CAS: 151911-32-9; (S)-3-Amino-3-(2-Fluorophenyl)Propanoic Acid

相似化合物

117391-49-8 507472-13-1 500789-03-7

上下游产品

CAS号1393363-72-8 tert-butyl (S)-... | CAS号446-52-6 邻氟苯甲醛

Tert-Butyl (S)-3-Amino-3-(2'-Fluorophenyl)Propanoate置于盐酸,水,Ammonium Hydroxide体系中,用 水 用作溶剂,化学反应 6.0H,以96%的收率获得(S)-3-氨基-3-(2-氟苯基)-丙酸
参考文献:Asymmetric Synthesis Of β-Fluoroaryl-β-Amino Acids
标题:Asymmetric Synthesis Of β-Fluoroaryl-β-Amino Acids
摘要:The Conjugate Addition Of Lithium (R)-N-Benzyl-N-(Alpha-Methylbenzyl)Amide To A Range Of Beta-Fluoroaryl-Alpha,Beta-Unsaturated Esters Gave The Corresponding Beta-Amino Esters With High Diastereoselectivity And In Good Isolated Yields. Sequential Treatment Of The Resultant Beta-Fluoroaryl-Beta-Amino Esters Under Optimised Hydrogenolysis Conditions,Followed By Ester Hydrolysis With 2.0 M Aq Hcl,Provided Access To A Range Of Beta-Fluoroaryl-Beta-Amino Acids In Good Yield. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2012.07.001

专利信息

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2019330618-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries