stage by a functionalization, coupling or star-branching agent.
专利号:WO-2007141253-A1 优先权日:2006-06-07 标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines 发明人:PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO 权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO 摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
[参考文献]: Jeff Defalco, Et Al. 5-Benzyloxytryptamine As An Antagonist Of Trpm8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9.
合成参考文献
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