CAS: 31282-04-9; (3As,3'R,4S,4'S,5'R,6R,6'R,7S,7As)-4-(((1R,2S,3R,5S,6R)-3-Amino-2,6-Dihydroxy-5-(Methylamino)Cyclohexyl)Oxy)-6'-((S)-1-Amino-2-Hydroxyethyl)-6-(Hydroxymethyl)Octahydro-3Ah-Spiro[[1,3]Dioxolo[4,5-C]Pyran-2,2'-Pyran]-3',4',5',7-Tetraol

专利信息

专利号:EP-1309698-B1
优先权日:2000-07-21
标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants
发明人：CAHOON EDGAR B
权利人:DU PONT
摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.

专利号:US-2025236876-A1
优先权日:2024-01-22
标题:Engineered yeast for efficient and rapid synthesis of erythritol and construction method thereof
发明人：CHENG HAIRONG; XU SHUO
权利人:UNIV SHANGHAI JIAOTONG
摘要:Disclosed are an engineered yeast for efficient and rapid synthesis of erythritol and a construction method thereof. Yarrowia lipolytica is used as a synthetic chassis for genetic improvement. A method for synthesizing erythritol is as follows: using glucose as a carbon source, and a nitrogen source and an inorganic salt as raw materials, sterilizing a medium, cooling the sterilized medium before inoculating yeast Yarrowia lipolytica , performing continuous fermentation or fed-batch fermentation under the condition of oxygen supply, and purifying erythritol from a fermentation broth. Under the condition of continuous feeding, the yield of erythritol is more than 350 g/L, and the production efficiency is more than 4.5 g/L·h, nearly 100% higher than that of a comparative strain.

专利号:EP-0303364-A1
优先权日:1987-08-10
标 题:Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from streptomyces clavuligerus
发明人：JENSEN SUSAN E; WESTLAKE DONALD W S; LESKIW BRENDA K; AHARONOWITZ YAIR DEP OF MIBROB; MEVARECH MOSHEIR DEP OF MIBROB
权利人:UNIV ALBERTA
摘要:The gene coding for the enzyme Isopenicillin N Synthetase (IPNS) isolated from the prokaryote Streptomyces clavuligerus is cloned and sequenced. The corresponding amino acid sequence is also determined. The enzyme IPNS controls the rate of synthesis of the β-­lactam family of antibiotics. The nucleotide sequence is incorporated into a vector to effect a transformation of a suitable host microorganism. Such a transformed microorganism is useful in making in vitro synthesis of the β-lactams more practical and in whole cell fermentations to produce higher levels of β-lactams.

专利号:US-2009197311-A1
优先权日:2006-06-20
标题:Method for the production of simvastatin
发明人：BERG MARCO ALEXANDER VAN DEN; HANS MARCUS; STREEKSTRA HUGO
权利人:BERG MARCO ALEXANDER VAN DEN; HANS MARCUS; STREEKSTRA HUGO
摘要:The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis; fermenting said host to obtain simvastatin or analogues or derivatives thereof, i.e. by producing simvastatin on an industrial scale by a fed-batch process.

专利号:US-11981938-B2
优先权日:2017-10-05
标 题 :Microorganisms and methods for the fermentation of cannabinoids
发明人：SZAMECZ BELA KRISZTIAN; VARSZEGI SZILVIA; NEMETH ATTILA; SZABO LORAND; KUMAR ABHINAV
权利人:ELESZTO GENETIKA INC
摘要:Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenic acid (CBCA), Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabichromene (CBC). Enzymes useful for the synthesis of CBGA and cannabinoids, include but are not limited to acyl activating enzyme (AAE1), polyketide synthase (PKS), olivetolic acid cyclase (OAC), prenyltransferase (PT), THCA synthase (THCAS), CBDA synthase (CBDAS), CBCA synthase (CBCAS), HMG-Co reductase (HMG1), and/or farnesyl pyrophosphate synthetase (ERG20). The microorganisms can also have one or more genes disrupted, such as gene that that controls beta oxidation of long chain fatty acids.

专利号:WO-9954471-A1
优先权日:1998-04-20
标 题:Polynucleotide sequences and their use in a method of producing plants with an increased number of stomata
发明人：VAN DER LEE FREDERIQUE MARIANN; SIJMONS PETER CHRISTIAAN; HETHERINGTON ALISTAIR MACULLOC; HOLROYD GEOFFREY HEYS; GRAY JULIE ELIZABETH
权利人:ZENECA LTD; LEE FREDERIQUE MARIANNE V D; SIJMONS PETER CHRISTIAAN; HETHERINGTON ALISTAIR MACULLOC; HOLROYD GEOFFREY HEYS; GRAY JULIE ELIZABETH
摘要:A method of producing plants with an increased number of stomata relative to control plants comprises the steps of: (i) inhibiting in plant material the production of fatty acids which stimulate the synthesis of the 14-3-3 class of transcription factors, or otherwise preventing the fatty acids from stimulating the synthesis of the said factors; (ii) selecting the thus inhibited material; and (iii) regenerating the thus selected material into plants. The inhibition may be achieved by sense co-suppression or anti-sense inhibition of an endogenous gene comprising a sequence which is complementary to one which when incubated at a temperature of between 60 and 65 °C in 0.3 strength citrate buffered saline containing 0.1 % SDS followed by rinsing at the same temperature with 0.3 strength citrate buffered saline containing 0.1 % SDS still hybridises with the sequence depicted in SEQ ID No.1. Preferred sequences for use in this method are depicted as SEQ ID No.1 and 2.