CAS: 199327-61-2; 7-Methoxy-6-(3-Morpholinopropoxy)Quinazolin-4(3H)-One

上下游产品

CAS号184475-35-2 吉非替尼 | CAS号246512-44-7 2-氨基-4-甲氧基-5-(3... | CAS号64-18-6 甲酸 | CAS号77287-34-4 甲亚胺酸 | CAS号214472-41-0 2-氨基-4-甲氧基-3-(3... | CAS号675126-26-8 4-甲氧基-5-(3-吗啉丙氧... | CAS号1208902-96-8 7-methoxy-6-(3'... | CAS号6702-50-7 异香兰酸甲酯 | CAS号847949-49-9 4-[(3-氯-4-氟苯基)氨... | CAS号184475-35-2 吉非替尼

N-(3-氯丙基)吗啉置于氢氧化钾,Sodium Dithionite,硫酸,硝酸,Potassium Carbonate,Formamide,溶剂黄146体系中,用 2-甲基-2-丁醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 67.0H,反应生成7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3H)-酮
参考文献:合成[11C] Iressa作为表皮生长因子受体酪氨酸激酶的新型潜在pet癌症显像剂.
标题:合成[11C] Iressa作为表皮生长因子受体酪氨酸激酶的新型潜在pet癌症显像剂.
摘要:Iressa(吉非替尼)是一种表皮生长因子受体酪氨酸激酶(egfr-Tk)的口服活性抑制剂,参与对癌细胞增殖,凋亡,修复和血管生成至关重要的细胞信号转导过程.[11C] Iressa最初被设计和合成为egfr-Tk的新型潜在正电子发射断层扫描(pet)癌症成像剂,放射化学产率为30-40%,轰击结束时(eob)的比活为4.0-6.0 Ci / Micromol.
Doi:10.1016/j.Bmcl.2006.04.080

专利信息

专利号:WO-2011147102-A1
优先权日:2010-05-28
标题 :Synthetic method for 6,7-substituents-4-aniline quinazoline
发明人：SHIH KAE-SHYANG; HSIEH YU-JUNG; LIU CHING-WEI
权利人:SHYANG JEN BIOTECH CO LTD; SHIH KAE-SHYANG; HSIEH YU-JUNG; LIU CHING-WEI
摘要:A method for the synthesis of 6,7-substituents-4-aniline quinazoline is disclosed, in which 3,4-substituted benzoic acid is used as a starting material and 6,7-substituents-4-aniline quinazoline is produced from it by esterification, O-alkylation, nitration, nitro group reduction, cyclization, and two-in-one reaction of chlorination and amine-substitution, or by esterification, O-alkylation or nitration, hydrolysis-demethylation, esterification, O-alkylation, nitro group reduction, cyclization, and two-in-one reaction of chlorination and amine-substitution.

专利号:CN-103923023-B
优先权日:2014-04-11
标 题 :A new method for microwave synthesis of gefitinib and its derivatives

专利号:CN-101863844-B
优先权日:2009-04-16
标题:Synthesis method of 6, 7-substituent-4-aniline quinazoline