专利号:WO-2007132119-A1 优先权日:2006-05-15 标 题 :In situ or one-pot hydrogenation and reductive amination method 发明人:BURGOS ALAIN; CAILLE JEAN-CLAUDE; LORRAINE GRADLEY MICHELLE; FREIN STEPHANE; DERRIEN YVON; CHENARD ERIC 权利人:PPG SIPSY; NOVACTA BIOSYSTEMS LTD; BURGOS ALAIN; CAILLE JEAN-CLAUDE; LORRAINE GRADLEY MICHELLE; FREIN STEPHANE; DERRIEN YVON; CHENARD ERIC 摘要:The invention relates to a method for the synthesis of an ester compound of the trans-4-amino-cyclohexane carboxylic acid of formula (I). Said method is characterised in that the ester (I) is obtained, in the form of a salt or otherwise, from a compound of formula (II) by means of a Hoffmann rearrangement reaction and optionally transesterification according to diagram A wherein R represents an alkyl, aryl or alkylaryl grouping. The invention provides a very high yield of said ester in an essentially trans form using a method involving few steps.
专利号:CN-109422730-A 优先权日:2017-08-27 标 题 :A class of non-natural amino acid derivatives containing azetidine skeleton and synthesis method thereof
专利号:CN-109422730-B 优先权日:2017-08-27 标题 :A class of non-natural amino acid derivatives containing azetidine skeleton and synthesis method thereof
参考文献:10.1007/bf00925310 摘要:Karpavichyus KI, Patotskene LA, Knunyants IL. Synthesis of peptide-like derivatives of cis- and trans-4-aminocyclohexanecarboxylic acids containing sarcolysine. Russian Chemical Bulletin. 1978 Apr;27(4):795–8. doi: 10.1007/bf00925310. 参考文献:10.1007/bf00925309 摘要:Karpayichyus KI, Patotskene LA, Knunyants IL. Phenylalanine derivatives containing an acyl residue of the stereoisomeric N-[di(ethylenimino)(thio)phosphoryl]-4-aminocyclohexanecarboxylic acids. Russian Chemical Bulletin. 1978 Apr;27(4):790–5. doi: 10.1007/bf00925309.